openflask.blogspot.com

Open Flask

Tuesday, August 11, 2015. We used C-H activation to make a natural product! Once upon a time, we were interested making fumitremorgin A. Phil's interest in verruculogen and fumitremorgin A has been long standing (see: Austamine. But strangely the endoperoxide-containing indole alkaloids haven't seen any attention despite the long history of syntheses of related natural products, including the (spiro)trypostatins, brevianamides, and other tryptophan-proline- diketopiperaizne. I don't even remember). That ...

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Open Flask | openflask.blogspot.com Reviews

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Tuesday, August 11, 2015. We used C-H activation to make a natural product! Once upon a time, we were interested making fumitremorgin A. Phil's interest in verruculogen and fumitremorgin A has been long standing (see: Austamine. But strangely the endoperoxide-containing indole alkaloids haven't seen any attention despite the long history of syntheses of related natural products, including the (spiro)trypostatins, brevianamides, and other tryptophan-proline- diketopiperaizne. I don't even remember). That ...

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Open Flask | openflask.blogspot.com Reviews

https://openflask.blogspot.com

Tuesday, August 11, 2015. We used C-H activation to make a natural product! Once upon a time, we were interested making fumitremorgin A. Phil's interest in verruculogen and fumitremorgin A has been long standing (see: Austamine. But strangely the endoperoxide-containing indole alkaloids haven't seen any attention despite the long history of syntheses of related natural products, including the (spiro)trypostatins, brevianamides, and other tryptophan-proline- diketopiperaizne. I don't even remember). That ...

INTERNAL PAGES

openflask.blogspot.com

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Open Flask: August 2015

http://www.openflask.blogspot.com/2015_08_01_archive.html

Tuesday, August 11, 2015. We used C-H activation to make a natural product! Once upon a time, we were interested making fumitremorgin A. Phil's interest in verruculogen and fumitremorgin A has been long standing (see: Austamine. But strangely the endoperoxide-containing indole alkaloids haven't seen any attention despite the long history of syntheses of related natural products, including the (spiro)trypostatins, brevianamides, and other tryptophan-proline- diketopiperaizne. I don't even remember). That ...

2

Open Flask: November 2013

http://www.openflask.blogspot.com/2013_11_01_archive.html

Wednesday, November 27, 2013. A selection of interesting "reactions" from around the lab. Happy Hanukkah and Thanksgiving Eve to all, here in the Baran lab, we have a lot. Of pretty mundane reactions running on a day to day basis, but sometimes things get weird. Heres a few of my observations that Ive managed to photodocument. As for the details of these reactions - Ill let those that ran them chime in if they care to. . Click through to see some photos. Thursday, November 21, 2013. When you place your m...

3

Open Flask: A Baran lab cycle of discovery: hydromethylation of unactivated olefins

http://www.openflask.blogspot.com/2015/06/a-baran-lab-cycle-of-discovery.html

Friday, June 19, 2015. A Baran lab cycle of discovery: hydromethylation of unactivated olefins. If the Baran lab cycle of discovery. In my last project. I barely made it to the first base with the synthesis of some steroid skeletons. When I was about to continue “the cycle” with some ideas for a further development, Phil told me not to, and convinced me to start a seemingly non-related project, a method for an overall addition of a methane molecule to unactivated olefins. How did we start? Thinking about...

4

Open Flask: February 2014

http://www.openflask.blogspot.com/2014_02_01_archive.html

Wednesday, February 19, 2014. Believe Everything You Read on the Internet. Sometimes, rumors pop up on the internet. You should always believe them. Seriously. Nobody on the internet lies. Just the other day, I read that Phil Baran is not actually from New Jersey, but he is in fact part of an advanced alien invasion from Mars. Seriously. I read it on the internet. It must be true. Friday, February 14, 2014. Structural Reassignment by Cool Science. Today, Vinogradova, Muller, and Buchwald. Searching the c...

