Overview Our Challenge 17 million people worldwide suffer a stroke every year – only 10% will ever return to life as it was before. NoNO has a single-minded focus on protecting against the damaging effects of stroke during the emergency phase and to enhance the recovery once a stroke has already occurred. Our Pipeline We have long believed in
http://www.nonoinc.ca/
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nonoinc.ca | nonoinc.ca Reviews
https://nonoinc.ca
Overview Our Challenge 17 million people worldwide suffer a stroke every year – only 10% will ever return to life as it was before. NoNO has a single-minded focus on protecting against the damaging effects of stroke during the emergency phase and to enhance the recovery once a stroke has already occurred. Our Pipeline We have long believed in
nonoinc.ca
Publications
http://nonoinc.ca/page8/index.html
Sattler R, Xiong Z, Lu WY, et al: Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein. Aarts M, Liu Y, Liu L, et al: Treatment of ischemic brain damage by perturbing NMDA receptor- PSD-95 protein interactions. Cui H, Hayashi A, Sun H, et al: PDZ Protein Interactions Underlying NMDA-Receptor-Mediated Excitotoxicity and Neuroprotection by PSD-95 Inhibitors. 28 (42):10696-10710, 2008. 2012 NoNO Inc. Contact Us.
Board of Directors
http://nonoinc.ca/page3/page4/index.html
Michael Tymianski, MD, PhD, FRCSC. Michael W. Salter, MD, PhD. Josh Josephson, OD, FAAO, FBCLA. 2012 NoNO Inc. Contact Us.
Pipeline Programs
http://nonoinc.ca/page0/index.html
NMDA glutamate receptors mediate pain hypersensitivity in the nervous system. NMDA receptor activity is enhanced by Src kinase, which interacts with the NMDA receptor through the adaptor protein ND2. Disrupting the interactions of Src and ND2 is a novel strategy demonstrated to reduce inflammatory and neuropathic pain behaviours in animals. NoNO has developed inhibitors of these interactions with high potency and a large therapeutic index. 2012 NoNO Inc. Contact Us.
NA-1 Therapeutic Program
http://nonoinc.ca/page2/page2.html
Overview: Acute Neurological Disorders. Development of a safe and effective treatment for acute neurological disorders, especially those related to ischemia in the brain, remains one of the preeminent challenges in all of biomedical sciences. Acute Ischemic Stroke (AIS), Subarachnoid Hemorrhage (SAH) and Procedurally Induced Strokes (PIS) affect millions of people each year. NA-1 for Acute Neurological Disorders. 2012 NoNO Inc. Contact Us.
Company Info
http://nonoinc.ca/index.html
NoNO Inc. is a private, clinical-stage biotherapeutics company dedicated to the research, development and commercialization of pharmaceuticals for the treatment of common health disorders with unmet needs, including stroke, traumatic brain injury, and pain. NoNO is headquartered in Toronto, Canada. 2012 NoNO Inc. Contact Us.
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