oncopathology.info
Oncopathology: March 2010
http://www.oncopathology.info/2010_03_01_archive.html
High Grade Prostatic Intraepithelial Neoplasia (HGPIN). High Grade Prostatic Intraepithelial Neoplasia (HGPIN):. Common questions asked about HGPIN are :. How do we as pathologists make these diagnoses? What do they mean for the patient in terms of cancer risk? What is/are the optimal strategies for follow-up so that if cancer does eventually develop it is caught at an early, curable stage? Pathology criteria for diagnosis of HGPIN:. Architecturally benign acini/ducts lined by atypical cells. Follow up s...
oncopathology.info
Oncopathology: March 2014
http://www.oncopathology.info/2014_03_01_archive.html
How Do You Get Pancreatic Cancer? DrPrashant A.Jani M.D.FRCPC. Invasive Micropapillary Carcinoma of the Breast. Breast carcinoma with a prominent (pseudo) micropapillary pattern. Numerous small pseudo-papillary clusters of cells. Frequent central lumen formation in clusters. Peripherally located nuclei frequently bulge out with knobby appearance, "the hedgehog" tumor. Clusters surrounded by clear spaces. One or only a few clusters per space. Scant mucin rarely detectable in spaces. Moderate varibility in...
oncopathology.info
Oncopathology: June 2013
http://www.oncopathology.info/2013_06_01_archive.html
Paget's disease if Nipple- Review. Approximately 1%–3% of women with adenocarcinoma of the breast have Paget disease. Clinically-Paget disease has common dermatitis-like appearance, as originally described in 1874, when Sir James Paget recorded that such lesions may resemble “ordinary chronic eczema” or present as nipple erosion or ulceration. Paget disease often has a deceptively banal clinical morphology but should lead the list of differential diagnoses when evaluating unilat...In addition, because of...
oncopathology.info
Oncopathology: September 2009
http://www.oncopathology.info/2009_09_01_archive.html
Dysplasia in Inflammatory Bowel Disease. As we all know, chronic inflammatory bowel disease (IBD) presents a risk for dysplasia and subsequent malignancy in patients with long standing disease. The risk for adenocarcinoma increases with a number of factors including. The linear extent of disease within the bowel,. Early age at onset of disease,. Severity of disease and duration of disease. 1 Negative for dysplasia. 2 Indefinite for dysplasia. 3 Positive for dysplasia. This variability is one reason that ...
oncopathology.info
Oncopathology: August 2011
http://www.oncopathology.info/2011_08_01_archive.html
Mimics of Prostate Cancer –. Looks suspicious for adenocarcinoma at first glance. The nuclei are small and hyperchromatic. No prominent nucleoli are seen. Some glands are lined by obviously benign flattened atrophic epithelium. The immunostain for high molecular weight cytokeratin can be helpful in distinguishing between atrophy (fragmented basal cell layer) from atrophic variant of prostatic adenocarcinoma (no basal cell layer). It may show the infiltrative architecture of cancer,. The small hyperchroma...
oncopathology.info
Oncopathology: April 2012
http://www.oncopathology.info/2012_04_01_archive.html
Immunohistochemistry in the differential diagnosis of. Clear cell carcinomas from the kidney, liver, and lung. The most common primary sites that we see are kidney, lung, and liver (clear cell hepatoma). Low molecular weight cytokeratin. High molecular weight cytokeratin (clone 34. Because of its specificity for lung tumors,. Forward to a friend. DrPrashant A.Jani M.D.FRCPC. Subscribe to: Posts (Atom). List of all the posts. ASAP in prostate needle biopsy. Breast Carcinoma vs. Pulmonary Adenocarcinoma.
oncopathology.info
Oncopathology: Scientists Convert Human Skin Cells Directly Into Brain Cells
http://www.oncopathology.info/2015/04/scientists-convert-human-skin-cells.html
Scientists Convert Human Skin Cells Directly Into Brain Cells. Using a finely tuned cocktail of small molecules, researchers from Washington University in St. Louis. Is an inherited brain disorder that causes the progressive degeneration of nerve cells, or neurons. This disease predominantly affects a type of cell called medium spiny neurons (MSNs), which are crucial for movement control. As they are gradually lost in the brain, the patient experiences involuntary muscle movements. To human MSNs. Fur...
oncopathology.info
Oncopathology: July 2009
http://www.oncopathology.info/2009_07_01_archive.html
Immunopheotype of Gastrointestinal stromal tumours (GIST). It has been suggested that GISTs originate from the interstitial cell of Cajal (ICC), or from a primitive stem cell that differentiates towards both the ICC and smooth muscle phenotye. GISTs occur at every level of the GI tract. Most tumours arise in the stomach (60%) and about. Given the potential clinical importance of CD117 immunostaining, optimization of the staining techniques and reproducibility are critical. The pattern of staining is vari...
oncopathology.info
Oncopathology: November 2009
http://www.oncopathology.info/2009_11_01_archive.html
Desmoplastic melanoma, a common missed diagnosis. Although desmoplastic melanoma represents less than 2 percent of all melanomas, it's frequently misdiagnosed, due to a lack of distinctive clinical presentation features. Histologic diagnosis is rarely straightforward either. Patients are often middle age-to-elderly and present with the tumor most often on the head and neck region. The lesion may resemble a scar as it is often a hard nodule or plaque. Reporting of the histologic subtype of melanoma is com...
oncopathology.info
Oncopathology: How Do You Get Pancreatic Cancer?
http://www.oncopathology.info/2014/03/how-do-you-get-pancreatic-cancer.html
How Do You Get Pancreatic Cancer? DrPrashant A.Jani M.D.FRCPC. Subscribe to: Post Comments (Atom). List of all the posts. ASAP in prostate needle biopsy. Breast Carcinoma vs. Pulmonary Adenocarcinoma. Dysplasia in Inflammatory Bowel Disease. Errors in Surgical Pathology. False positive diagnosis in breast FNAC. Guidelines for Radical Prostatectomy Surgical Specimen Handling. High Grade Prostatic Intraepithelial Neoplasia (HGPIN). Immunohistochemistry in Follicular lymphoid lesions. Measuring size of DCIS.
