practicalfragments.blogspot.com
Practical FragmentsThis blog is meant to allow Fragment-based Drug Design Practitioners to get together and discuss NON-CONFIDENTIAL issues regarding fragments.
http://practicalfragments.blogspot.com/
This blog is meant to allow Fragment-based Drug Design Practitioners to get together and discuss NON-CONFIDENTIAL issues regarding fragments.
http://practicalfragments.blogspot.com/
TODAY'S RATING
>1,000,000
Date Range
HIGHEST TRAFFIC ON
Sunday
LOAD TIME
0.4 seconds
PAGES IN
THIS WEBSITE
20
SSL
EXTERNAL LINKS
130
SITE IP
172.217.10.129
LOAD TIME
0.375 sec
SCORE
6.2
Practical Fragments | practicalfragments.blogspot.com Reviews
https://practicalfragments.blogspot.com
This blog is meant to allow Fragment-based Drug Design Practitioners to get together and discuss NON-CONFIDENTIAL issues regarding fragments.
practicalfragments.blogspot.com
Practical Fragments: Fragments vs DDR1/2: a chemical probe
http://practicalfragments.blogspot.com/2015/07/fragments-vs-ddr12-chemical-probe.html
This blog is meant to allow Fragment-based Drug Design Practitioners to get together and discuss NON-CONFIDENTIAL issues regarding fragments. Fragments vs DDR1/2: a chemical probe. Was about the utility of chemical probes: small molecules with sufficient potency and selectivity to be able to address specific biological questions. A recent paper. In ACS Med. Chem. Lett. The researchers started with a thermal shift assay. Of the kinase, but around 10 bound in the so-called “ back pocket. And it had low act...
Practical Fragments: Silver Ain't Bad
http://practicalfragments.blogspot.com/2015/08/silver-aint-bad.html
This blog is meant to allow Fragment-based Drug Design Practitioners to get together and discuss NON-CONFIDENTIAL issues regarding fragments. For those of you who have been reading this blog for a while, you are familiar with the "Fragments in the Clinic" posts, Jan2015. Two of those slowly making its way through the pipeline is navitoclax, ABT-263, and venetoclax, ABT-199. Today Abbvie and Genentech announced. Great work - but whats its PFI? August 13, 2015 4:32 AM. August 14, 2015 10:53 AM. Fragments v...
Practical Fragments: Introducing the Chemical Probes Portal
http://practicalfragments.blogspot.com/2015/07/introducing-chemical-probes-portal.html
This blog is meant to allow Fragment-based Drug Design Practitioners to get together and discuss NON-CONFIDENTIAL issues regarding fragments. Introducing the Chemical Probes Portal. Chemical probes can be incredibly powerful reagents for understanding biology. A potent, selective, and cell-active modulator of a specific protein can be invaluable for figuring out what that protein actually does. Fragment-based methods can be effective at identifying these tool compounds, as we've described here. It should...
Practical Fragments: The Value of DSF
http://practicalfragments.blogspot.com/2015/08/the-value-of-dsf.html
This blog is meant to allow Fragment-based Drug Design Practitioners to get together and discuss NON-CONFIDENTIAL issues regarding fragments. The Value of DSF. Science is based upon incremental advances of previous work. A year ago, Dan blogged. About worked on BioA. The key take home from that work was that a hydrazine fragment ended up destabilizing the target by 18C. It ended up being, as expected, a reversible, SAM-competitive inhibitor with modest potency. As Dan concluded:. Little correlation betwe...
Practical Fragments: Who's Reviewing this Crap?
http://practicalfragments.blogspot.com/2014/06/whos-reviewing-this-crap.html
This blog is meant to allow Fragment-based Drug Design Practitioners to get together and discuss NON-CONFIDENTIAL issues regarding fragments. Who's Reviewing this Crap? Dan and I teach a short course. On FBDD; next chance to catch a version in October. My favorite part of Dan's section is when he goes off on PAINS and the continuing pollution. Well, here is our first PAINS Shaming. This paper. Pointed out by Matt Netherton at B-I, thanks Matt! Because rhodanines as a class are known to often have activit...
