radiolabeling.org

Radiolabeling and Isotopic Markers

Radiolabeling and Isotopic Markers. This website focuses on the isotopes primarily of interest to organic chemists, which include the non-metal Main Group elements. Once prepared, radiolabeled compounds meet a variety of fates, but the goal is ultimately to detect the labeled molecule, fragment or metabolite: a suitable radiolabel or isotopic marker should allow normal chemical or biochemical processes to be monitored without causing any interference.

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Radiolabeling and Isotopic Markers | radiolabeling.org Reviews

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Radiolabeling and Isotopic Markers. This website focuses on the isotopes primarily of interest to organic chemists, which include the non-metal Main Group elements. Once prepared, radiolabeled compounds meet a variety of fates, but the goal is ultimately to detect the labeled molecule, fragment or metabolite: a suitable radiolabel or isotopic marker should allow normal chemical or biochemical processes to be monitored without causing any interference.

<META> KEYWORDS

1 topics

2 introduction

3 nomenclature

4 purpose

5 synthetic methods

6 hydrogen isotopes

7 carbon isotopes

8 pnictides

9 chalcogenes

10 halogens

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topics,introduction,nomenclature,purpose,synthetic methods,hydrogen isotopes,carbon isotopes,pnictides,chalcogenes,halogens,analytical methods,safety and precautions,loss of label,storage,disposal,more information,literature,imprint

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Radiolabeling and Isotopic Markers | radiolabeling.org Reviews

https://radiolabeling.org

Radiolabeling and Isotopic Markers. This website focuses on the isotopes primarily of interest to organic chemists, which include the non-metal Main Group elements. Once prepared, radiolabeled compounds meet a variety of fates, but the goal is ultimately to detect the labeled molecule, fragment or metabolite: a suitable radiolabel or isotopic marker should allow normal chemical or biochemical processes to be monitored without causing any interference.

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radiolabeling.org

1

www.radiolabeling.org - Imprint

http://www.radiolabeling.org/div/imprint.htm

Matthew Schlecht, PhD, Newark, Delaware 19711, USA. Email: matthew [dot] f [dot] schlecht [at] gmail [dot] com*. Date of Publication: Feb. 7th, 2011. 4446 Buckten - Switzerland. Email address for general enquiries. We do not sell or buy chemicals.

2

Radiolabeling and Isotopic Markers - Introduction

http://www.radiolabeling.org/theory

Radiolabeling and Isotopic Markers - Introduction. This article focuses on the isotopes primarily of interest to organic chemists, which include the non-metal Main Group elements. The isotopes of metals within the Main Group, as well as alkali metals, alkaline earths, transition metals, lanthanides and actinides have many important applications in medicine, geology, inorganic chemistry, but are outside the scope of this discussion. The nuclei considered here are listed in the table below. Only very small...

3

Radiolabeled Compounds - Safety and Precautions

http://www.radiolabeling.org/theory/safety.htm

Except in specific case where an exchange reaction is being studied, the isotopic marker should not be in a labile functional group that is easily exchanged under normal conditions, such as deuterium (. H) or tritium (. H) in place of an alcoholic, phenolic or acidic OH, or a. O as a carbonyl oxygen in an aqueous environment, since the label will be readily washed out. Or Ar; storage at low temperatures ( -80 C); storage as a solution (alcohols, especially ethanol, and acetonitrile are good solvents, wat...

4

Radiolabeling and Isotopic Markers - Literature

http://www.radiolabeling.org/theory/literature.htm

B Långström, T. Kihlberg, Bergström, et al., Acta Chem. Scand. P M Miller, N. J. Long, R. Vilar, A.D. Gee , Angew. Chem. Int. Ed. C S Elmore, Ann. Rep. Med. Chem. M Braya, M. Di Masciob, F. de Kok-Mercadoa, et al., Antiviral Research. D E Armstrong, A. C. Briesmeister, B. B. McInteer, R. M. Potter Los Alamos National Laboratory Report #LA-4391. Feb 18, 1970). Y Himeda, S. Miyazawa, N. Onozawa-Komatsuzaki, et al., J. Chem. Soc. Dalton Trans. R H Seevers, R. E. Counsell, Chem. Rev. J Heilmann, K. G&#46...

5

Radiolabeling - Analytical Methods

http://www.radiolabeling.org/theory/analysis.htm

Scintillation-based methods have typically been preferred for the detection of radiolabels both due to the sensitivity, and also due to the difficulties in handling contamination from sample spillage inside an instrument such as an NMR spectrometer. In radiation-based imaging techniques, the radiolabeled compound is administered to the patient and emissions are recorded on film or digitally using a counter array. C before moving to the diagnostic scenario. The organic isotopes used in PET are:.

