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Pathogenomics of Innate Immunity (PI2): A Genome Canada Project

The Pathogenomics of Innate Immunity, or PI2, project is a Genome Canada-funded project studying the mammalian innate immune system - the body's first line of defense against a range of bacteria, viral and other pathogens. Through the use of microarrays, mouse embryonic stem cell knockouts, siRNA, and bioinformatics, the project's aim is to understand key pathways and decision points in this important biological process.

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Pathogenomics of Innate Immunity (PI2): A Genome Canada Project | pathogenomics.ca Reviews
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The Pathogenomics of Innate Immunity, or PI2, project is a Genome Canada-funded project studying the mammalian innate immune system - the body's first line of defense against a range of bacteria, viral and other pathogens. Through the use of microarrays, mouse embryonic stem cell knockouts, siRNA, and bioinformatics, the project's aim is to understand key pathways and decision points in this important biological process.
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1 innate immunity
2 pathogenomics
3 pi2
4 genome canada
5 genome bc
6 genome prairie
7 genomics
8 pathogens
9 microarrays
10 stem cells
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Pathogenomics of Innate Immunity (PI2): A Genome Canada Project | pathogenomics.ca Reviews

https://pathogenomics.ca

The Pathogenomics of Innate Immunity, or PI2, project is a Genome Canada-funded project studying the mammalian innate immune system - the body's first line of defense against a range of bacteria, viral and other pathogens. Through the use of microarrays, mouse embryonic stem cell knockouts, siRNA, and bioinformatics, the project's aim is to understand key pathways and decision points in this important biological process.

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pathogenomics.ca pathogenomics.ca
1

Pathogenomics of Innate Immunity (PI2): A Genome Canada Project

http://www.pathogenomics.ca/index.php

Dr Robert E.W.Hancock, Professor of Microbiology and Immunology at UBC, and Dr. Lorne Babiuk, Professor of Veterinary Microbiology at the University of Saskatchewan, are leading the PI2 project, which will draw upon many of the unique research findings of a previous Genome Canada project, the Functional Pathogenomics of Mucosal Immunity Program. 2006 Pathogenomics of Innate Immunity: A GenomeBC Project.

2

Pathogenomics of Innate Immunity (PI2): Resources

http://www.pathogenomics.ca/resources.php

A description of many of the protocols implemented in the PI2 project is hosted at the Hancock Lab Website. Freely available software used in and developed by members of the PI2 project includes:. And is described in the manuscript Barsky A, Gardy JL, Hancock REW, Munzner T. Cerebral: a Cytoscape plugin for layout of and interaction with biological networks using subcellular localization annotation. Bioinformatics 2007 Apr 15;23(8):1040-2. PMID: 17309895. And is described in the manuscript Hokamp K, Roch...

3

Pathogenomics of Innate Immunity (PI2): Links

http://www.pathogenomics.ca/links.php

An excellent collection of links to tools that is searchable, organized by category, annotated, and constantly updated is the UBC Bioinformatics Centre's Bioinformatics Links Directory. The links below will take you to the UBiC Links Category for a subset of these links that are especially relevent to PI2 project members. Search the Bioinformatics Links Directory. Protein Interactions, Pathways and Enzymes. Sequence Retrieval and Submission. 2006 Pathogenomics of Innate Immunity: A GenomeBC Project.

4

Pathogenomics of Innate Immunity (PI2): Team

http://www.pathogenomics.ca/team.php

FRSC, OC ( web. Director, Centre for Microbial Diseases and Immunity Research. University of British Columbia. Vancouver, BC, Canada. Director, Vaccine and Infectious Disease Organization. Saskatoon, SK, Canada. GE3LS Ethics ( web. Senior Research Associate, W. Maurice Young Centre for Applied Ethics. University of British Columbia. Vancouver, BC, Canada. Mucosal immunology ( web. Director, Vaccine and Infectious Disease Organization. Saskatoon, SK, Canada. Cellular immunology ( web. Edmonton, AB, Canada.