TOTAL PAGES IN THIS WEBSITE
20
First world war dysentery bug was penicillin-resistant | Chemistry and Life
https://michaelhparker.wordpress.com/2014/11/08/first-world-war-dysentery-bug-was-penicillin-resistant-health-07-november-2014-new-scientist
Medicinal chemistry. Pharmacology. Toxicology. Environmental sciences. First world war dysentery bug was penicillin-resistant. November 8, 2014. By Michael H. Parker. Here’s an interesting story about drug resistant bacteria from before the first antibacterial agents were discovered:. First world war dysentery bug was penicillin-resistant – New Scientist. One thought on “ First world war dysentery bug was penicillin-resistant. Aww Black And White Couple Cute Dog Image 412081 On Favim Com. Next Post →.
About | Chemistry and Life
https://michaelhparker.wordpress.com/about
Medicinal chemistry. Pharmacology. Toxicology. Environmental sciences. Michael H. Parker is a PhD research chemist with an interest in the ways that chemical compounds interact with biological systems – medicinal chemistry, pharmacology, toxicology, and environmental sciences. 2 thoughts on “ About. February 19, 2017 at 3:19 am. Are there any natural medications or substances that are successful in helping people with depression? Michael H. Parker. February 20, 2017 at 1:38 am. Leave a Reply Cancel reply.
Michael H. Parker | Chemistry and Life
https://michaelhparker.wordpress.com/author/michaelhparker
Medicinal chemistry. Pharmacology. Toxicology. Environmental sciences. Author Archives: Michael H. Parker. November 23, 2015. By Michael H. Parker. If your dietary supplement is advertised to work as well as a pharmaceutical, it may be adulterated with one. That failed clinical trials or were dropped from development for various reasons (maybe toxicity, unacceptable side effects, etc) or never even advanced into clinical trials. Examples include acetildenafil, aildenafil, and thiosildenafil. Unsc...Color...
Periodic Table Battleship | Chemistry and Life
https://michaelhparker.wordpress.com/2015/06/24/periodic-table-battleship
Medicinal chemistry. Pharmacology. Toxicology. Environmental sciences. June 24, 2015. By Michael H. Parker. This is a cute idea for kids:. Leave a Reply Cancel reply. Enter your comment here. Fill in your details below or click an icon to log in:. Email (Address never made public). You are commenting using your WordPress.com account. ( Log Out. You are commenting using your Twitter account. ( Log Out. You are commenting using your Facebook account. ( Log Out. Notify me of new comments via email.
Can an old hallucinogen be a new antidepressant? | Chemistry and Life
https://michaelhparker.wordpress.com/2015/01/07/can-an-old-hallucinogen-be-a-new-antidepressant
Medicinal chemistry. Pharmacology. Toxicology. Environmental sciences. Can an old hallucinogen be a new antidepressant? January 7, 2015. By Michael H. Parker. Ketamine is an anesthetic and sedative drug developed in the 1960s. It’s not widely used anymore, primarily because there are better options. Among its side effects are dissociative and hallucinogenic effects. Because of these effects, ketamine has also been used as recreational drug with the street name “Special K”. Leave a Reply Cancel reply.
If your dietary supplement is advertised to work as well as a pharmaceutical, it may be adulterated with one | Chemistry and Life
https://michaelhparker.wordpress.com/2015/11/23/if-your-dietary-supplement-is-advertised-to-work-as-well-as-a-pharmaceutical-it-may-be-adulterated-with-one
Medicinal chemistry. Pharmacology. Toxicology. Environmental sciences. If your dietary supplement is advertised to work as well as a pharmaceutical, it may be adulterated with one. November 23, 2015. By Michael H. Parker. That failed clinical trials or were dropped from development for various reasons (maybe toxicity, unacceptable side effects, etc) or never even advanced into clinical trials. Examples include acetildenafil, aildenafil, and thiosildenafil. Unscrupulous supplement manufacturers ha...Http:...
