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Directed by Dr. Jonathan Sebat, and funded in part by a gift from the Beyster Family Foundation, our laboratory is interested in how rare and de novo mutations in the human genome contribute to risk for common psychiatric disorders such as autism and schizophrenia. To this end, we are developing novel approaches to gene discovery that are based on advanced technologies for the detection of rare variants, including studies of copy number variation (CNV) and deep whole genome sequencing (WGS). Our goal is to

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Directed by Dr. Jonathan Sebat, and funded in part by a gift from the Beyster Family Foundation, our laboratory is interested in how rare and de novo mutations in the human genome contribute to risk for common psychiatric disorders such as autism and schizophrenia. To this end, we are developing novel approaches to gene discovery that are based on advanced technologies for the detection of rare variants, including studies of copy number variation (CNV) and deep whole genome sequencing (WGS). Our goal is to

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1 Jonathan Sebat

2 Ph.D.; Copy Number Variation; CNV; Whole Genome Sequencing; de novo mutation; autism; schizophrenia; bioinformatics

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Directed by Dr. Jonathan Sebat, and funded in part by a gift from the Beyster Family Foundation, our laboratory is interested in how rare and de novo mutations in the human genome contribute to risk for common psychiatric disorders such as autism and schizophrenia. To this end, we are developing novel approaches to gene discovery that are based on advanced technologies for the detection of rare variants, including studies of copy number variation (CNV) and deep whole genome sequencing (WGS). Our goal is to

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sebatlab.ucsd.edu

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In the News

http://sebatlab.ucsd.edu/index.php/in-the-news

Spectrum: DNA flips and swaps 'scramble' genes linked to autism. Science Daily: Genetic changes that cause autism are more diverse than previously thought. UCSD TV: Human Origins- Lessons from Autism Spectrum Disorders. UCSD News: Genomic 'hotspots' offer clues to causes of autism, other disorders. NPR: Researchers Link Gene Mutation to Schizophrenia. NPR: Genetic Link to Schizophrenia Discovered. NPR: Cause of Autism Narrowed Down to 100 Genes. JSN Solid template designed by JoomlaShine.com.

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Software & Data

http://sebatlab.ucsd.edu/index.php/software-data

Software developed in our group. ForestSV 0.3.3.tar.gz. Rf 1KG ILMN BWA HG19 v1.Rdata. ForestDNM 0.2.tar.gz. ForestDNM HPCaller 0.1.tar.gz. Determining Parent of Origin. Data from our group. Illumina WGS dataset on 10 quad families, consisting of monozygotic twins concordant for ASD and their parents (Michaelson et al., Cell 2012) has been submitted to the National Database for Autism Research. They are bundled by chromosome, and each .Rdata file (an R workspace file) contains an Rle object.

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People

http://sebatlab.ucsd.edu/index.php/people

Jonathan Sebat, Ph.D. Director, Beyster Institute for Psychiatric Genomics. Professor of Psychiatry, Cellular and Molecular Medicine, and Pediatrics. This email address is being protected from spambots. You need JavaScript enabled to view it. Madusudan Gujral, Ph.D. Aniket Shetty, M.S. Danny Antaki, B.Sc. This email address is being protected from spambots. You need JavaScript enabled to view it. " target=" blank" style="font-family: Tahoma, sans-serif;" This email address is being protected from...This ...

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http://sebatlab.ucsd.edu/index.php

Autism is linked to rare mutations. Members of our group. New gene for schizophrenia identified. Members of our group. Autism is linked to rare mutations. Http:/ sebatlab.ucsd.edu/images/sebatlabimages/mutation1.jpg. Group1 10.28.15 A.jpg. Members of our group. Http:/ sebatlab.ucsd.edu/images/sebatlabimages/group1 10.28.15 A.jpg. New gene for schizophrenia identified. Http:/ sebatlab.ucsd.edu/images/sebatlabimages/neuron1.jpg. Group1 12.09.14.jpg. Members of our group. Dantaki 12.09.14.jpg. E are develop...

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Autism is linked to rare mutations. Members of our group. New gene for schizophrenia identified. Autism is linked to rare mutations. Http:/ sebatlab.ucsd.edu/images/sebatlabimages/mutation1.jpg. Group1 12.09.14.jpg. Members of our group. Http:/ sebatlab.ucsd.edu/images/sebatlabimages/group1 12.09.14.jpg. New gene for schizophrenia identified. Http:/ sebatlab.ucsd.edu/images/sebatlabimages/neuron1.jpg. Dantaki 12.09.14.jpg. Group5 12.09.14.jpg. Wbrandler2 A 12.09.14.jpg. Institute for Genomic Medicine.

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