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Butte Lab

From T cells to rare diseases. Our lab addresses fundamental and translational questions in immunology using advanced visualization and cellular manipulation. The fundamental focus. Is on understanding the molecular and biophysical controls that balance T cell activation versus tolerance. The translational focus. Understanding how mechanical forces and cytoskeletal controls influence immune responses. Technologies our lab uses include:. Biological atomic force microscopy (AFM). Stanford, CA 94305-5208.

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Butte Lab | tcell.stanford.edu Reviews
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From T cells to rare diseases. Our lab addresses fundamental and translational questions in immunology using advanced visualization and cellular manipulation. The fundamental focus. Is on understanding the molecular and biophysical controls that balance T cell activation versus tolerance. The translational focus. Understanding how mechanical forces and cytoskeletal controls influence immune responses. Technologies our lab uses include:. Biological atomic force microscopy (AFM). Stanford, CA 94305-5208.
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2 members
3 projects
4 basic immunology
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7 food allergy
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Butte Lab | tcell.stanford.edu Reviews

https://tcell.stanford.edu

From T cells to rare diseases. Our lab addresses fundamental and translational questions in immunology using advanced visualization and cellular manipulation. The fundamental focus. Is on understanding the molecular and biophysical controls that balance T cell activation versus tolerance. The translational focus. Understanding how mechanical forces and cytoskeletal controls influence immune responses. Technologies our lab uses include:. Biological atomic force microscopy (AFM). Stanford, CA 94305-5208.

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tcell.stanford.edu tcell.stanford.edu
1

Butte Lab Members

http://tcell.stanford.edu/members.html

Manish Butte, MD PhD. Assistant Professor, Department of Pediatrics. Stanford Community Academic Profile. Tim Thauland, PhD. Irina Gurevich, PhD. Sara Kleinman, MD. Post-doctoral Fellow, Allergy and Immunology 2nd year. PhD program in Biophysics. PhD program in Microbiology and Immunology. PhD program in Immunology. Marc A. Bruce, PhD. PhD in Immunology, 2009-2014. Currently CTO and Co-Founder, Microvolution LLC. Andrew Wang, PhD. Currently at Western Digital. Summer High School Student (SIMR 2016).

2

Butte Lab Publications

http://tcell.stanford.edu/publications.html

Kuipers HF, Rieck M, Gurevich I, Nagy N, Butte MJ, Negrin RS, Wight TN, Steinman L, Bollyky PL. Hyaluronan synthesis is necessary for autoreactive T-cell trafficking, activation, and Th1 polarization. PNAS. 2016 Feb 2;113(5):1339-44. Epub 2016 Jan 19. PMID: 26787861. Wang A*, Vijayraghavan K*, Solgaard O, Butte MJ. Fast Stiffness Mapping of Cells Using High-Bandwidth Atomic Force Microscopy. ACS Nano. 2016 Jan 26;10(1):257-64. Epub 2015 Dec 15. PMID: 26554581. Highlighted in Stanford Medicine magazine.

3

Butte Lab

http://tcell.stanford.edu/index.html

From T cells to rare diseases. Our lab addresses fundamental and translational questions in immunology. Of the lab blends our interests in mechanobiology (how cells make and sense mechanical forces) and regulation of the immune system in autoimmunity, cancer, and infection. The clinical and translational focus. Understanding how mechanical forces and cytoskeletal controls influence immune responses. We have pioneered the use of biological Atomic Force Microscopy. Stanford, CA 94305-5208. Mailing Packages...

4

Butte Lab Publications

http://tcell.stanford.edu/projects.html

Developing a fundamental understanding of T cell activation and tolerance. Mechanotransduction - the conversion of mechanical forces to biochemical signals has not been thoroughly studied in immune cells. It is our long-term goal to understand the biophysical basis of mechanotransduction in modulating T cell responses, which can strategically improve T cell functions in autoimmunity and cancer. How do mechanical signals modulate activation of T cells? Biology at the nanoscale. Ge X, Wang IE, Toma I, Seba...

5

Butte Lab Publications

http://tcell.stanford.edu/news.html

Oct '15 We received a grant from the Stanford Cardiovascular Research Institute to study T cells in adults with congenital heart disease. Sep '15 Welcome James Hardin, PhD student in Immunology, as a rotation student. He's working on a rare immune disease. Aug '15 We received a grant from the Stanford Child Health Research Institute to study T cells in children with congenital heart disease. The Actin Capping Protein Alpha-Adducin is Required for CD28 Costimulation. April '13 Welcome Ken Hu and Adi de la...

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Butte Lab

From T cells to rare diseases. Our lab addresses fundamental and translational questions in immunology using advanced visualization and cellular manipulation. The fundamental focus. Is on understanding the molecular and biophysical controls that balance T cell activation versus tolerance. The translational focus. Understanding how mechanical forces and cytoskeletal controls influence immune responses. Technologies our lab uses include:. Biological atomic force microscopy (AFM). Stanford, CA 94305-5208.

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