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4401 E●●●●●●e Mall

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Animal Data - Satiogen Pharmaceuticals

http://www.satiogen.com/AnimalData.html

Harnessing the Bile Acid Brake for Therapy of Diabesity. To date Satiogen has completed 18 preclinical studies, the goals of which were to demonstrate the metabolic effects of targeting colorectal TGR5 receptors with bile acid and to build the company’s patent estate. Following are snapshots of the results:. Cumulative food intake is reduced in rats rectally instilled with taurocholate-containing gel ( TCA dotted lines) and control rats (solid lines). For more information, contact info@satiogen.com.

2

Home - Satiogen Pharmaceuticals

http://www.satiogen.com/index.html

Harnessing the Bile Acid Brake for Therapy of Diabesity. Satiogen Pharmaceuticals has discovered a metabolic mechanism of action termed the bile acid brake that is a novel target for treating type 2 diabetes and obesity without intervention by systemically absorbed pharmaceuticals or invasive surgical methods. Since starting in 2007 Satiogen has operated as a virtual company focused on demonstrating proof-of-concept and crafting a patent estate. This intralumenal, nonsystemic mechanism of action offers i...

3

People - Satiogen Pharmaceuticals

http://www.satiogen.com/People.html

Harnessing the Bile Acid Brake for Therapy of Diabesity. Satiogen has been operating as a virtual company without employees or formal management team. Wing individuals have played central roles in the company’s progress:. Andrew Young, MD, PhD,. Conceived of the bile acid brake as a mechanism for treating diabesity, founded Satiogen, and personally funded its earliest exploratory research and patent filings. He holds several patents directed to using the hormone amylin in diabetes therapy. Before startin...

4

Human Data - Satiogen Pharmaceuticals

http://www.satiogen.com/2.html

Harnessing the Bile Acid Brake for Therapy of Diabesity. Satiogen has completed one clinical study of rectally administered bile acid, and the company is sponsoring a second study now underway. The completed study is being prepared for publication, so it cannot yet be shown here. Following is the abstract of the data presented at the American Diabetes Association meeting in June 2010:. The Bile Acid Brake: A Novel Target for Treating Diabetes and Obesity. Triggered via TGR5 membrane receptors. The pr...

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Home - Satiogen Pharmaceuticals

Harnessing the Bile Acid Brake for Therapy of Diabesity. Satiogen Pharmaceuticals has discovered a metabolic mechanism of action termed the bile acid brake that is a novel target for treating type 2 diabetes and obesity without intervention by systemically absorbed pharmaceuticals or invasive surgical methods. Since starting in 2007 Satiogen has operated as a virtual company focused on demonstrating proof-of-concept and crafting a patent estate. This intralumenal, nonsystemic mechanism of action offers i...

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