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ADAMTS13(a disintegrin-like and metalloproteinase with thrombospondin type 1 motifs 13). Von Willebrand因子(VWF)切断酵素(VWF-cleaving protease, VWF-CP)とも呼ばれる.血小板凝集能の高い超高分子量VWFマルチマーを切断して低分子量化することで,止血反応を調節する. 血漿に約1μg/mLで存在する190 kDaの糖蛋白質であり,分泌型亜鉛メタロプロテアーゼであるADAMTSファミリーに属する.VWFのTyr1605-Met1606間を切断する. 遺伝子は染色体9q34に存在し,29個のエキソンからなる.翻訳された1,427アミノ酸残基のポリペプチドからシグナル配列とプロペプチドが除去され,細胞外へ分泌される.ディスインテグリン様ドメイン,トロンボスポンジン1型モチーフなど,多くのドメイン構造をもつ. 活性測定には, FRETS-VWF73を基質とする蛍光法や,モノクローナル抗体を用いるELISA法が主に用いられている。 VEGF は血管の内側にある内皮細胞の受容体 (fl...