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regulatorygenomicsgroup.org

Regulatory Genomics Group

The website of Regulatory Genomics Group at Babraham Institute. Group leader - Dr Mikhail Spivakov

http://www.regulatorygenomicsgroup.org/

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Regulatory Genomics Group | regulatorygenomicsgroup.org Reviews
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Regulatory Genomics Group | regulatorygenomicsgroup.org Reviews

https://regulatorygenomicsgroup.org

The website of Regulatory Genomics Group at Babraham Institute. Group leader - Dr Mikhail Spivakov

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1

People « Regulatory Genomics Group

http://regulatorygenomicsgroup.org/people

112;aula.freire-pritchett. I am very interested in understanding how gene expression in multicellular organisms is regulated in time and space. I find it fascinating how cells can trigger very different responses to a variety of input signals. Postdoc (jointly with Nuclear Dynamics ISP). 104;ashem.koohy. I am using machine learning to understand gene regulation and lymphocyte development. Postdoc (jointly with Peter Fraser group at Nuclear Dynamics ISP). 109;jthiecke. Qian combined wet-lab and computatio...

2

Group photos « Regulatory Genomics Group

http://regulatorygenomicsgroup.org/people/group-photos

May 2016: Churchill formal. Group members and partners at Churchill college formal hall, hosted by Lina. Left to right: top – Michiel, Sven, Hashem, Jonathan; bottom – Jo, Lina, Paula, Mikhail). Aug 2015: Group retreat. Science discussions in the morning…. 8230;bubble football in the afternoon! Feb 2015: St Catharine’s formal. With members of Peter Fraser’s group and friends at St Catharine’s college formal hall – hosted by Erin!

3

About Mikhail « Regulatory Genomics Group

http://regulatorygenomicsgroup.org/about-mikhail

Mikhail Spivakov graduated from Department of Biology at Moscow State University in 2002 and moved to London to do a PhD with Amanda Fisher and Matthias Merkenschlager at MRC Clinical Sciences Centre (Imperial College). His PhD projects investigated chromatin events underlying cell differentiation, and about half of his work was ‘wet-lab’ and half computational. In November 2012, Mikhail started a Regulatory Genomics group at the Babraham Institute as part of the Nuclear Dynamics Programme.

4

Publications « Regulatory Genomics Group

http://regulatorygenomicsgroup.org/publications

Wingett SW, Várnai C, Dimond A, Plagnol V, Zerbino D, Schoenfelder S, Javierre B-M, Osborne C, Fraser P, Spivakov M. CHiCAGO: Robust Detection of DNA Looping Interactions in Capture Hi-C data. Genome Biology. 2016. 17:127. Bolland DJ* / Koohy H*. Wood AL, Matheson LS, Krueger F, Stubbington MJT, Baizan-Edge A, Chovanec P, Stubbs BA, Tabbada K, Andrews SR, Spivakov M. Corcoran AE . Two Mutually Exclusive Local Chromatin States Drive Efficient V(D)J Recombination. Genome Biology. 2016. 17:152. Blood 2016&#...

5

CHiCAGO « Regulatory Genomics Group

http://regulatorygenomicsgroup.org/chicago

CHiCAGO: Capture HiC Analysis of Genomic Organisation. CHiCAGO is a set of tools for calling significant interactions in Capture HiC data, such as Promoter Capture HiC. The statistical foundations of CHiCAGO. CHiCAGO uses a convolution background model. Accounting for both random ‘ Brownian collisions. Between chromatin fragments (that are distance-dependent) and ‘ technical noise. It borrows information across interactions. CHiCAGO then performs a p-value weighting. 33 release (requires R version = 3&#4...

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Welcome to Regulatory Genomics Group! We study the logic and robustness of gene regulation. Our favourite experimental models are mammalian development and ageing and our focus is on computational analyses. Group leader: Dr Mikhail Spivakov. We are part of Nuclear Dynamics Programme. In Cambridge, UK. We use advanced machine learning and data mining in our analyses, but our main focus is on the biological question and the properties of a biological system we study. More on what we do.

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