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Mutant KRAS vaccines for pancreatic cancer under clinical development – Bioscience Resources Consulting
https://biosci-rc.com/2016/12/15/mutant-kras-vaccines-for-pancreatic-cancer-under-clinical-development
Research and Development Analysis, Creating Value Based on Innovation. Mutant KRAS vaccines for pancreatic cancer under clinical development. Are developing vaccines that contain KRAS mutant peptides for patients with pancreatic cancer. These vaccines involve injection of the peptides and subsequent. GlobeImmune’s product is clinically more advanced with efficacy shown in a subset of pancreatic pancreatic cancer patients in a phase II clinical trial (see. KRAS vaccine combination strategies with agents t...
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Possible synergy between nimbolide and chloroquine as pancreatic cancer therapeutics? – Bioscience Resources Consulting
https://biosci-rc.com/2016/02/16/possible-synergy-between-nimbolide-and-chloroquine-as-pancreatic-cancer-therapeutics
Research and Development Analysis, Creating Value Based on Innovation. Possible synergy between nimbolide and chloroquine as pancreatic cancer therapeutics? Nimbolide is a phytochemical extracted from the leaves and flowers of the neem tree ( Azadirachta indica. Native to India. When applied to pancreatic cancer cell lines in vitro. Chloroquine has been shown to promote the cell death of KRAS activated cancers such as pancreatic cancer independently of autophagy (see here. King, M A, I G Ganley, and V Fl...
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Polyphenon E a promising Chinese/ green tea extract for cancer therapy – Bioscience Resources Consulting
https://biosci-rc.com/2016/02/10/polyphenon-e-a-promising-chinese-green-tea-extract-for-cancer-therapy
Research and Development Analysis, Creating Value Based on Innovation. Polyphenon E a promising Chinese/ green tea extract for cancer therapy. Polyphenon E represents a potential drug where clinical evidence of effect in many diseases has been found before the basic mechanism of action has been determined. Moving forward it will be very important to pinpoint the molecular targets of polyphenon E as these may be novel, provide new insight into disease biology, and ultimately provide a rationale for th...
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Mutant RAS vaccine showed trend for improved survival in a subset of pancreatic cancer patients – Bioscience Resources Consulting
https://biosci-rc.com/2016/03/21/mutant-ras-vaccine-showed-trend-for-improved-survival-in-a-subset-of-pancreatic-cancer-patients
Research and Development Analysis, Creating Value Based on Innovation. Mutant RAS vaccine showed trend for improved survival in a subset of pancreatic cancer patients. GlobeImmune’s $69M IPO Designed to Build Immunotherapy Pipeline – FierceBiotech’. Accessed 21 March 2016. http:/ www.fiercebiotech.com/story/globeimmunes-69m-ipo-designed-build-immunotherapy-pipeline/2012-07-03. 74, no. 19 Supplement (10 January 2014): 5314 5314. doi:10.1158/1538-7445.AM2014-5314. March 21, 2016. Pingback: Mutant KRAS vacc...
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Bladderwrack extract inhibits LDHA a potential drug target for pancreatic cancer – Bioscience Resources Consulting
https://biosci-rc.com/2016/02/18/bladderwrack-extract-inhibits-ldha-a-potential-drug-target-for-pancreatic-cancer
Research and Development Analysis, Creating Value Based on Innovation. Bladderwrack extract inhibits LDHA a potential drug target for pancreatic cancer. Bladderwrack ( fucus vesiculosus. Bladderwrack. Photo taken by Hans Kylberg. No changes were made. Creative Commons Attribution 2.0 Generic. Wikipedia, the Free Encyclopedia. 8 February 2016. https:/ en.wikipedia.org/w/index.php? 3, no 4 (2013): 603. http:/ www.ncbi.nlm.nih.gov/pmc/articles/PMC3903096/. Pan, Sheng, Ru Chen, Tyler Stevens, Mary P. Bro...
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Immune stimulation with PEGylated human IL-10 (AM0010) in patients with pancreatic and colorectal cancer – Bioscience Resources Consulting
https://biosci-rc.com/2017/01/05/immune-stimulation-with-pegylated-human-il-10-am0010-in-patients-with-pancreatic-and-colorectal-cancer
Research and Development Analysis, Creating Value Based on Innovation. Immune stimulation with PEGylated human IL-10 (AM0010) in patients with pancreatic and colorectal cancer. AM0010 is being developed by ARMO BioSciences. PEGylation of IL-10 allows for an extended half life in the body. It is important to note that the mechanism of action of AM0010 relies upon the presence of CD8 T cells within the tumor. Agents that promote the presence of of these cells are likely to be synergistic with AM0010. You a...
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Compound from Marine Sponge Reduces Pancreatic Tumor Size – Newsdesk | Florida Atlantic University – Bioscience Resources Consulting
https://biosci-rc.com/2016/08/25/compound-from-marine-sponge-reduces-pancreatic-tumor-size-newsdesk-florida-atlantic-university
Research and Development Analysis, Creating Value Based on Innovation. Compound from Marine Sponge Reduces Pancreatic Tumor Size – Newsdesk Florida Atlantic University. Lead author Esther Guzmán, Ph.D., associate research professor at FAU Harbor Branch, along with colleagues and co-authors Amy Wright, Ph.D., research professor; Tara Pitts, biological scientist; and Priscilla Winder, Ph.D., research associate; as well as collaborators from Eisai Pharmaceuticals. And the University of Central Florida.
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Chinese medicine flower, San Qi Hua, extract RN1 inhibited pancreatic cancer cell growth by targeting galectin-3 – Bioscience Resources Consulting
https://biosci-rc.com/2016/10/05/chinese-medicine-flower-san-qi-hua-extract-rn1-inhibited-pancreatic-cancer-cell-growth-by-targeting-galectin-3
Research and Development Analysis, Creating Value Based on Innovation. Chinese medicine flower, San Qi Hua, extract RN1 inhibited pancreatic cancer cell growth by targeting galectin-3. An arabinogalactan polysaccharide known as RN1 can be extracted from the flower (San Qi Hua) of the chinese medicine herb. 1] In Latin, the word panax means “cure-all”. According to Chinese medicine (Figure 1) it is warm in nature, with a sweet but slightly bitter taste. A concoction incorporating. 丁侃, 王培培, 张蕾 (2015). ...
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Phycocyanin extract from blue-green algae (cyanobacteria) induced autophagic cell death in pancreatic cancer cell lines – Bioscience Resources Consulting
https://biosci-rc.com/2016/10/13/phycocyanin-extract-from-blue-green-algae-cyanobacteria-induced-autophagic-cell-death-in-pancreatic-cancer-cell-lines
Research and Development Analysis, Creating Value Based on Innovation. Phycocyanin extract from blue-green algae (cyanobacteria) induced autophagic cell death in pancreatic cancer cell lines. Phycocyanin is a pigment-protein complex produced by certain cyanobacteria. It is composed of two protein subunits α-phycocyanin (18.4 kDa) and β-phycocyanin (21.3 kDa). As its name suggests phycocyanin in solution produces a blue-green colour (figure 1). Stable isolation of phycocyanin from. In other models phycocy...
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