5

Open Flask: The Recipe!

http://www.openflask.blogspot.com/2014/11/the-recipe.html

Wednesday, November 12, 2014. 8220;What’s cooking? 8221; was the question that Phil had asked me whenever he wanted to start a conversation back when I was a second-year student. Apparently, at that time, he was into “what’s cooking in chemistry.”. In this post, I would like to talk about how did we come up with the idea of using quinone diazides in "our recipe" (a recent ACIE. Publication,) but firstly…what is a quinone diazide? It is a "handsome" diazo compound! Personally, at first I wasn’t real...

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michaelhparker.wordpress.com

First world war dysentery bug was penicillin-resistant | Chemistry and Life

https://michaelhparker.wordpress.com/2014/11/08/first-world-war-dysentery-bug-was-penicillin-resistant-health-07-november-2014-new-scientist

Medicinal chemistry. Pharmacology. Toxicology. Environmental sciences. First world war dysentery bug was penicillin-resistant. November 8, 2014. By Michael H. Parker. Here’s an interesting story about drug resistant bacteria from before the first antibacterial agents were discovered:. First world war dysentery bug was penicillin-resistant – New Scientist. One thought on “ First world war dysentery bug was penicillin-resistant. Aww Black And White Couple Cute Dog Image 412081 On Favim Com. Next Post →.

michaelhparker.wordpress.com

About | Chemistry and Life

https://michaelhparker.wordpress.com/about

Medicinal chemistry. Pharmacology. Toxicology. Environmental sciences. Michael H. Parker is a PhD research chemist with an interest in the ways that chemical compounds interact with biological systems – medicinal chemistry, pharmacology, toxicology, and environmental sciences. 2 thoughts on “ About. February 19, 2017 at 3:19 am. Are there any natural medications or substances that are successful in helping people with depression? Michael H. Parker. February 20, 2017 at 1:38 am. Leave a Reply Cancel reply.

michaelhparker.wordpress.com

Michael H. Parker | Chemistry and Life

https://michaelhparker.wordpress.com/author/michaelhparker

Medicinal chemistry. Pharmacology. Toxicology. Environmental sciences. Author Archives: Michael H. Parker. November 23, 2015. By Michael H. Parker. If your dietary supplement is advertised to work as well as a pharmaceutical, it may be adulterated with one. That failed clinical trials or were dropped from development for various reasons (maybe toxicity, unacceptable side effects, etc) or never even advanced into clinical trials. Examples include acetildenafil, aildenafil, and thiosildenafil. Unsc...Color...

graphiteworks.wordpress.com

Finding Teaching Skills in Unexpected Places | Cheersical Education

https://graphiteworks.wordpress.com/2015/06/03/finding-teaching-skills-in-unexpected-places

All things chemical education: research, practice, theory, and more. New Vistas in Reaction Kinetics. Finding Teaching Skills in Unexpected Places. Developing Concepts in General Chemistry; Symposium on Chemistry MOOCs. Organic Chemistry Curriculum: A Step in the Right Direction. What Does “Inquiry” Mean? Adventures in the Midwest. Techniques in Learning and Teaching. June 3, 2015. Finding Teaching Skills in Unexpected Places. The other day as I was recording a video. No planes of symmetry at all. Brute ...

michaelhparker.wordpress.com

Periodic Table Battleship | Chemistry and Life

https://michaelhparker.wordpress.com/2015/06/24/periodic-table-battleship

Medicinal chemistry. Pharmacology. Toxicology. Environmental sciences. June 24, 2015. By Michael H. Parker. This is a cute idea for kids:. Leave a Reply Cancel reply. Enter your comment here. Fill in your details below or click an icon to log in:. Email (Address never made public). You are commenting using your WordPress.com account. ( Log Out. You are commenting using your Twitter account. ( Log Out. You are commenting using your Facebook account. ( Log Out. Notify me of new comments via email.

