We asked a question: Why did nature select a particular sequence for making proteins ? Did she try all genomic possibilities - approving some, keeping some in the wait list and rejecting others....
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We asked a question: Why did nature select a particular sequence for making proteins ? Did she try all genomic possibilities - approving some, keeping some in the wait list and rejecting others....
syntheticproteome.weebly.com
Team - synthetic prtoeo
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Department of Life Sciences. Shiv Nadar University (currently at Pasteur Institute, Paris). School of Biotechnology, Jawaharlal Nehru University, New Delhi. Interests: Bioprocess, Bioinformatics, Cheminformatics, CAD biology. Bioinformatics Scientist, Denmark. Interests: Hypothetical proteins, Synthetic Proteins. ACHUTHSANKAR S. NAIR. Department of Computational Biology and Bioinformatics. University of Kerala, Trivandrum. Biosequence Signal processing and compression, HMM. PAWAN K. DHAR.
Science - synthetic prtoeo
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Ecoli experiment Dhar et al (2009). To find novel anti-malarial peptides from the non-coding. DNA of certain organisms. Targets: AMA-1, EBA 175, MSP 1-19. Trains : 7G8, 3D7, Dd2. Describes initial predictions against P.falciparum targets. To find novel peptides / proteins against breast cancer cell lines. MCF7 and MDA-MB-231. Indo-Danish collaborative project submitted based on initial results. Goal: To find novel peptides / proteins against BACE 1 (Beta site APP. Create a free website.
Publications - synthetic prtoeo
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Making novel proteins from pseudogenes. Shidhi et al. Bioinformatics (Accepted). Finding novel drugs against Alzheimer’s from junk DNA. Navya et al. MS communicated. Discovering Novel Anti-Malarial Peptides from the Not-coding Genome - A Working Hypothesis. Current Synthetic Sys Biol 2013, 1:1. Joshi M, SV Kundapura, T Poovaiah, K Ingle, PK Dhar. Synthesizing non-natural parts from natural genomic template. J Biol Eng. 2009: 3, 2. Dhar PK, Thwin CS, Tun K, Maurer-Stroh S, Eisenhaber F, Tsumoto Y, Surana U.
Talks - synthetic prtoeo
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15 Designing and engineering biological systems. Spiez Convergence Workshop, Spiez, Switzerland, Oct 2014. 14 Emerging Synthetic biology trends in India. Organization for the Prohibition of Chemical Weapons, The Hague. Apr 2013. 13 Synthetic biology and biomediated synthesis of organic chemicals. National Academies of Sciences, USA - IUPAC, Speiz Laboratory, Zurich. Feb 2012. 12 The future in biology will be computation and engineering. Intel, Bangalore. Feb 2012. 10 Emerging Trends in Synthetic Biology.
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Science - Dhar Lab
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Make your own genes. Genome Designer - a bioCAD platform for synthetic biology. Kera - computer language for composing organisms. Create a free website. Create your own free website. Start your own free website. A surprisingly easy drag and drop site creator. Learn more.
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synthetic prtoeo - Home
We asked a question: Why did nature select a particular sequence for making proteins? Did she try all genomic possibilities - approving some, keeping some in the wait list and rejecting others. If she did not try all possibilities, can one artificially make genes from sequences that nature did not use for transcription. Furthermore, can one express Proteins from RNA coding sequences? What are the best case scenarios and boundary conditions? To address these questions, we invented a novel method.
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