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The potentials of a novel add-on therapy. Lysine restriction has been shown by our proof of principle study (van Karnebeek, Hartmann et al; Molec Genet Metab 2012;107:335-44). To reduce neurotoxic metabolites and improve, seizure control, behavior and/or psychomotor development. However more evidence is required before diet becomes mainstay therapy. If you have signed up and received login details, you can enter the registry directly via the link below. Better unravel PDE disease mechanisms. Ensure that ...

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