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Blogs | Nanopore Group | nanopore.soe.ucsc.edu Reviews

https://nanopore.soe.ucsc.edu

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Nanopore Detectors | Nanopore Group

https://nanopore.soe.ucsc.edu/nanopore-detectors

Skip to main content. Protein nanopores can be constructed using a class of molecules, termed porins. We have previously used a nanoscale pore formed by the bacterial toxin, alpha-hemolysin(see below), and have recently been using a porin from. The organism uses the porin for importing nutrients from its environment, but when the porin is placed in a lipid bilayer, it becomes well suited as a nanopore with dimensions that are particularly useful for interpreting the sequence of a single strand of DNA.

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People | Nanopore Group

https://nanopore.soe.ucsc.edu/people

Skip to main content. We study the molecular mechanics of individual DNA polymerase complexes at the single molecule level, with sub-milllisecond and single nucleotide precision. We work in close collaboration with Dr. Hongyun Wang, Applied Mathematics and Statistics, UCSC. Direct observation of translocation in individual DNA polymerase complexes. Dahl JM, Mai AH, Cherf GM, Jetha NN, Garalde DR, Marziali A, Akeson M, Wang H, Lieberman KR. J Biol. Chem. J Am Chem. Soc. J Am Chem. Soc.

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About | Nanopore Group

https://nanopore.soe.ucsc.edu/about

Skip to main content. The Nanopore group is currently working on a number of projects including:. Basic science of nanopores and their implementation in biotechnology. Examining the molecular mechanics of individual DNA polymerase complexes at the single molecule level, with sub-milllisecond and single nucleotide precision. Identification, cloning and expression of new DNA polymerases for nanopore sequencing applications. Use of nanopores for detection of biosignatures in water samples.

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Patents | Nanopore Group

https://nanopore.soe.ucsc.edu/patents

Skip to main content. Compositions, devices, systems, for using a Nanopore. US Pat. App 12459059 - Filed Jun 26, 2009. Compositions, devices, systems, for using a Nanopore. US Pat. App 12450633 - Filed Apr 4, 2008. Characterization of individual polymer molecules based on monomer-interface. Interactions. US Pat. App 11717319 - Filed Mar 13, 2007. Methods and apparatus for characterizing polynucleotides. US Pat. App 11824949 - Filed Jul 3, 2007. This site is maintained by: makeson@soe.ucsc.edu.

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Publications | Nanopore Group

https://nanopore.soe.ucsc.edu/publications

Skip to main content. Dynamics of Translocation and Substrate Binding in Individual Complexes Formed with Active Site Mutants of Φ29 DNA Polymerase. Dahl JM, Wang H, Lazaro JM, Salas M, Lieberman KR. 2014 Jan 24. [Epub ahead of print]. Kinetic mechanism of translocation and dNTP binding in individual DNA polymerase complexes. Lieberman KR, Dahl JM, Mai AH, Cox A, Akeson M, Wang H. J Am Chem Soc. 2013 Jun 19;135(24):9149-55. doi: 10.1021/ja403640b. Epub 2013 Jun 7. J Am Chem Soc. Proc Natl Acad Sci U S A.

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Garaj Group | Nano/Bio Physics Laboratory

Welcome to Nano/Bio Physics Laboratory led by Dr. Slaven Garaj, at National University of Singapore. We investigate the behaviour of individual biomolecules in nanometre-scaled pores and channels. New nano-electrical devices; nano-sensors for detection of individual molecules. Development of new physical methods for inexpensive and fast DNA sequencing, using graphene nanopores. Read more about News.

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Blogs | Nanopore Group

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Welcome - Nanopore

Elucidating the transport mechanisms of molecules in biological and synthetic nanopores and -channels. Transport Mechanisms in Biological and Synthetic Nanopores and channels. The workshop will consist of invited lectures but also some contributed talks. We particularly invite junior scientists during their PhD or PostDoc to apply. The program will leave plenty of time for discussion, and all participants are encouraged to present their work in a poster session. Professor of Theoretical Physics (Focus Ar...

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NanoporeDx | Rapid, portable testing

Healthcare startups sweep podium at Startup Connection. Here are the 20 winners of this year’s Arch Grants. SAGE Labs to incubate Nanopore in Westport. Nanopore awarded Olin Cup, $50k investment. Nanopore Diagnostics is developing a rapid and portable platform for counting microbes right at the point-of-need. Enables detection without the long culture times required in other methods to increase the number of microbes in a sample before testing. Healthcare startups sweep podium at Startup Connection.

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