5

Pathogenomics of Innate Immunity (PI2): Presentations

http://www.pathogenomics.ca/presentations.php

Talks given by PI2 researchers from 2006 onward:. Hancock REW. Discovery to Commercialization. Genome BC 4th Annual Genomics Forum, Apr 7, 2006, Vancouver, BC, Canada. Brinkman FSL. Trends in microbial protein networks and their evolution. Mathematical Biology Seminar Series, Mar 22, 2006, Vancouver, BC, Canada. Hancock REW. American Gastroenterology Association Host Microbial Symposium, Mar 24-26, 2006, San Diego, CA, USA. Brinkman FSL. Critical and integrative microarray data analysis. Mookherjee N, Br...

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cmdr.ubc.ca cmdr.ubc.ca

Centre for Microbial Diseases and Immunity Research

http://www.cmdr.ubc.ca/food

The Centre for Microbial Diseases and Immunity Research. University of British Columbia. Vancouver, British Columbia, Canada. Novel Approaches to Infectious Diseases and Host Defences". Search CMDR and UBC. Due to a planned electrical shut-down by UBC for required utility work, the CMDR server will be off line on Saturday November 11, 2006 from approximately 7 am- 9 pm. During this time, access to CMDR web pages will not be available. Questions or problems with these web pages?

pseudomutant.pseudomonas.com pseudomutant.pseudomonas.com

Pseudomonas aeruginosa PAO1 transposon mutant database

http://pseudomutant.pseudomonas.com/view.html

Functional Pathogenomics of Mucosal Immunity.

pseudomutant.pseudomonas.com pseudomutant.pseudomonas.com

Pseudomonas aeruginosa PAO1 transposon mutant database

http://pseudomutant.pseudomonas.com/methods.html

Functional Pathogenomics of Mucosal Immunity. Mutant Construction and Transposon Insertion Mapping. The mini-Tn5-lux transposon was delivered to. PAO1 by conjugation with the donor strain. S17-1 lambda-pir (pUTmini-Tn5-luxCDABE-Tc) (Winson. 1998) Biparental mating mixtures of the donor and recipient (1:2) were incubated on LB agar for 6-8 hours at 37°C. Cells were resuspended in PBS and plated onto large 22 X 22 cm LB agar plates containing 50 µg/ml tetracycline (Tc) to select for.

pseudomutant.pseudomonas.com pseudomutant.pseudomonas.com

Pseudomonas aeruginosa PAO1 transposon mutant database

http://pseudomutant.pseudomonas.com/index.html

Functional Pathogenomics of Mucosal Immunity. To search the transposon mutant database. Figure 1: PAO1 mini-TN. Transposon Mutant Library Statistics. Samples Processed Through Inverse PCR. Insertions Within a Gene.

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Pathogenomics of Innate Immunity (PI2): A Genome Canada Project

Dr Robert E.W.Hancock, Professor of Microbiology and Immunology at UBC, and Dr. Lorne Babiuk, Professor of Veterinary Microbiology at the University of Saskatchewan, are leading the PI2 project, which will draw upon many of the unique research findings of a previous Genome Canada project, the Functional Pathogenomics of Mucosal Immunity Program. 2006 Pathogenomics of Innate Immunity: A GenomeBC Project.

pathogenomics.net pathogenomics.net

Pathogenomics of Innate Immunity (PI2): A Genome Canada Project

Dr Robert E.W.Hancock, Professor of Microbiology and Immunology at UBC, and Dr. Lorne Babiuk, Professor of Veterinary Microbiology at the University of Saskatchewan, are leading the PI2 project, which will draw upon many of the unique research findings of a previous Genome Canada project, the Functional Pathogenomics of Mucosal Immunity Program. 2006 Pathogenomics of Innate Immunity: A GenomeBC Project.

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Pathogenomics of Innate Immunity (PI2): A Genome Canada Project

Dr Robert E.W.Hancock, Professor of Microbiology and Immunology at UBC, and Dr. Lorne Babiuk, Professor of Veterinary Microbiology at the University of Saskatchewan, are leading the PI2 project, which will draw upon many of the unique research findings of a previous Genome Canada project, the Functional Pathogenomics of Mucosal Immunity Program. 2006 Pathogenomics of Innate Immunity: A GenomeBC Project.

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