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StopRM.orgHere you can learn how to avoid introducing Reactive Metabolite problems into the drug design process.
http://www.stoprm.org/
Here you can learn how to avoid introducing Reactive Metabolite problems into the drug design process.
http://www.stoprm.org/
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StopRM.org | stoprm.org Reviews
https://stoprm.org
Here you can learn how to avoid introducing Reactive Metabolite problems into the drug design process.
stoprm.org
News Feeds | StopRM.org
http://www.stoprm.org/feeds
How to avoid introducing Reactive Metabolite problems into the drug design process. About & Contact. Patient safety, news and press releases from EMA. Fri, 02 Sep 2016 14:00:00 0000: News and press releases: Meeting highlights from the Pharmacovigilance Risk Assessment Committee (PRAC) 30 August - 2 September 2016. News and press releases. During its September meeting, the European Medicines Agency's (EMA) Pharmacovigilance Risk Assessment Committee (PRAC) discussed one ongoing safety referral. Health ca...
Presentations | StopRM.org
http://www.stoprm.org/presentations
How to avoid introducing Reactive Metabolite problems into the drug design process. About & Contact. Here is a list of useful presentations that will provide a good deal of background learning on the subject. Schneider, Rick (Pfizer), 2016. Piloting the progression of reactive metabolites through drug discovery. Royal Society of Chemistry, Maggi Churchouse events, 8-9th Feb. Claesson (Awametox Consulting), 2012. Reactive Metabolites – Hints How to Avoid a Drug Safety Hazard. Presentation.
SpotRM+ | StopRM.org
http://www.stoprm.org/spotrm
How to avoid introducing Reactive Metabolite problems into the drug design process. About & Contact. Previously, we mentioned here the application SpotRM, which was launched in 2012. This was replaced in February 2016 with the much more advanced tool SpotRM. Which highlights potential hazards in your drawn structure by matching it with a rich set of structural alerts that have proven or likely associations with adverse clinical events. It is also possible to perform text searches with key words.
Recent reviews on Reactive Metabolites | StopRM.org
http://www.stoprm.org/reviews
How to avoid introducing Reactive Metabolite problems into the drug design process. About & Contact. Reviews and Selected Papers on Reactive Metabolites. There are five categories. Focus on toxicological and strategy aspects. Focus on screening techniques. Papers on in vitro vs. in vivo data. Special aspects (eg carboxylic acids). Detecting reactive drug metabolites for reducing the potential for drug toxicity. Expert Opin Drug Metab Tox. Kalgutkar and Dalvie (Pfizer). Ann Rev Pharmacol Tox. KB Park et al.
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StopRM.org
How to avoid introducing Reactive Metabolite problems into the drug design process. About & Contact. Welcome to StopRM.org. Here you can learn how to avoid introducing Reactive Metabolite problems into the drug design process. Which allows you to search substructures or keywords to find out about the current hypotheses or proven mechanisms of RM formation of known drugs with RM problems. Contents on this page. Can we design drug candidates with no or less RM issues? Major classes of reactive metabolites.
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