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Welcome to ScieIntl; Leading science enabling breakthrough applications.

ScieIntl’s science and technologies represent paradigm-changing advances in contemporary as well as traditional drug discovery. They also pave the way for breakthroughs in biofuels production and other industrial enzymatic processes. ScieIntl’s technologies enable the discovery of low molecular weight compounds that:. Have simultaneous high affinity to multiple targets, or. Increase an enzyme’s catalytic rate. Their superior capabilities significantly minimize discovery expenditures. Trend setting therap...

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Welcome to ScieIntl; Leading science enabling breakthrough applications. | scieintl.com Reviews

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ScieIntl’s science and technologies represent paradigm-changing advances in contemporary as well as traditional drug discovery. They also pave the way for breakthroughs in biofuels production and other industrial enzymatic processes. ScieIntl’s technologies enable the discovery of low molecular weight compounds that:. Have simultaneous high affinity to multiple targets, or. Increase an enzyme’s catalytic rate. Their superior capabilities significantly minimize discovery expenditures. Trend setting therap...

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2 public domain shortcomings

3 science

4 stochastic affinity rescaling

5 macromolecular energy redistribution

6 technologies

7 performance

8 applications

9 pharmaceutical applications

10 biofuels applications

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Welcome to ScieIntl; Leading science enabling breakthrough applications. | scieintl.com Reviews

https://scieintl.com

ScieIntl’s science and technologies represent paradigm-changing advances in contemporary as well as traditional drug discovery. They also pave the way for breakthroughs in biofuels production and other industrial enzymatic processes. ScieIntl’s technologies enable the discovery of low molecular weight compounds that:. Have simultaneous high affinity to multiple targets, or. Increase an enzyme’s catalytic rate. Their superior capabilities significantly minimize discovery expenditures. Trend setting therap...

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scieintl.com

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ScieIntl; Science & Technologies; Science

http://www.scieintl.com/science.php

ScieIntl’s proprietary scientific breakthroughs are the foundations of our technologies. Stochastic Affinity Rescaling (StAR). This theory integrates the dynamics and statistical thermodynamics of the multiple microscopic binding events into the thermodynamics of macroscopically observed binding affinities. The ensuing mathematical relationships elicit vastly superior predictive performance relative to prevalent state of the art public domain methods. Spectrum of Target Activities (SpecTA).

2

ScieIntl; Applications; Biofuels Applications

http://www.scieintl.com/biofuelsapplication.php

ScieIntl’s technologies enable the discovery of small molecule enzyme activators that increase catalytic rate of enzymes involved in the conversion of starch and lignocellulosic biomass to ethanol. Presently, the manufacturing process to convert starch to ethanol has a throughput of several days per batch of ethanol. Doubling the process rate increases manufacturing throughput, minimizing manufacturing costs. PO Box 16125, Greensboro, NC, 27261.

3

Welcome to ScieIntl; Leading science enabling breakthrough applications.

http://www.scieintl.com/index.php

ScieIntl’s science and technologies represent paradigm-changing advances in contemporary as well as traditional drug discovery. They also pave the way for breakthroughs in biofuels production and other industrial enzymatic processes. ScieIntl’s technologies enable the discovery of low molecular weight compounds that:. Have simultaneous high affinity to multiple targets, or. Increase an enzyme’s catalytic rate. Their superior capabilities significantly minimize discovery expenditures. Trend setting therap...

4

ScieIntl; Applications; Pharmaceutical Applications

http://www.scieintl.com/pharmaceuticalapplication.php

ScieIntl's technologies enable screening extensive chemical and target databases to identify and optimize leads into preclinical candidates. They enable the:. Discovery of high affinity ligands that simultaneously inhibit multiple targets. Discovery of compounds that activate and increase the catalytic rates of enzymes. Discovery of high affinity ligands that inhibit a single targets. Highly cost-effective resource utilization. PO Box 16125, Greensboro, NC, 27261.

5

ScieIntl; Science & Technologies; Public Domain Shortcomings

http://www.scieintl.com/publicdomainshortcomings.php

Publicly available forcefields and scoring functions used in preclinical lead generation and lead optimization suffer significant predictive shortcomings. The situation is bleaker in lead optimization. Attempts to utilize prevalent public domain methods to predict affinities most frequently fail even for {single chemotype-single target} cases. They consistently fail in predicting the more challenging {multiple chemotypes-single target} and {multiple chemotypes-multiple targets} affinities. Th...ScieIntl’...

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Welcome to ScieIntl; Leading science enabling breakthrough applications.

ScieIntl’s science and technologies represent paradigm-changing advances in contemporary as well as traditional drug discovery. They also pave the way for breakthroughs in biofuels production and other industrial enzymatic processes. ScieIntl’s technologies enable the discovery of low molecular weight compounds that:. Have simultaneous high affinity to multiple targets, or. Increase an enzyme’s catalytic rate. Their superior capabilities significantly minimize discovery expenditures. Trend setting therap...

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