The Silvaggi laboratory in the Department of Chemistry and Biochemistry at the University of Wisconsin-Milwaukee studies the relationships between structure and function in enzymes. We use X-ray crystallography, enzyme kinetics, site directed mutagensis and biophysical techniques like isothermal titration calorimetry.
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REBECCA SILVAGGI
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REBECCA SILVAGGI
1512 C●●●●●●ILL DR
ROC●●●ILL , SC, 29730
US
View this contact
REBECCA SILVAGGI
1512 C●●●●●●ILL DR
ROC●●●ILL , SC, 29730
US
View this contact
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The Silvaggi laboratory in the Department of Chemistry and Biochemistry at the University of Wisconsin-Milwaukee studies the relationships between structure and function in enzymes. We use X-ray crystallography, enzyme kinetics, site directed mutagensis and biophysical techniques like isothermal titration calorimetry.
silvaggi.com
Lab Intranet
http://www.silvaggi.com/index.php/intranet
Chemistry and Biochemistry at UWM. Jump to main navigation and login. Lab members log in here to access references, project data, and related resources.
Structural Enzymology Links
http://www.silvaggi.com/index.php/links
Chemistry and Biochemistry at UWM. Jump to main navigation and login. The Protein Data Bank. The Comprehensive Enzyme Information System. KEGG: Kyoto Encyclopedia of Genes and Genomes. Kyoto Encyclopedia of Genes and Genomes. Is a bioinformatics resource for linking genomes to life and the environment. SCOP: Structural Classification of Proteins. Nearly all proteins have structural similarities with other proteins and, in some of these cases, share a common evolutionary origin. The SCOP. CATH is a manual...
For the Public
http://www.silvaggi.com/index.php/public
Chemistry and Biochemistry at UWM. Jump to main navigation and login. In many ways, enzymes are very attractive catalysts for organic synthesis and are receiving a lot of attention in light of the industry focus on "Green Chemistry." Enzymes are highly specific for both particular molecules (their substrates) and particular. Read more: Enzyme Engineering. Read more: Undergraduate Research. Have you ever wondered where the medicines we use every day came from? Read more: Drug Design.
Publications
http://www.silvaggi.com/index.php/publications
Chemistry and Biochemistry at UWM. Jump to main navigation and login. G Neil Stowe, Peter Silhar, Mark S. Hixon, Nicholas R. Silvaggi. Karen N. Allen, Scott T. Moe, Alan R. Jacobson, Joseph T. Barbieri, and Kim D. Janda. 2010. Chirality Holds the Key for Potent Inhibition of the Botulinum Neurotoxin Serotype A Protease. Nicholas R. Silvaggi. David Wilson, Saul Tzipori, Karen N. Allen. Nicholas R. Silvaggi. Nicholas R. Silvaggi. Langdon J. Martin, Mark Nitz, Barbara Imperiali, Karen N. Allen. Antonio Llin...
Drug Design
http://www.silvaggi.com/index.php/public/50-graduate
Chemistry and Biochemistry at UWM. Jump to main navigation and login. Have you ever wondered where the medicines we use every day came from? Many drugs are discovered initially by high-throughput screening. This is a "shotgun" approach where literally tens or hundreds of thousands of small molecules (MW 500) are.
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Chemistry and Biochemistry at UWM. Jump to main navigation and login. To the Silvaggi group, located in the Department of Chemistry and Biochemistry at the University of Wisconsin-Milwaukee. The primary focus of this laboratory is the relationship between enzyme structure and function. In other words, how can enzymes with no apparent structural similarity catalyze exactly the same chemical reactions? Or, for that matter, how can two seeming identical enzymes catalyze very different reactions? In many way...
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