newtonlab.ucsd.edu

Alexandra Newton Lab - UC San Diego

Our lab investigates the molecular mechanisms of signal propagation and signal termination in the phospholipase C (PLC) and PI3 kinase (PI3-K) signaling pathways. We focus on how protein kinase C. Protein kinase B) are 1] activated by phosphorylation and second messengers, and 2] inactivated by dephosphorylation catalyzed by the new phosphatase PH. Eucine rich repeat P. Biomedical Sciences Graduate Program. 2011 Alexandra Newton Lab - UC San Diego.

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Alexandra Newton Lab - UC San Diego | newtonlab.ucsd.edu Reviews

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Our lab investigates the molecular mechanisms of signal propagation and signal termination in the phospholipase C (PLC) and PI3 kinase (PI3-K) signaling pathways. We focus on how protein kinase C. Protein kinase B) are 1] activated by phosphorylation and second messengers, and 2] inactivated by dephosphorylation catalyzed by the new phosphatase PH. Eucine rich repeat P. Biomedical Sciences Graduate Program. 2011 Alexandra Newton Lab - UC San Diego.

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1 alexandra newton lab

2 members

3 publications

4 protocols

5 pkc primer

6 videos

7 in the news

8 welcome

9 and akt

10 domain l

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Alexandra Newton Lab - UC San Diego | newtonlab.ucsd.edu Reviews

https://newtonlab.ucsd.edu

Our lab investigates the molecular mechanisms of signal propagation and signal termination in the phospholipase C (PLC) and PI3 kinase (PI3-K) signaling pathways. We focus on how protein kinase C. Protein kinase B) are 1] activated by phosphorylation and second messengers, and 2] inactivated by dephosphorylation catalyzed by the new phosphatase PH. Eucine rich repeat P. Biomedical Sciences Graduate Program. 2011 Alexandra Newton Lab - UC San Diego.

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newtonlab.ucsd.edu

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Videos - Alexandra Newton Lab - UC San Diego

http://newtonlab.ucsd.edu/videos.shtml

Alzstream™ Webinar: The Cancer and Alzheimer’s Connection:. Overturning a Cancer Dogma Corina Antal TEDxUHasselt. Activation Cycle of Protein Kinase C. Biomedical Sciences Graduate Program. 2011 Alexandra Newton Lab - UC San Diego.

2

Protocols - Alexandra Newton Lab - UC San Diego

http://newtonlab.ucsd.edu/protocols.shtml

Protein Kinase C Activity Assay. The following is a modification of Kikkawa et al., (1982) J. Biol. Chem. 257, 13341. This assay measures phosphorylation (. P) of a protein kinase C-peptide substrate, which is subsequently separated by binding to phosphocellulose paper. This assay system can be used to measure activity of the purified kinase, or the activity in crude cellular extracts. Protein kinase C sample can be diluted in 20 mM HEPES/ 2 mM DTT mmediately prior to assay. Stocks) are mixed in a glass ...

3

Alexandra Newton Lab - UC San Diego

http://newtonlab.ucsd.edu/news.shtml

Press releases for Alfonso et al. 2016. Gain-of-function mutations in protein kinase Cα (PKCα) may promote synaptic defects in Alzheimer’s disease. S ci Signal. 10 May 2016: Vol. 9, Issue 427, pp. ra47. Therapy that failed with cancer could fight Alzheimer's. Genetic Variations that Boost PKC Enzyme Contribute to Alzheimer’s Disease. PKCα in Alzheimer’s disease. For Alfonso et al. 2016. Gain-of-function mutations in protein kinase Cα (PKCα) may promote synaptic defects in Alzheimer’s disease. Identificat...

4

Publications - Alexandra Newton Lab - UC San Diego

http://newtonlab.ucsd.edu/publications.shtml

Reviews are in green. Protein kinase C mechanisms that contribute to cardiac remodelling. Newton AC, Antal CE, Steinberg SF. Clin Sci (Lond). 2016 Sep 1;130(17):1499-510. PDF. Newton AC, Bootman MD, and Scott JD. Cold Spring Harb Perspect Biol. 2016 Aug. PDF. Bacterial spore coat protein kinases: A new twist to an old story. Scott JD, Newton AC. Proc Natl Acad Sci U S A. 2016 Jun 21;113(25):6811-2. PDF. J Biol Chem. 2016 Jul 1;291(27):13964-73. PDF. S control localized protein kinase C ζ Activity. Intram...

5

Members - Alexandra Newton Lab - UC San Diego

http://newtonlab.ucsd.edu/members.shtml

Irene Tobias (Ph.D. 2016). Corina Antal (Ph.D. 2015). Alyssa Wu-Zhang (Ph.D. 2012). Audrey O'Neill (Ph.D. 2012). Noel Warfel (Ph.D. 2011). Matt Niederst (Ph.D. 2011). Lisa L. Gallegos (Ph.D. 2009). Lisa Gallegos@hms.harvard.edu. Christine Gould (Ph.D. 2009). John Brognard (Ph.D. 2007). Jbrognard@picr.man.ac.uk. Dan Dries (Ph.D. 2006). Angela Scott (Ph.D. 2006). Jaime Marach (Ph.D. 2006). Dan Chen (Ph.D. 2003). Jon Violin (Ph.D. 2003). Ryan Adams (Ph.D. 2002). Erica (Dutil) Sonnenburg (Ph.D. 2000).

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University of California, San Diego. Department of Chemistry and Biochemistry. UCSD School of Medicine. San Diego Supercomputer Center. Ruben Abagyan, TSRI. Jack Dixon, UCSD. Gouri Ghosh Lab, UCSD. Elizabeth Komives, UCSD. Alexandra Newton, UCSD. Roger Tsien, UCSD, HHMI. Photo by Grant Hochstein. Leichtag Biomedical Research Building 4th Floor, Room 412. University of California, San Diego. 9500 Gilman Dr. mc0654. La Jolla, CA 92093.

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Alexandra Newton Lab - UC San Diego

Our lab investigates the molecular mechanisms of signal propagation and signal termination in the phospholipase C (PLC) and PI3 kinase (PI3-K) signaling pathways. We focus on how protein kinase C. Protein kinase B) are 1] activated by phosphorylation and second messengers, and 2] inactivated by dephosphorylation catalyzed by the new phosphatase PH. Eucine rich repeat P. Biomedical Sciences Graduate Program. 2011 Alexandra Newton Lab - UC San Diego.

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