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Protein ReEvolution - Corporate Details

http://protein-reevolution.com/corporate-details

Protein Computation / Simulation. UK Company No: 07650511. St John's Innovation Centre. Tel: 44 (0) 560 1078911. Fax: 44 (0) 560 1078911. You can reach us on:. 44 (0) 560 1078911. St John's Innovation Centre. This website was created using 1&1 MyBusiness Site.

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Protein ReEvolution - Protein Computation / Simulation

http://protein-reevolution.com/protein-computation-simulation

Protein Computation / Simulation. Protein Computation / Simulation. Targeted Solutions for Protein Performance Enhancement. Frequently Asked Questions (FAQs). 1 What methods are available to study the dynamic properties of proteins? Computational methods for detailed computer-based simulations are based on molecular dynamics, molecular mechanics and Gaussian network models. More detailed information about these methods are available on these websites:. 3 How can you be sure that the results obtained with...

3

Protein ReEvolution - Example ReEvolved Proteins

http://protein-reevolution.com/example-reevolved-proteins

Protein Computation / Simulation. High-throughput mutagenesis of the catalytic centre of the complex protein RNA Polymerase based on 500 individual systematically site-directed mutations. Point mutants increased the catalytic activity of the enzyme complex by up to 240%. The most active mutant enzyme complex was produced by replacing a methionine residue at position 808 with a proline residue. This non-intuitive result was predicted by ReEvolution’s in silico protein modelling . In the heat map below the...

4

Protein ReEvolution - Our services

http://protein-reevolution.com/our-services

Protein Computation / Simulation. Protein ReEvolution services include. Simulation of protein structures on a high-performance computing cluster to study the molecular dynamic properties of enzymes to guide mutagenesis target selection. Saturation mutagenesis by sequential permutation of entire protein domains for the systematic identification of variants displaying enhanced function using high-throughput robotics. If applicable, in vitro assembly of multi-subunit protein complexes. You can reach us on:.

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Protein ReEvolution - Home

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Protein Computation / Simulation. Protein Computation / Simulation. You can reach us on:. 44 (0) 560 1078911. St John's Innovation Centre. This website was created using 1&1 MyBusiness Site.

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Protein Computation / Simulation. Nature evolved proteins for specific metabolic purposes;. Protein ReEvolution will ReEvolve any protein for your specific commercial application. Proteins are critical components in medicine, biotechnology and industrial processes and products. In most cases the proteins used are those provided by nature, often produced in recombinant form. Nature’s proteins are adequate for their intended tasks, but were evolved to fulfil a specific, typically metabolic, natural purpose.

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