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MRCP revision

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1

MRCP revision: January 2012

http://mrcpart1revision.blogspot.com/2012_01_01_archive.html

Sunday, 15 January 2012. Reduced activity of cystathionine B-synthase. Accumulation of homocysteine and methionine. Interfere with collagen cross-linking. Similar to Marfan's syndrome, but with downward lens dislocation, venous and arterial thrombosis, developmental and mental retardation. Premature cardiovascular risk increased in heterozygote. Cyanide-nitroprusside test showed elevated urinary homocysteine. Management: methionine restriction, cysteine and pyridoxine supplements. PKD 2 : chromosome 4.

2

MRCP revision: December 2011

http://mrcpart1revision.blogspot.com/2011_12_01_archive.html

Saturday, 31 December 2011. Polymyositis - reduced amplitude and duration of motor units. Motor neurone disease - fibrillation due to denervation. Myasthenia gravis - diminished response to repetitive stimulation. Lambert Eaton syndrome - enhanced response to repeated stimulation. Myotonia dystrophia - high frequency action potentials (Kamikazee discharge). Demyelinating neuropathy - slow nerve conduction velocity. Axonal neuropathy - diminished action potential. Lasts 15-160mins, often nocturnal. CSF: a...

3

MRCP revision: June 2012

http://mrcpart1revision.blogspot.com/2012_06_01_archive.html

Saturday, 30 June 2012. Characteristic concentric erythematous bands. Forming a wood-grain appearance. In up to 80% of patients. Most develop the eruption before the symptoms of malignancy. Rare multisystem disease that occurs in the setting of plasma cell dyscrasia. P - polyneuropathy (symmetrical and distal). O - organomegaly (liver, spleen and lymph nodes). M - monoclonal gammopathy. S - skin abnormalities (hyperpigmentation and hypertrichosis). Sunday, 24 June 2012. Saturday, 23 June 2012. Is an alte...

4

MRCP revision: July 2012

http://mrcpart1revision.blogspot.com/2012_07_01_archive.html

Sunday, 15 July 2012. Rapidly progressive glomerulonephritis (RPGN). Distinctive acute eruption of small, drop-like, 1-10mm in diameter, salmon-pink papules, usually with a fine scale. URTI from group A beta-hemolytic streptococci often precedes the eruption by 2-3 weeks. Primarily occurs on trunk and proximal extremities. Tuesday, 10 July 2012. Aka brachial neuritis, Parsonage-Turner syndrome, immune-mediated brachial plexus neuropathy (IBPN). Scapular winging in common. Monday, 9 July 2012. Other featu...

5

MRCP revision: Hereditary neuropathy

http://mrcpart1revision.blogspot.com/2012/07/hereditary-neuropathy.html

Thursday, 5 July 2012. Charcot Marie Tooth (CMT). Disease is the most common type of hereditary neuropathy. CMT type 1 (AD). Usually presents in the first to third decade of life with distal leg weakness (eg: footdrop). Muscle stretch reflexes are unobtainable or reduced throughout. Often atrophy of muscles below knee ( inverted champagne bottle leg. Nerve conduction is very reduced. CMT type 2 (AD). Tends to present later in life compared to type 1 and much milder. CMT type 3 / Dejerine Sottas (AR).

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Sunday, 15 July 2012. Rapidly progressive glomerulonephritis (RPGN). Distinctive acute eruption of small, drop-like, 1-10mm in diameter, salmon-pink papules, usually with a fine scale. URTI from group A beta-hemolytic streptococci often precedes the eruption by 2-3 weeks. Primarily occurs on trunk and proximal extremities. Tuesday, 10 July 2012. Aka brachial neuritis, Parsonage-Turner syndrome, immune-mediated brachial plexus neuropathy (IBPN). Scapular winging in common. Monday, 9 July 2012. Other featu...

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