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Project team
http://www.macrophage.info/project-rus-10b05/project-team.html
Project ERA.Net RUS. International researcher team include life sciences professionals from Germany and Russia. Intensive communication guarantees seamless functioning of the team mutual visits and exchage program is indispensible from expetise transfer. Prof Dr. Julia Kzhyshkowska. Medical Factuly Mannheim, Ruprecht-Karls Universtiy of Heidelberg. 68167 Mannheim, Germany. Tel 49 621 383 2440. Fax 49 621 383 3815. E-mail. julia.kzhyshkowska(at)umm.de. Prof Dr. Alexander N Orekhov. 121609, Moscow, Russia.
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Development of novel diagnostic test system for cardio-metabolic disorders and cancer based on chitinase-like proteins
http://www.macrophage.info/project-era-net-rus/project-summary.html
Project ERA.Net RUS. Development of novel diagnostic test system for cardio-metabolic disorders and cancer based on chitinase-like proteins. Validation of the diagnostic value of the CLP-based detection system will be performed on the cohorts of patients with different stages of atherosclerosis, type 2 diabetes and cancer. Figure 1. Family of mammalian chitinases and chitinase-like proteins (CLP).
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Recommended literature
http://www.macrophage.info/new-page-2/literature.html
Project ERA.Net RUS. Gordon,S. and P.R.Taylor. 2005. Monocyte and macrophage heterogeneity. Nat. Rev. Immunol. 5: 953-964. Burke,B. and C.E.Lewis. 2002. The Macrophage, Second Edition ed. Oxford University Press, Oxford. Gratchev,A., J.Kzhyshkowska, K.Kothe, I.Muller-Molinet, S.Kannookadan, J.Utikal, and S.Goerdt. 2006. Mphi1 and Mphi2 can be re-polarized by Th2 or Th1 cytokines, respectively, and respond to exogenous danger signals. Immunobiology 211: 473-486. Gratchev,A., P.Guillot, N.Hakiy...Gratchev,...
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Project results
http://www.macrophage.info/project-rus-10b05/projects-results.html
Project ERA.Net RUS. Project results will be posted after 15.02.2012.
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Protocols
http://www.macrophage.info/new-page-2/ptotocols.html
Project ERA.Net RUS. This protocol is used in our lab to reduce the costs of the cell sorting with MACS reagents. The cell suspension obtained after this protocol contains 40-70% monocytes. This cell suspension is than used for positive or negative MACS separation. Buffy coats to be used for this protocol must be fresh and produced without platelet depletion. The volume of buffy coat that we obtain from Red Cross is usually about 75 ml. Note: PBS should be without Ca2 and Mg2! Mix in 50 ml tube. 135 ml P...
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Macrophages
http://www.macrophage.info/new-page.html
Project ERA.Net RUS. Whenever the organism enjoys immunity, the introduction of infectious microbes is followed by the accumulation of mobile cells, of white corpuscles of the blood in particular which absorb the microbes and destroy them. The white corpuscles and the other cells capable of doing this have been designated "phagocytes", i.e. devouring cells, and the whole function that ensures immunity has been given the name of "phagocytosis". Ilya Mechnikov, Nobel Lecture, Dec 11, 1908.
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Macrophages
http://www.macrophage.info/new-page-2.html
Project ERA.Net RUS.
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Project summary
http://www.macrophage.info/project-rus-10b05/project_summary.html
Project ERA.Net RUS.