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Inhibitor Selectivity for Cyclin-Dependent Kinase 7: A Structural, Thermodynamic, and Modelling Study. Kroll, S.H., Bondke, A., Barbazanges, M., Patel, H., Fuchter, M.J., Coombes, R.C., Ali, S., Barrett, A.G., Freemont, P.S. ChemMedChem. 2017, 12, 372. A novel pyrazolo[1,5-a]pyrimidine is a potent inhibitor of cyclin-dependent protein kinases 1, 2, and 9, which demonstrates antitumor effects in human tumor xenografts following oral administration. Heathcote DA, Patel H, Kroll SH, Hazel P. 2010, 53, 8508.

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Inhibitor Selectivity for Cyclin-Dependent Kinase 7: A Structural, Thermodynamic, and Modelling Study. Kroll, S.H., Bondke, A., Barbazanges, M., Patel, H., Fuchter, M.J., Coombes, R.C., Ali, S., Barrett, A.G., Freemont, P.S. ChemMedChem. 2017, 12, 372. A novel pyrazolo[1,5-a]pyrimidine is a potent inhibitor of cyclin-dependent protein kinases 1, 2, and 9, which demonstrates antitumor effects in human tumor xenografts following oral administration. Heathcote DA, Patel H, Kroll SH, Hazel P. 2010, 53, 8508.
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Dr. Pascale Hazel | pascalehazel.org Reviews

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Inhibitor Selectivity for Cyclin-Dependent Kinase 7: A Structural, Thermodynamic, and Modelling Study. Kroll, S.H., Bondke, A., Barbazanges, M., Patel, H., Fuchter, M.J., Coombes, R.C., Ali, S., Barrett, A.G., Freemont, P.S. ChemMedChem. 2017, 12, 372. A novel pyrazolo[1,5-a]pyrimidine is a potent inhibitor of cyclin-dependent protein kinases 1, 2, and 9, which demonstrates antitumor effects in human tumor xenografts following oral administration. Heathcote DA, Patel H, Kroll SH, Hazel P. 2010, 53, 8508.

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Pascale Hazel

http://www.pascalehazel.org/work.html

Post-Doctoral Research Associate, Imperial College, London. I'm working as part of the Cancer Drug Design and Development Group. Using X-ray crystallography to look at inhibitor binding to various cancer targets. I focus mainly on cyclin-dependent kinases, in particular CDK7 and CDK2. We have developed specific CDK7 inhibitors, and I'm using structural and biophysical methods in order to understand the origin of the specificity, and thus inform further inhibitor design. February 2006 - November 2009.

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Pascale Hazel

http://www.pascalehazel.org/index.html

For my travel photos, see my flickr stream.

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Pascale Hazel

http://www.pascalehazel.org/structures.html

CDK2 in complex with BS-194. BS-194, a highly specific inhibitor of CDK2. The crystal structure revealed a series of water-mediated interactions between the inhibitor and CDK2. G4T3G4 dimeric quadruplex structure.

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Inhibitor Selectivity for Cyclin-Dependent Kinase 7: A Structural, Thermodynamic, and Modelling Study. Kroll, S.H., Bondke, A., Barbazanges, M., Patel, H., Fuchter, M.J., Coombes, R.C., Ali, S., Barrett, A.G., Freemont, P.S. ChemMedChem. 2017, 12, 372. A novel pyrazolo[1,5-a]pyrimidine is a potent inhibitor of cyclin-dependent protein kinases 1, 2, and 9, which demonstrates antitumor effects in human tumor xenografts following oral administration. Heathcote DA, Patel H, Kroll SH, Hazel P. 2010, 53, 8508.

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