michaelhparker.wordpress.com

Can an old hallucinogen be a new antidepressant? | Chemistry and Life

https://michaelhparker.wordpress.com/2015/01/07/can-an-old-hallucinogen-be-a-new-antidepressant

Medicinal chemistry. Pharmacology. Toxicology. Environmental sciences. Can an old hallucinogen be a new antidepressant? January 7, 2015. By Michael H. Parker. Ketamine is an anesthetic and sedative drug developed in the 1960s. It’s not widely used anymore, primarily because there are better options. Among its side effects are dissociative and hallucinogenic effects. Because of these effects, ketamine has also been used as recreational drug with the street name “Special K”. Leave a Reply Cancel reply.

michaelhparker.wordpress.com

If your dietary supplement is advertised to work as well as a pharmaceutical, it may be adulterated with one | Chemistry and Life

https://michaelhparker.wordpress.com/2015/11/23/if-your-dietary-supplement-is-advertised-to-work-as-well-as-a-pharmaceutical-it-may-be-adulterated-with-one

Medicinal chemistry. Pharmacology. Toxicology. Environmental sciences. If your dietary supplement is advertised to work as well as a pharmaceutical, it may be adulterated with one. November 23, 2015. By Michael H. Parker. That failed clinical trials or were dropped from development for various reasons (maybe toxicity, unacceptable side effects, etc) or never even advanced into clinical trials. Examples include acetildenafil, aildenafil, and thiosildenafil. Unscrupulous supplement manufacturers ha...Http:...

modernsteroid.blogspot.com

modern steroid science: Glycosylation Reactions Involving a High Degree of Chemical Complexity: Nicolaou’s Total Synthesis of Shishijimicin A

http://modernsteroid.blogspot.com/2015/08/glycosylation-reactions-involving-high.html

Driven by the great medicinal potential of the steroidal sex hormones and anti-inflammatory agents, the period of the 1930s through the 1950s has been called the golden age of steroid chemistry. In recent years, steroid research has witnessed a renaissance, as a new generation of scientists has begun to recognize the pharmacologically privileged nature of the steroidal molecular framework. This blog highlights achievements pertaining to steroid technologies published from 2010 to the present. A number of...

modernsteroid.blogspot.com

modern steroid science: April 2015

http://modernsteroid.blogspot.com/2015_04_01_archive.html

Driven by the great medicinal potential of the steroidal sex hormones and anti-inflammatory agents, the period of the 1930s through the 1950s has been called the golden age of steroid chemistry. In recent years, steroid research has witnessed a renaissance, as a new generation of scientists has begun to recognize the pharmacologically privileged nature of the steroidal molecular framework. This blog highlights achievements pertaining to steroid technologies published from 2010 to the present. The authors...

heterocyclist.com

Uncategorized | The Heterocyclist

https://heterocyclist.com/category/uncategorized

A blog about heterocyclic chemistry. RSS for this section. April 29, 2013. Pd(II)-Catalyzed Dehydrogenative Cyclizations of. Near-simultaneous reports of an interesting new pyrrole (and dihydropyrrole) synthesis have appeared recently from the labs of Frank Glorius (Westfälische Wilhelms-Universität Münster). And Naohiko Yoshikai (Nanyang Technologial University, Singapore). The scope of the reaction is decent, as indicated below. Failures include R. Or cyclopropyl and R. February 4, 2013. I keep it upda...

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openflask.blogspot.com

Open Flask

Tuesday, August 11, 2015. We used C-H activation to make a natural product! Once upon a time, we were interested making fumitremorgin A. Phil's interest in verruculogen and fumitremorgin A has been long standing (see: Austamine. But strangely the endoperoxide-containing indole alkaloids haven't seen any attention despite the long history of syntheses of related natural products, including the (spiro)trypostatins, brevianamides, and other tryptophan-proline- diketopiperaizne. I don't even remember). That ...

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