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Word Alchemy Technical Translation, Writing & Editing

http://wordalchemytranslation.com/Writing_Samples.html

Excerpt from Molecular Modeling on the PC. M F Schlecht, Wiley-VCH (New York) 1998, pp 3-10. Glossary of Computer and. Excerpt from Molecular Modeling on the PC. M F Schlecht, Wiley-VCH (New York) 1998, pp 658-663. Of Molecular Modeling on the PC. In J Chem. Educ. M F Schlecht, in McGraw-Hill Encyclopedia of Science and Technology. Ed S Parker), 9th edition, Vol. 4, pp 623-625,. McGraw-Hill (New York) 2002. M F Schlecht, in Comprehensive Organic Synthesis. Eds B M. Trost. And I Fleming), Vol.

organische-chemie.ch

Organic Chemistry

http://www.organische-chemie.ch/en/organic-chemistry.htm

Portal für Organische Chemie. In addition to the content here, the Organic Chemistry Portal. Offers additional features exclusively in English:. Is a free online journal that publishes short reviews on topics such as organic, bioorganic, organometallic and microwave chemistry and total synthesis of natural products. Of articles about recent synthesis methods, published in highly regarded organic chemistry journals. A graphical index for browsing synthetic transformations. The OSIRIS Property Explorer.

geigercounter.org

Hazardous isotopes: Cesium-137, Iodine-131, Strontium-90

http://www.geigercounter.org/radioactivity/isotopes.htm

Our focus here is on the isotopes cesium-137, strontium-90 and iodine-131, since they are relatively volatile and thus can contaminate large areas. In addition, it is these isotopes that accounted for most of the harmful effects following the Chernobyl nuclear accident in 1986. Cesium-137 arises as a cleavage product in the nuclear fission of uranium. Cesium-137 reacts further as a β. The main problem with cesium-137, which is present in the form of salts, is its high water solubility. Cesium-137 ion...

medchem.rutgers.edu

Graduate Program in Medicinal Chemistry - Web-Based Resources for Synthesis

http://medchem.rutgers.edu/synthesis.shtml

Graduate Program in Medicinal Chemistry. Electronic encyclopedia of reagents for organic synthesis. An on-line version of the complete Organic Syntheses series searchable by structure or text. Not Voodoo-Demystifying Synthetic Organic Chemistry Laboratory Technique. Tips, how-to advice, etc. for synthetic chemists. That allows the user to predict drug-like properties. Total Synthesis of Natural Products. A seminar presented by Kevin Jantzi, University of Wisconsin. Preparation of organolithium reagents.

intl-isotope-soc.org

International Isotope Society / LINKS

http://www.intl-isotope-soc.org/links

Other Chemistry Web Sites. Journal of Labelled Compounds and Radiopharmaceuticals. American Association of Pharmaceutical Scientists. American Chemical Society, Publications. ACS Division of Medicinal Chemistry. ACS Division of Organic Chemistry. American Association for the Advancement of Science. ChemCenter-ACS Electronic Bookmark for Chemistry. Royal Society of Chemistry. Society of Nuclear Medicine. Society of Non-Invasive Imaging in Drug Development. Radiolabeling and Isotopic Markers.

radioaktive-strahlung.org

Gefährlichen Isotope: Cäsium-137, Iod-131, Strontium-90

http://www.radioaktive-strahlung.org/radioaktivitaet/isotope.htm

Wir fokussieren uns auf die Isotope Cäsium-137, Strontium-90 und Iod-131, da sie relativ flüchtig sind und deshalb grosse Flächen kontaminieren können. Zudem hat man ihnen die grösste Schadwirkung nach dem atomaren Unfall von Tschernobyl zugesprochen. Cäsium-137 entsteht als Spaltprodukt bei der Kernspaltung von Uran. Cäsium-137 reagiert als β. Das Hauptproblem bei Cäsium-137, das in Form von Salzen vorliegt, ist seine hohe Wasserlöslichkeit. Die Cäsium-137-Ionen verteilen sich daher gut im Körper un...

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Radiolabeling and Isotopic Markers

Radiolabeling and Isotopic Markers. This website focuses on the isotopes primarily of interest to organic chemists, which include the non-metal Main Group elements. Once prepared, radiolabeled compounds meet a variety of fates, but the goal is ultimately to detect the labeled molecule, fragment or metabolite: a suitable radiolabel or isotopic marker should allow normal chemical or biochemical processes to be monitored without causing any interference.

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