todbase.org

TODbase: The Time of Death research data base

Time of Death database. TODbase) is an international cooperation to establish a database for time of death estimation based on hypoxanthine (Hx) and potassium (K) levels in vitreous humor (eye fluid). Through research conducted at Institute for Forensic Medicine, University of Oslo, hypoxanthine and potassium levels in vitreous humor have proven to be reliable biochemical markers for post-mortem interval determination. Last modified October 22, 2009.

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TODbase: The Time of Death research data base | todbase.org Reviews

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Time of Death database. TODbase) is an international cooperation to establish a database for time of death estimation based on hypoxanthine (Hx) and potassium (K) levels in vitreous humor (eye fluid). Through research conducted at Institute for Forensic Medicine, University of Oslo, hypoxanthine and potassium levels in vitreous humor have proven to be reliable biochemical markers for post-mortem interval determination. Last modified October 22, 2009.

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1 front page

2 general

3 introduction

4 science and methods

5 scientific basis

6 methods

7 todbase

8 history

9 collaborators

10 internal pages

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TODbase: The Time of Death research data base | todbase.org Reviews

https://todbase.org

Time of Death database. TODbase) is an international cooperation to establish a database for time of death estimation based on hypoxanthine (Hx) and potassium (K) levels in vitreous humor (eye fluid). Through research conducted at Institute for Forensic Medicine, University of Oslo, hypoxanthine and potassium levels in vitreous humor have proven to be reliable biochemical markers for post-mortem interval determination. Last modified October 22, 2009.

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todbase.org

1

TODbase: The Time of Death research data base

http://www.todbase.org/index.html

Time of Death database. TODbase) is an international cooperation to establish a database for time of death estimation based on hypoxanthine (Hx) and potassium (K) levels in vitreous humor (eye fluid). Through research conducted at Institute for Forensic Medicine, University of Oslo, hypoxanthine and potassium levels in vitreous humor have proven to be reliable biochemical markers for post-mortem interval determination. Last modified October 22, 2009.

2

Introduction: Time of death determination

http://www.todbase.org/intro.html

Introduction: Time of death determination. Norwegian Criminal Cases Review Commision. Wikipedia: List of miscarriage of justice cases. Eye fluid (vitreous humor) is a clear gel that fills the space between the lens and the retina of the eye (Wikipedia: vitreous humor. An international cooperation is now initiated to accelerate the research effort on the postmortem increase of these two biochemical markers (Dahlberg et al. Scand J Forens Sci 2009; 1: 38), in which TODbase is a central component. T...

3

About TODbase

http://www.todbase.org/about.html

From left, behind: Torleiv O. Rognum, Arne Stray-Pedersen, Anne Gunn Winge, Linda Ferrante, Anne Lise Lunde, Anne Grete Flønes, Siri H. Opdal, Sara Moberg, Ann Cathrin Larsen. In front: Musse A. Musse, Margrethe Abildgaard, Åshild Vege. TODbase has been set up by the Research group for experimental medicine at the Institute of Forensic Medicine, University of Oslo, lead by Torleiv Rognum. It also draws on additional resources from outside the group. Last modified October 22, 2009.

4

Scientific basis

http://www.todbase.org/basis.html

Diagram illustrating the accuracies of different time of death estimates against interval in which death is known to have taken place (tactical). The new standard curves have shown strong correlation with tactical observations in murder cases during the last 6 years. However, subgroups exist in which certain intrinsic and extrinsic factors affect the rate with which hypoxanthine levels increase, which is why the material needs further expansion. Last modified October 22, 2009.

5

Method for Time of death determination using hypoxanthine

http://www.todbase.org/method.html

Time of death determination using hypoxanthine. The vitreous humor is collected with 4.5 ml vacutainers. At the University of Oslo, we quantify hypoxanthine with capillary electrophoresis and potassium with an ion-selective electrode. HPLC may also be used for quantification of hypoxanthine. To our knowledge, simpler methods (such as enzyme assays) are not reliable. Last modified October 22, 2009.

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TODbase: The Time of Death research data base

Time of Death database. TODbase) is an international cooperation to establish a database for time of death estimation based on hypoxanthine (Hx) and potassium (K) levels in vitreous humor (eye fluid). Through research conducted at Institute for Forensic Medicine, University of Oslo, hypoxanthine and potassium levels in vitreous humor have proven to be reliable biochemical markers for post-mortem interval determination. Last modified October 22, 2009.

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