tmg.mgh.harvard.edu

ccib.mgh.harvard.edu

Center for Computational and Integrative Biology :: Ruvkun Lab

http://ccib.mgh.harvard.edu/ruvkun

Computational and Integrative Biology. Search for Extraterrestrial Genomes. The Ruvkun lab has explored two major themes: regulation by microRNA genes and other small RNAs, and control of longevity and metabolism by insulin and other endocrine pathways. Thousands of miRNAs have been discovered and are now implicated in control of gene expression of across eukaryotic phylogeny. Duplex to down-regulate translation. There is also increasing evidence of a cell biology of RNA.

ccib.mgh.harvard.edu

Center for Computational and Integrative Biology :: Freeman Lab

http://ccib.mgh.harvard.edu/freeman

Computational and Integrative Biology. Receptor deficient and apo E deficient mice in the C57/BL6 background form atherosclerotic lesions in the proximal aorta that share many characteristics of human atheroma. Early foam cell lesions followed by the development of complex, calcific plaques are generated in these animals. Recent studies have been examining the following questions:. Is scavenger receptor uptake of modified lipoproteins essential for lesion formation and progression?

ccib.mgh.harvard.edu

Center for Computational and Integrative Biology :: Seed Lab

http://ccib.mgh.harvard.edu/seed

Computational and Integrative Biology. A fraction of the lab is also engaged in the development of new therapeutic entities to treat human diseases. This effort is multidisciplinary and includes the development of technologies to address and correct acquired disorders as well as the creation of new biologicals and chemically modified hybrid biologicals. The majority of this effort is aimed at new approaches to treat tumors and metabolic conditions. Revised on 2013-02-13 17:57:38 UTC.

ccib.mgh.harvard.edu

Center for Computational and Integrative Biology :: Joung Lab

http://ccib.mgh.harvard.edu/joung

Computational and Integrative Biology. 149 13th Street, Room 6133. Charlestown, MA 02129 USA. The Joung Laboratory develops technologies for genome engineering using artificial “designer” DNA. Binding domains. We utilize engineered zinc finger, transcription activator-like effector ( TALE. Revised on 2013-02-25 14:47:02 UTC. 169; 2016 Center for Computational and Integrative Biology.

ccib.mgh.harvard.edu

Center for Computational and Integrative Biology :: Xavier Lab

http://ccib.mgh.harvard.edu/xavier

Computational and Integrative Biology. Revised on 2015-07-21 19:24:09 UTC. 169; 2016 Center for Computational and Integrative Biology.

ccib.mgh.harvard.edu

Center for Computational and Integrative Biology :: Ausubel Lab

http://ccib.mgh.harvard.edu/ausubel

Computational and Integrative Biology. Offer many advantages for the genetic analysis of host-pathogen interactions. Our laboratory pioneered the use of direct screens for identifying Arabidopsis mutants that exhibit aberrant responses to pathogen attack. Similarly, our Laboratory pioneered the development of. Pathogenicity models that have shown that. Our laboratory is now divided about 50/50 between the Arabidopsis and. Utilizes a shared subset of virulence factors to infect both plants and animals&#46...

ccib.mgh.harvard.edu

Center for Computational and Integrative Biology :: Lab Base :: Pi Bio

http://ccib.mgh.harvard.edu/tompkins/pi_bio

Computational and Integrative Biology. Ron Tompkins graduated Summa Cum Laude from Tulane University Medical School and holds a doctorate in chemical and biomedical engineering from the Massachusetts Institute of Technology. Dr Tompkins is the Chief of Burns Service at the Massachusetts General Hospital, is the Sumner M. Redstone Professor of Surgery at Harvard Medical School, and serves as the Chief of Staff of Shriners Hospital for Children in Boston. Selected Publications (from total of 390). The burn...

ccib.mgh.harvard.edu

Center for Computational and Integrative Biology :: Translational Medicine Group

http://ccib.mgh.harvard.edu/translational_medicine_group

Computational and Integrative Biology. The Translational Medicine Group. Is a program established with the goal of accelerating the advance of new therapeutics into clinical practice. The TMG. Works closely with the basic science teams in the CCIB. The CCIB’s lead program is an SGLT2 inhibitor for the treatment of diabetes mellitus that has been developed in conjunction with a biotech sponsor, Theracos Inc. The TMG. Has supervised the development of this compound from the time of selection of a pre-clini...

ccib.mgh.harvard.edu

Center for Computational and Integrative Biology :: Hung Lab

http://ccib.mgh.harvard.edu/hung

Computational and Integrative Biology. We are facing an incredible challenge in the realm of infectious diseases that has been brought on by the convergence of three current phenomena – newly emerging infectious organisms, a global crisis in antibiotic resistance, and the threat of bioterrorism. A response to this challenge requires a renewed devotion to understanding the underlying mechanisms involved in infection and an increased commitment to the discovery of new antibiotics.