nephrogenex.com
Board of Directors - NephroGenex, Inc.
http://www.nephrogenex.com/about-us/board-directors
Innovative Therapies for Kidney Disease. Publications & Abstracts. PIONEER Phase 3 Program. Investors & Media. Publications & Abstracts. PIONEER Phase 3 Program. Investors & Media. Richard J. Markham. Richard J. Markham has been Chairman of the Board of Directors since October, and a member since 2007. Mr. Markham is also a partner at the venture capital firm Care Capital, LLC. Prior to joining Care Capital in 2004, he was the Vice Chairman of the Management Board and COO of Aventis. Mr Markham received ...
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What is Chronic Kidney Disease?
http://www.nephrogenex.com/kidney-disease
Innovative Therapies for Kidney Disease. Publications & Abstracts. PIONEER Phase 3 Program. Investors & Media. Publications & Abstracts. PIONEER Phase 3 Program. Investors & Media. Chronic Kidney Disease Affects Over One-Third of Diabetics in the U.S. Patients with long-standing diabetes are at high risk for developing renal failure. Hypertension, uncontrolled blood sugar may pose irreversible kidney damage. Some common, and even early, indications of CKD are:. Muscle cramping at night. Dry, itchy skin.
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Diabetic Nephropathy: A Chronic Complication of Diabetes
http://www.nephrogenex.com/kidney-disease/diabetic-nephropathy
Innovative Therapies for Kidney Disease. Publications & Abstracts. PIONEER Phase 3 Program. Investors & Media. Publications & Abstracts. PIONEER Phase 3 Program. Investors & Media. Diabetic Nephropathy: A Chronic, Life-Threatening Complication of Diabetes. Within the bloodstream, the excessively high glucose reacts with proteins to form unstable compounds known as Schiff bases which are rapidly converted to more stable compounds known as Amadori products. These Amadori products are in-turn converted ...
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Earlier clinical studies with Pyridorin
http://www.nephrogenex.com/clinical-trials/previous-pyridorin-clinical-studies
Innovative Therapies for Kidney Disease. Publications & Abstracts. PIONEER Phase 3 Program. Investors & Media. Publications & Abstracts. PIONEER Phase 3 Program. Investors & Media. PIONEER Phase 3 Program. Early Studies Show Clinical Benefit for Target Patient Population. Pyridorin well tolerated, with adverse event rates similar to placebo. Following several preclinical and Phase 1 studies, four placebo-controlled PYRIDORIN. PYR-206 was a Phase 2, multi-center, placebo-controlled, randomized, double-bli...
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What is Acute Kidney Injury?
http://www.nephrogenex.com/kidney-disease/acute-kidney-injury
Innovative Therapies for Kidney Disease. Publications & Abstracts. PIONEER Phase 3 Program. Investors & Media. Publications & Abstracts. PIONEER Phase 3 Program. Investors & Media. Many Critical Care Patients Are at Risk for Acute Kidney Injury. The condition can result in loss of kidney function in just 1-2 days. AKI is a serious condition that is estimated to affect between 7 and 18 percent of hospital inpatients. Major causes of acute kidney injury include:. The prognosis for AKI depends on the severi...
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Pyridorin: Treatment in development for diabetic nephropathy
http://www.nephrogenex.com/product-candidates/pyridorin
Innovative Therapies for Kidney Disease. Publications & Abstracts. PIONEER Phase 3 Program. Investors & Media. Publications & Abstracts. PIONEER Phase 3 Program. Investors & Media. Publications & Abstracts. Pyridorin: A Novel Acting Compound to Improve Treatment of Diabetic Nephropathy. Addressing an unmet medical need to slow disease progression. Currently available treatments for diabetic nephropathy are effective but a significant residual risk remains. Unlike any currently approved therapies, Pyridor...
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Pipeline - NephroGenex, Inc.
http://www.nephrogenex.com/clinical-trials/pipeline
Innovative Therapies for Kidney Disease. Publications & Abstracts. PIONEER Phase 3 Program. Investors & Media. Publications & Abstracts. PIONEER Phase 3 Program. Investors & Media. PIONEER Phase 3 Program. Publications & Abstracts. PIONEER Phase 3 Program. Investors & Media. Events & Presentations. Annual Reports & Proxies. PYRIDORIN (pyridoxamine dihydrochloride) is a registered trademark of NephroGenex, Inc.
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Publications & Abstracts - NephroGenex, Inc.
http://www.nephrogenex.com/product-candidates/publications-abstracts
Innovative Therapies for Kidney Disease. Publications & Abstracts. PIONEER Phase 3 Program. Investors & Media. Publications & Abstracts. PIONEER Phase 3 Program. Investors & Media. Publications & Abstracts. Publications & Abstracts. Clinical and Preclinical Activities of PYRIDORIN. Zheng F, Zeng YJ, Plati AR, Elliot SJ, Berho M, Potier M, Striker LJ, Striker GE. Combined AGE inhibition and ACEi decreases the progression of established diabetic nephropathy in B6 db/db mice. Kidney Int. 70:507-...Kakuta T,...
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Management Team - NephroGenex, Inc.
http://www.nephrogenex.com/about-us/management-team
Innovative Therapies for Kidney Disease. Publications & Abstracts. PIONEER Phase 3 Program. Investors & Media. Publications & Abstracts. PIONEER Phase 3 Program. Investors & Media. John P. Hamill. Chief Executive Officer and Chief Financial Officer. Publications & Abstracts. PIONEER Phase 3 Program. Investors & Media. Events & Presentations. Annual Reports & Proxies. PYRIDORIN (pyridoxamine dihydrochloride) is a registered trademark of NephroGenex, Inc.
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NephroGenex - Innovation in the treatment of Kidney Disease
http://www.nephrogenexinc.com/about-us
Innovative Therapies for Kidney Disease. Publications & Abstracts. PIONEER Phase 3 Program. Investors & Media. Publications & Abstracts. PIONEER Phase 3 Program. Investors & Media. NephroGenex is an innovator in the development of drugs to treat kidney disease, with a first indication in diabetic nephropathy. We have been pioneering the development of PYRIDORIN. We believe Pyridorin represents real hope for the millions of type 2 diabetic patients around the world who have diabetic nephropathy.
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