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The PML Consortium is a joint effort to enhance the understanding of and identify more effective methods of predicting, preventing and treating PML.

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Home - PML Consortium | pmlconsortium.org Reviews

https://pmlconsortium.org

The PML Consortium is a joint effort to enhance the understanding of and identify more effective methods of predicting, preventing and treating PML.

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Sitemap - PML Consortium

https://pmlconsortium.org/sitemap

About the PML Consortium. Talking with Your Doctor. About the PML Consortium. Current and Past Grants.

2

Featured Information - PML Consortium

https://pmlconsortium.org/featured-information

About the PML Consortium. The PML Consortium Website: A Resource for Patients, Caregivers and Health Care Professionals. Visitors may also learn more about the Consortium’s activities and progress through this website: the vision and mission of the organization, a summary of its initiatives, information about selected meetings, and FAQs are all addressed in "About the PML Consortium." As the Consortium takes on new initiatives and makes progress in expanding the body of knowledge about PML, upd...We hope...

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Vision and Mission - PML Consortium

https://pmlconsortium.org/about-pmlc/vision-and-mission

About the PML Consortium. Current and Past Grants. Progressive multifocal leukoencephalopathy (PML) is a serious but rare (in the general population) infection of the central nervous system (CNS) which can and often does lead to severe disability or death. PML is caused by the simultaneous occurrence of a common virus known as JC virus combined with additional risk factors including a compromised immune system, use of certain prescription medications, and possibly genetic factors.

4

What is PML? - PML Consortium

https://pmlconsortium.org/healthcare-professionals/what-is-pml

About the PML Consortium. Progressive multifocal leukoencephalopathy (PML) is a rare (in the general population) but serious demyelinating disease of the brain, often resulting in severe disability or death, caused by lytic infection of oligodendrocytes by the JC polyomavirus (JCV). Recent data about the prevalence of JCV exposure in the general population is limited. However, a 2009 study of 400 healthy blood donors showed 58% of the study population to have been exposed,. PML prognosis varies depending...

5

What is PML? - PML Consortium

https://pmlconsortium.org/patients-families/what-is-pml

Talking with Your Doctor. About the PML Consortium. Progressive multifocal leukoencephalopathy (PML) is, in the general population, a rare but serious infection of the central nervous system (CNS) that can and usually does lead to severe disability or death. It is caused by the combination of a common infection by a virus known as JC virus, (John Cunningham virus) and additional risk factors that include a weakened immune system and possibly genetic factors. Cancer, such as lymphoma. Disclaimer: The info...

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pmlregistry.ninds.nih.gov pmlregistry.ninds.nih.gov

PML Information | Progressive Multifocal Leukoencephalopathy

https://pmlregistry.ninds.nih.gov/Home/AnnualReport

Report of Findings from PML Registry. FAQs about this Registry. A summary of results from this patient registry will be available here in the future. Please check back. Request access to the PML registry (username and password for healthcare providers). FAQs about this Registry. PML Study at NIH. Patient Advocacy Group (Deferno Trust).

pmlregistry.ninds.nih.gov pmlregistry.ninds.nih.gov

PML Information | Progressive Multifocal Leukoencephalopathy

https://pmlregistry.ninds.nih.gov/Home/Publications

Report of Findings from PML Registry. FAQs about this Registry. Molecular Biology, Epidemiology, and Pathogenesis of Progressive Multifocal Leukoencephalopathy, the JC Virus-Induced Demyelinating Disease of the Human Brain. Author: Ferenczy MW, Marshall LJ, Nelson CDS, Atwood WJ, Nath A, Khalili K, Major EO: Clin Microbiol Rev 2012, 3:471-506. PMID: 22763635. Predicting Risk of Progressive Multifocal Leukoencephalopathy from Natalizumab. Case definition for progressive multifocal leukoencephalopathy foll...

pmlregistry.ninds.nih.gov pmlregistry.ninds.nih.gov

PML Information | Progressive Multifocal Leukoencephalopathy

https://pmlregistry.ninds.nih.gov/Home/Dictionary

Report of Findings from PML Registry. FAQs about this Registry. Brain Biopsy or biopsy pathologic confirmation of JC virus (JCV) infection in astrocytes and oligodendrocytes by immunohistochemistry or in situ DNA hybridization. Clinical symptom presentation compatible with PML,. Brain magnetic resonance imaging (MRI) findings consistent with PML,. JCV DNA detected in cerebrospinal fluid by polymerase chain reaction (PCR) assay. Probable Case (2 of 3 must apply). Brain MRI findings consistent with PML.

pmlregistry.ninds.nih.gov pmlregistry.ninds.nih.gov

PML Information | Progressive Multifocal Leukoencephalopathy

https://pmlregistry.ninds.nih.gov/Home/FAQ

Report of Findings from PML Registry. FAQs about this Registry. Frequently Asked Questions About this Registry. Who can enter data in this registry and how? Any healthcare provider (physician, nurse practitioner or physician assistant) who treats patients with PML can enter data. If you have never used this registry before, you need to first obtain a login. Please click the Login Request For Healthcare Providers link on the right or on the top. How will the information collected in this registry be used?

pmlregistry.ninds.nih.gov pmlregistry.ninds.nih.gov

PML Information | Progressive Multifocal Leukoencephalopathy

https://pmlregistry.ninds.nih.gov/Home/Committee

Report of Findings from PML Registry. FAQs about this Registry. The steering committee has developed the objectives and policies of this registry and oversees the use of collected data for research. Eugene O. Major Ph.D., Committee Chair. Chief, Laboratory of Molecular Medicine and Neuroscience (LMMN),. National Institute of Neurological Disorders and Stroke (NINDS), Bethesda, MD. Allen J. Aksamit M.D.,. Professor of Neurology,. Avindra Nath M.D.,. Leonard Calabrese D.O.,. Camille Kotton M.D.,.

pmlregistry.ninds.nih.gov pmlregistry.ninds.nih.gov

PML Information | Progressive Multifocal Leukoencephalopathy

https://pmlregistry.ninds.nih.gov/Home/Index

Report of Findings from PML Registry. FAQs about this Registry. WHAT IS THE PURPOSE OF THIS REGISTRY? Request access to the PML registry (username and password for healthcare providers). FAQs about this Registry. PML Study at NIH. Patient Advocacy Group (Deferno Trust).

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Home - PML Consortium

PML is a rare but serious infection of the central nervous system (CNS). The Progressive Multifocal Leukoencephalopathy (PML) Consortium is a joint effort between Pfizer, MedImmune, Roche, and Bristol-Myers Squibb intended to find methods to enable prediction and prevention of PML associated with immunomodulatory and immunosuppressive treatments. Recording Available: The Role of Consortia in Addressing Rare Adverse Events.

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