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HOMEWe seek to understand the molecular basis, evolutionary history, and medical relevance of invertebrate allorecognition. To do this, we use the colonial hydroid Hydractinia symbiolongcarpus as a...
http://www.nicotralab.org/
We seek to understand the molecular basis, evolutionary history, and medical relevance of invertebrate allorecognition. To do this, we use the colonial hydroid Hydractinia symbiolongcarpus as a...
http://www.nicotralab.org/
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https://nicotralab.org
We seek to understand the molecular basis, evolutionary history, and medical relevance of invertebrate allorecognition. To do this, we use the colonial hydroid Hydractinia symbiolongcarpus as a...
nicotralab.org
OUTREACH - The Nicotra Lab
http://www.nicotralab.org/outreach.html
Pitt Mobile Science Lab. In collaboration with the staff of the Pitt Mobile Science Lab. We are developing an educational module to teach high school students basic molecular biology techniques in the context of. Allorecognition. Students will use PCR and gel electrophoresis to predict the genotypes of hydractinia colonies, and then test their predictions by observing those same colonies interact in real time. This module will be incorporated into the curriculum of the Mobile Science Lab, a self-...This ...
PUBLICATIONS - The Nicotra Lab
http://www.nicotralab.org/publications.html
Karadge UB, Gosto M, and Nicotra ML. Allorecognition mediated by homophilic protein-protein interactions in an invertebrate". Houser BL, Tilburgs T, Hill J, Nicotra ML. Strominger JL. 2011. “Two unique human decidual macrophage populations.”. Rosengarten RD and Nicotra ML. 2010 "Model systems of invertebrate allorecognition.". Rosa SFP, Powell AE, Rosengarten RD,. Moreno MA, Grimwood J, Lakkis FG, Dellaporta SL, Buss LW. 2010. “. Resides in an Immunoglobulin Superfamily-like gene complex.”. THOMAS E....
Current Projects - The Nicotra Lab
http://www.nicotralab.org/current-projects.html
The biophysical and structural basis of allorecognition specificity. How do alr1 and alr2, by themselves, distinguish self from non-self? The allorecognition signaling pathway. To answer this question, one must first define the allorecognition signal transduction pathway. We hypothesize that the cytoplasmic tails of alr1 and alr2 initiate allorecognition responses because they are relatively large and bear a number of potential phosphorylation sites. Our current work focuses on determining whethe...Predi...
What is Hydractinia? - The Nicotra Lab
http://www.nicotralab.org/what-is-hydractinia.html
We study allorecognition in. The Allorecognition Complex (ARC). Using inbred lines of. We and our collaborators have demonstrated that allorecognition is controlled by two linked genes, called. Alleles in a single population! And sequence variation in the extracellular domain predicts allorecognition phenotypes. No unlinked allorecognition loci have been detected in systematic searches of three wild-type genetic backgrounds. Schematic of a Hydractinia. Rejection between two Hydractinia.
Allorecognition & Transplantation - The Nicotra Lab
http://www.nicotralab.org/allorecognition--transplantation.html
If invertebrate allorecognition systems are homologous to elements of mammalian immune systems, it could lead to the identification of new or previously unappreciated signaling pathways involved in the graft rejection. Our ongoing work to define the allorecognition signaling pathway in. Is generating data to address exactly this issue. As members of the Thomas E. Starzl Transplantation Institute. At the University of Pittsburgh. We are uniquely positioned to translate findings from.
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Welcome to the Nicotra Lab! We seek to understand the molecular basis, evolutionary history, and medical relevance of invertebrate allorecognition. To do this, we use the colonial hydroid. As a model system. 65279;2017-06-30 - Aidan Huene passes her comps! 2016-02-12 - Aidan Huene joins the lab. THOMAS E. STARZL TRANSPLANTATION INSTITUTE. 2017 Matthew Nicotra Updated March 23, 2018. This site was created and is maintained through support from the National Science Foundation.
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