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Science Overview Replicor is a clinical-stage company developing novel NUCLEIC ACID-BASED POLYMERS (NAPs): oligonucleotides whose antiviral activity is strictly dependent on the polymer chemistry of oligonucleotides which can be preserved independently of the sequence of nucleotides present. NAPs have a very important safety advantage over all other existing oligonucleotide-based drugs such as aptamers, antisense oligonucleotides …

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Science Overview Replicor is a clinical-stage company developing novel NUCLEIC ACID-BASED POLYMERS (NAPs): oligonucleotides whose antiviral activity is strictly dependent on the polymer chemistry of oligonucleotides which can be preserved independently of the sequence of nucleotides present. NAPs have a very important safety advantage over all other existing oligonucleotide-based drugs such as aptamers, antisense oligonucleotides &hellip;
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1 science
2 hepatitis b
3 hepatitis d
4 nap technology
5 scientific advisory board
6 collaborative network
7 publications
8 conference presentations
9 pipeline
10 layperson’s guide
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Home | Replicor | replicor.com Reviews

https://replicor.com

Science Overview Replicor is a clinical-stage company developing novel NUCLEIC ACID-BASED POLYMERS (NAPs): oligonucleotides whose antiviral activity is strictly dependent on the polymer chemistry of oligonucleotides which can be preserved independently of the sequence of nucleotides present. NAPs have a very important safety advantage over all other existing oligonucleotide-based drugs such as aptamers, antisense oligonucleotides &hellip;

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1

Latest News | ReplicorReplicor announces publication of its REP 101 and REP 102 studies demonstrating the therapeutic effect of NAPs and the achievement of functional control off treatment in human patients with chronic hepatitis B infection. | Replicor

http://replicor.com/about-us/news

August 2, 2016. Replicor announces publication of its REP 101 and REP 102 studies demonstrating the therapeutic effect of NAPs and the achievement of functional control off treatment in human patients with chronic hepatitis B infection. June 7, 2016. Replicor announces publication of its REP 101 and REP 102 studies demonstrating the therapeutic effect of NAPs and the achievement of functional control off treatment in human patients with chronic hepatitis B infection. April 4, 2016. February 16, 2016.

2

Publications | Replicor

http://replicor.com/science/publications

Peer Reviewed Publications on Replicor's NAP Technology. Nucleic acid polymers: Broad spectrum antiviral activity, antiviral mechanisms and optimization for the treatment of hepatitis B and hepatitis D infection. Vaillant A. Antiviral Research 2016 133: 32-40. Safety and Efficacy of Nucleic Acid Polymers in Monotherapy and Combined with Immunotherapy in Treatment-Naive Bangladeshi Patients with HBeAg Chronic Hepatitis B Infection. Al-Mahtab M, Bazinet, M, Vaillant A. PLOS ONE 2016 11: e0156667. Matsumura...

3

Investors | Replicor

http://replicor.com/about-us/investors

Replicor is a privately funded company. The company is well supported by shareholders that include two New York-based institutional investors.

4

Management | Replicor

http://replicor.com/about-us/team

Michel Bazinet, M.D. CEO and Chief Medical Officer. Andrew Vaillant, Ph.D. Matthieu Blanchet, Ph.D. Director of Scientific Collaborations. Léo Bazinet, B.A.A. Mr Bazinet has 30 years of experience in administration, marketing and finance in the private sector. He has a Bachelor’s Degree in Business Administration from the University of Quebec in Montreal.

5

Hepatitis D | Replicor

http://replicor.com/science/hepatitis-d

Hepatitis D, also called hepatitis delta, affects 15 to 20 million patients worldwide and is the most deadly of all forms of hepatitis. HDV infection is always associated with chronic hepatitis B infection (HBV) since the HDV virus needs the surface membrane proteins of the HBV virus (HBsAg) to complete the formation of the HDV virus. NAPs have the potential to be effective against HBV / HDV co-infection. It is expected that the persistence of HBsAg in patients with chronic HDV infection prevents an opti...

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350 million people have chronic hepatitis B. We’re developing the cure. Replicor has focused its efforts on developing a cure for HBV and HDV. Three POC Phase II clinical trials have demonstrated that NAP therapy (including REP 2139-Ca with immunotherapy (Pegasys or Zadaxin ) is well tolerated and results in antiviral responses that include:. The elimination (up to. Reduction to LLOQ) of HBsAg in the blood seroconversion for both HBsAg and HBeAg. The elimination (up to 6.

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