Molecular Design: January 2015
http://fbdd-lit.blogspot.com/2015_01_01_archive.html
The focus of this blog is molecular design which can be defined as control of the behavior of compounds and materials by manipulation of molecular properties. Sometimes vampires get staked and soucouyants get salted. Adv Drug Deliv Rev. Hypothesis driven molecular design. In Silico Medicinal Chemistry. Facebook FBDD and Molecular Design Group. Drug Mergers Hurt in Every Direction (Save One). A most enjoyable headline. Thermodynamics for medicinal chemistry design. Those who cannot predict.discover? It...
sussexdrugdiscovery.wordpress.com
October | 2014 | Sussex Drug Discovery Centre
https://sussexdrugdiscovery.wordpress.com/2014/10
Sussex Drug Discovery Centre. Medicinal, Chemistry and Biochemistry blog from the Sussex Drug Discovery Centre. Skip to primary content. Skip to secondary content. Sussex Drug Discovery Centre. Monthly Archives: October 2014. Alzheimer’s in a dish’ – A 3D cell culture model of Alzheimer’s disease. October 20, 2014. This month a group in the US have published an elegant study. Amyloid-β deposits in control (ReN-G) and FAD ReN (ReN-mGAP). This important work has not only provided experimental evidence supp...
sussexdrugdiscovery.wordpress.com
November | 2014 | Sussex Drug Discovery Centre
https://sussexdrugdiscovery.wordpress.com/2014/11
Sussex Drug Discovery Centre. Medicinal, Chemistry and Biochemistry blog from the Sussex Drug Discovery Centre. Skip to primary content. Skip to secondary content. Sussex Drug Discovery Centre. Monthly Archives: November 2014. In Silico Prediction of Off Target Activities of Chemical Probes. A recent publication highlights the importance of assessing broad selectivity and describes an in silico approach capable of predicting off target liabilities ( Antolín and Mestres, ACS Chemical Biology 2014, ahead o...
TOTAL LINKS TO THIS WEBSITE
130
Linux, BSD, Android, LEDE, OpenWRT, Free & Open Source Software
Linux, BSD, Android, LEDE, OpenWRT, Free and Open Source Software. Having fun with Open Source and Technology. Jul 8, 2016. Solving ARV7510PW22 overheating issue. As I started testing LEDE/OpenWrt in ARV7510PW22. For the first time I noticed it overheats more than accepatble and its WIFI for some reason gets stuck and sometimes gets disabled after a few minutes of usage. At first, I suspected its RaLink Wifi chip but after a few tests it turned out an overheating issue. Links to this post. May 28, 2016.
UBM Tech, the business technology network
Thank you for visiting one of UBM Tech's websites. This website is currently under maintenance and construction. Please follow one of the links below:. FEATURED UBM TECH SITES:. Game and App Development. Contact Us / Feedback.
practicalfractals.com - Registered at Namecheap.com
This domain is registered at Namecheap. This domain was recently registered at Namecheap. Please check back later! This domain is registered at Namecheap. This domain was recently registered at Namecheap. Please check back later! The Sponsored Listings displayed above are served automatically by a third party. Neither Parkingcrew nor the domain owner maintain any relationship with the advertisers.
practicalfragments.blogspot.com
Practical Fragments
This blog is meant to allow Fragment-based Drug Design Practitioners to get together and discuss NON-CONFIDENTIAL issues regarding fragments. Thirteenth Annual Fragment-based Drug Discovery Meeting. I’ll just try to give a few impressions. What struck me most was the number of success stories, several involving clinical compounds. Last year we highlighted Pfizer’s discovery of a chemical probe against ketohexokinase ( KHK. A few years back we highlighted. Huifen Chen told “the convoluted journey of...
The Practical Free Spirit | Amy Sundberg's Blog
The Practical Free Spirit. Amy Sundberg's Blog. Top Reads of 2017. December 14, 2017 by Amy Sundberg. Well, hello again! I’ve been taking a break from blogging after struggling with health issues post-car accident, but it is time to talk about books. I cannot miss an opportunity to talk about books with you all! My Favorite Volume of Poetry:. Night Sky with Exit Wounds, by Ocean Vuong. The Grand Sophy, by Georgette Heyer. Honestly it’s between this one and. The Undateable, by Sarah Title. This novel is q...
practicalfreightderivatives.com
practicalfreightderivatives.com - Registered at Namecheap.com
This domain is registered at Namecheap. This domain was recently registered at Namecheap. Please check back later! This domain is registered at Namecheap. This domain was recently registered at Namecheap. Please check back later! The Sponsored Listings displayed above are served automatically by a third party. Neither Parkingcrew nor the domain owner maintain any relationship with the advertisers.
