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Welcome to the Membrane Protein Structural Biology Consortium. Structure of the integral membrane protein CaaX protease (Ste24p) from. Mutations in the human ortholog of Ste24p are linked to premature aging in children, and interactions of Ste24p with certain AIDS medications may lead to treatment side effects. MPSBC is one of 9 membrane protein structure determina- tion centers established in July 2010 as part of the NIGMS PSI:Biology Initiative. Supported by NIH/NIGMS Grant GM094611.

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Welcome to the Membrane Protein Structural Biology Consortium. Structure of the integral membrane protein CaaX protease (Ste24p) from. Mutations in the human ortholog of Ste24p are linked to premature aging in children, and interactions of Ste24p with certain AIDS medications may lead to treatment side effects. MPSBC is one of 9 membrane protein structure determina- tion centers established in July 2010 as part of the NIGMS PSI:Biology Initiative. Supported by NIH/NIGMS Grant GM094611.

<META> KEYWORDS

1 overview

2 hts services

3 laboratories

4 malkowski

5 dumont

6 wiener

7 people

8 investigators

9 staff directory

10 research

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overview,hts services,laboratories,malkowski,dumont,wiener,people,investigators,staff directory,research,pipeline,yeast tmp production,pre crystallization screening,ht crystallization screening,membrane protein crystallization,target,target summary

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index | mpsbc.org Reviews

https://mpsbc.org

Welcome to the Membrane Protein Structural Biology Consortium. Structure of the integral membrane protein CaaX protease (Ste24p) from. Mutations in the human ortholog of Ste24p are linked to premature aging in children, and interactions of Ste24p with certain AIDS medications may lead to treatment side effects. MPSBC is one of 9 membrane protein structure determina- tion centers established in July 2010 as part of the NIGMS PSI:Biology Initiative. Supported by NIH/NIGMS Grant GM094611.

INTERNAL PAGES

mpsbc.org

1

dumont

http://www.mpsbc.org/About/Laboratories/Dumont/dumont.html

Dr Mark Dumont’s laboratories are located in the Center for Pediatric Biomedical Research. In the MRBX building of the University of Rochester Medical Center, and they are affiliated with the Department of Pediatrics. Has extensive experience in the fields of yeast biology and biochemistry, and he has been involved in several genomic-scale projects to clone, express and purify proteins from. As well as from the yeast. He is now focusing on the development of technology for the use of.

2

mpsbc people

http://www.mpsbc.org/People/people/people.html

March 17, 2014. Front Row: Nadia Fedoriw, Michael Wiener, Da-Neng Wang (Advisor), Joe Gindhart (NIH),. Mike Malkowski, Guan Zhu, Daniel Councell, Mark Dumont,. Back Row: Deandra Irving, Kathy Clark, Mary Rosenblum, Bill Bauer, Nick Huang, Chuck Weeks.

3

target links

http://www.mpsbc.org/Targets/target_links.html

C-4 methyl sterol oxidase. Catalytic subunit of 1,3-beta-D-glucan synthase. Catalytic subunit of 1,3-beta-D-glucan synthase. IPC synthase regulatory subunit. Delta(9) fatty acid desaturase. Type II CAAX prenyl protease. Pheromone alpha factor receptor. Isoprenylcysteine carboxyl methyltransferase (ICMT). CAAX prenyl protease 1. V-type proton ATPase subunit a,. High-affinity K transport protein. Low-affinity K transport protein. Vacuolar membrane cation-chloride cotransporter.

4

mpsbc investigators

http://www.mpsbc.org/People/Investigators/investigators.html

Dr Mark E. Dumont. Mark Dumont@urmc.rochester.edu. Yeast TMP expression, solubilization, functional characterization, and purification. Dr Michael G. Malkowski. High-throughput membrane protein crystallization screens. Precrystallization screening for membrane protein stability in diverse detergents.

5

Caax Protease Ste24p

http://www.mpsbc.org/Results/Ste24p/Ste24p.html

STRUCTURE OF THE CaaX PROTEASE Ste24p. MPSBC investigators have determined the crystal structure of the CaaX protease Ste24p from. This structure was published in the March 29 (2013) issue of. Along with a perspectives commentary ( A protease for the ages. It was also the subject of an APS science highlight. Function of CaaX proteases. A human ortholog of Ste24p, ZMPSTE24 ( Z. Severity of different forms of progeria is reported to be correlated with the extent of loss of ZMPSTE24 activity. In additio...

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psimr.asu.edu

PSI:Biology-Materials Repository

http://psimr.asu.edu/MRLinks.html

PSI:Biology Material Repository Links. DNASU Twitter feed @DNASUPlasmids. For ordering PSI plasmids. For Next Generation and Sanger Sequencing. Virginia G. Piper Center for Personlized Diagnostics. The research center housing the PSI:Biology-Materials Repository. PSI Structural Biology Knowledgebase. Structural, Biological, Annotation, and Experimental data. NIH/NIGMS PSI:Biology Initiative Website. University of California - San Francisco. CSMP Biological Partner - University of Kansas. Integrated Cente...

mpid.asu.edu

MPID :: Links

http://mpid.asu.edu/page_links.php

Membrane Proteins in Infectious Diseases. Center for Membrane Proteins in Infectious Diseases (MPID). Protein Structure Initiative (PSI). Http:/ www.nigms.nih.gov/Initiatives/PSI/. PSI Structural Biology Knowledgebase (SBKB). Http:/ psimr.asu.edu. Http:/ dnasu.asu.edu. Midwest Center for Structural Genomics. Http:/ www.mcsg.anl.gov/. Joint Center for Structural Genomics. Http:/ www.jcsg.org/. Northeast Structural Genomics Consortium. Http:/ www.nesg.org/. New York Structural Genomics Research Consortium.

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mpsbc.org

index

Welcome to the Membrane Protein Structural Biology Consortium. Structure of the integral membrane protein CaaX protease (Ste24p) from. Mutations in the human ortholog of Ste24p are linked to premature aging in children, and interactions of Ste24p with certain AIDS medications may lead to treatment side effects. MPSBC is one of 9 membrane protein structure determina- tion centers established in July 2010 as part of the NIGMS PSI:Biology Initiative. Supported by NIH/NIGMS Grant GM094611.

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