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Rakesh K. Jain, Director. Lance L. Munn. Annual Retreat, 2015. Museum of Science Boston. A major goal is to understand the mechanisms underlying the temporal and spatial heterogeneities in tumor vasculature by studying angiogenesis, vascular collapse, intermittent flow, and maturation of vascular networks. In the past 20 years, we made several technical innovations in imaging and transport measurements. Our laboratory has a long-standing tradition of novel technique development and application. New ways ...

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Steele Labs :: Home | steelelabs.mgh.harvard.edu Reviews

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Rakesh K. Jain, Director. Lance L. Munn. Annual Retreat, 2015. Museum of Science Boston. A major goal is to understand the mechanisms underlying the temporal and spatial heterogeneities in tumor vasculature by studying angiogenesis, vascular collapse, intermittent flow, and maturation of vascular networks. In the past 20 years, we made several technical innovations in imaging and transport measurements. Our laboratory has a long-standing tradition of novel technique development and application. New ways ...

<META> KEYWORDS

1 personnel

2 publications

3 manuscripts

4 covers

5 labs

6 yves boucher

7 dai fukumura

8 g dan duda

9 igor garkavtsev

10 peigen huang

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Steele Labs :: Home | steelelabs.mgh.harvard.edu Reviews

https://steelelabs.mgh.harvard.edu

Rakesh K. Jain, Director. Lance L. Munn. Annual Retreat, 2015. Museum of Science Boston. A major goal is to understand the mechanisms underlying the temporal and spatial heterogeneities in tumor vasculature by studying angiogenesis, vascular collapse, intermittent flow, and maturation of vascular networks. In the past 20 years, we made several technical innovations in imaging and transport measurements. Our laboratory has a long-standing tradition of novel technique development and application. New ways ...

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steelelabs.mgh.harvard.edu

1

Steele Labs :: Lab Base :: Pi Bio

https://steelelabs.mgh.harvard.edu/lance_munn/pi_bio

Munn, Lance, PhD. Flow of fluid within the lymphatic system is central to many aspects of physiology, including fluid homeostasis and immune function, and poor lymphatic drainage results in significant morbidity in millions of patients each year. We are investigating the mechanisms of lymphatic pumping, considering the nitric oxide and calcium dynamics driven by mechanobiological mechanisms. In many normal physiological responses, endothelial cells and the blood vessel networks they form undergo dramatic...

2

Steele Labs :: Lab Base :: Pi Bio

https://steelelabs.mgh.harvard.edu/dai_fukumura/pi_bio

Fukumura, Dai, MD, PhD. Angiogenesis and Microcirculation in Physiological and Pathophysiological Settings. The long-term goal of my research is to uncover the fundamental nature of vascular biology in both physiological and pathophysiological settings, and to utilize this knowledge for detection and treatment of diseases. Together with outstanding collaborators, I have been developing and utilizing state of the art imaging techniques and animal models which led to the discoveries summarize below. Rahbar...

3

Steele Labs :: Lab Base :: Pi Bio

https://steelelabs.mgh.harvard.edu/timothy_padera/pi_bio

Padera, Timothy, PhD. Pathophysiology of tumor associated lymphatic vessels and lymphatic metastasis. C, which is associated with lymphatic metastasis in patients, increases the size of the tumor margin lymphatic vessels, making them more vulnerable to invasion. Our data suggests that VEGF. C needs to be blocked very early in the metastatic process to be able to reduce VEGF. C enhanced lymphatic metastasis. Furthermore, we have shown that VEGFR. Our future studies will continue to dissect the physical an...

4

Steele Labs :: Tumor Course

https://steelelabs.mgh.harvard.edu/tumorcourse

Course Registration and Travel Information. Course Support and Accreditation. Critical Issues in Tumor Microenvironment: Angiogenesis, Metastasis and Immunology. September 5 – 8, 2017. Royal Sonesta Hotel, Cambridge, Massachusetts. Revised on 2016-10-11 22:21:45 UTC. 169; 2017 Edwin L. Steele Laboratories.

5

Steele Labs :: Publications

https://steelelabs.mgh.harvard.edu/publications

Rakesh K. Jain, Director. Lance L. Munn. Chen Y, Liu YC, Sung YC, Ramjiawan RR, Lin TT, Chang CC, Jeng KS, Chang CF, Liu CH, Gao DY, Hsu FF, Duyverman AM, Kitahara S, Huang P, Dima S, Popescu I, Flaherty KT, Zhu AX, Bardeesy N, Jain RK, Benes CH, Duda DG. Overcoming sorafenib evasion in hepatocellular carcinoma using CXCR4-targeted nanoparticles to co-deliver MEK-inhibitors. Sci Rep. 2017;7:44123 - PMID: 28276530. Zhang N, Gao X, Zhao Y, Datta M, Liu P, Xu L. Cancer. 2017;:ePub - PMID: 28192597. Gupta N,...

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Steele Labs :: Home

Rakesh K. Jain, Director. Lance L. Munn. Annual Retreat, 2015. Museum of Science Boston. A major goal is to understand the mechanisms underlying the temporal and spatial heterogeneities in tumor vasculature by studying angiogenesis, vascular collapse, intermittent flow, and maturation of vascular networks. In the past 20 years, we made several technical innovations in imaging and transport measurements. Our laboratory has a long-standing tradition of novel technique development and application. New ways ...

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