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Clinical Bioinformatics Blog – using biology to learn informatics

using biology to learn informatics

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Clinical Bioinformatics Blog – using biology to learn informatics | saffyb.wordpress.com Reviews
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Clinical Bioinformatics Blog – using biology to learn informatics | saffyb.wordpress.com Reviews

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using biology to learn informatics

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Comparing Sequences – Clinical Bioinformatics Blog

https://saffyb.wordpress.com/2015/11/15/comparing-sequences

November 15, 2015. November 15, 2015. A gene’s protein sequence can be used to compare the human gene to its counterpart. In other organisms. Comparative analysis of the same gene from multiple species is an approach for identifying variations that are unique for a given organism ( Frazer et al., 2003. Sequence similarities and differences can also suggest regions that are significant to the gene’s functioning ( Sievers et al., 2011. Gene Conservation and Consensus. ASPA Gene Sequence Comparison. Can be ...

2

November 2015 – Clinical Bioinformatics Blog

https://saffyb.wordpress.com/2015/11

November 22, 2015. November 22, 2015. An important element of normal biological development is gene regulation. The process of turning genes on and off. Gene regulation controls gene expression. The transcription of a gene’s DNA to mRNA and assembly of a protein molecule. Genes are expressed, or turned on and off, at different phases of development. This enables cells to differentiate. DNA Methylation and Epigenetics. DNA methylation is an epigenetic. As depicted in the graphic. Below ( Phillips, 2008.

3

August 2015 – Clinical Bioinformatics Blog

https://saffyb.wordpress.com/2015/08

August 30, 2015. August 30, 2015. ASPA is the gene symbol for Aspartoacylase (Gene/Locus MIM number 608034). An alternative title and symbol for this gene is Aminoacylase 2; ACY2. The ASPA gene is localized to human chromosome 17. Canavan disease (Phenotype MIM number 271900) is caused by mutation in the gene encoding aspartoacylase, ASPA. The clinical features of Canavan disease are:. Onset in early infancy. Weakness of neck muscles. Flexion of arms – arms are bent. Average age of death is 18 months.

4

Diagnostic Genome Analysis – Clinical Bioinformatics Blog

https://saffyb.wordpress.com/2015/11/08/diagnostic-genome-analysis

November 8, 2015. November 12, 2015. Tacik et al., 2015). The general public can also obtain personal genetic information, including disease predisposition and ancestry information, from companies that offer testing services. However, it is important to understand that genetic testing is not a simple tool but a complex practice (Buchbinder and Timmermans, 2011). Whole Genome Sequencing (WGS). Summarizes how a DNA sample is fragmented, sequenced, and assembled for reference comparison. Direct-to-consumer ...

5

3D Visualization – Clinical Bioinformatics Blog

https://saffyb.wordpress.com/2015/11/01/3d-visualization

November 1, 2015. November 1, 2015. Visualization of a gene’s 3-dimensional protein structure is useful for rational drug design. Drugs are designed by identifying a molecular target then screening thousands to millions of compounds for effects. This graphic created by the Department of Molecular Biophysics and Biochemistry at Yale University summarizes the process of rational drug discovery. Using 3D imaging of protein structures to virtually screen molecular targets (. ASPA GENE: 3D PROTEIN STRUCTURE.

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Clinical Bioinformatics Blog – using biology to learn informatics

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