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Lead Compounds
http://www.myelorx.com/Lead_Compounds.html
The Triptolide Company ™. The lead compound, MRx102 is being developed to treat AML under a Phase II SBIR contract from the National Cancer Institute. The compound is a lipophilic prodrug of triptolide, manufactured via a three-step synthesis from the natural product. . Through our relationship with Pharmagenesis. We have extensive experience in the cGMP manufacture of triptolide and its analogues. Table 1 - Cell Line (IC. 1 pre-incubation with human plasma 2. . Table 2- AML Xenograft Model (MV4-11).
Management
http://www.myelorx.com/Management.html
The Triptolide Company ™. John H. Musser, Ph.D., President. Dr Musser has over 30 years experience in the biotechnology and pharmaceutical industry focusing on the research and development of anticancer and immune modulatory drugs. He founded MyeloRx in 2007 when MyeloRx licensed the promising triptolide patent estate from Pharmagensis, Inc (PG). Prior to founding MyeloRx he was employed by PG where. Started his biotech career at Glycomed after working at Wyeth for 10 years. After receiving his B.A i...
Therapeutic Areas
http://www.myelorx.com/Therapeutic_Areas.html
The Triptolide Company ™. Triptolide-based drugs have shown clinical and/or pre-clinical activity in a variety of cancer types including leukemias and some solid tumors. The lead compound, MRx102. Is being developed initially for a number of leukemias including acute myeloid leukemia (AML), chronic myeloid leukemia, multiple myeloma and myelodysplastic syndrome, with AML being the first indication. There is an unmet medical need in AML particularly in elderly patients. MRx102 has shown activity in vitro ...
Home Page
http://www.myelorx.com/Home_Page.html
The Triptolide Company ™. MyeloRx, LLC is a privately held Northern California-based biotechnology company that develops drugs for oncology and immune-related diseases based on the natural product triptolide. Importantly, triptolide and the plant from which it is extracted, Tripterygium Wilfordii Hook f,. 160;analogs of the natural product. MyeloRx is a limited liability company registered in California. .
Patents & Publications
http://www.myelorx.com/Patents___Publications.html
The Triptolide Company ™. Through its contract with Pharmagenesis we have an exclusive license to five worldwide patent families covering prodrugs and derivatives of triptolide. We have also filed on novel formulations of our lead product, MRx102. Script embedded in HTML. Reno TA, Tong SW, Wu J, Fidler JM, Nelson R, Kim JY, Raz D. The triptolide derivative MRx102 inhibits Wnt pathway activation and has potent anti-tumor effects in lung cancer. BMC Cancer (2016) 16:439.
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The Triptolide Company ™. MyeloRx, LLC is a privately held Northern California-based biotechnology company that develops drugs for oncology and immune-related diseases based on the natural product triptolide. Importantly, triptolide and the plant from which it is extracted, Tripterygium Wilfordii Hook f,. 160;analogs of the natural product. MyeloRx is a limited liability company registered in California. .
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