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toxpathspecialists.com

Tox Path Specialists, LLC

Home of Tox Path Specialists, LLC. Here for all of your neuropathology, neurohistology and stereology needs.

http://www.toxpathspecialists.com/

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Home of Tox Path Specialists, LLC. Here for all of your neuropathology, neurohistology and stereology needs.
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1 neuropathology
2 neurohistology
3 stereology /
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5 services
6 frozen
7 paraffin
8 resin
9 special stains
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Tox Path Specialists, LLC | toxpathspecialists.com Reviews

https://toxpathspecialists.com

Home of Tox Path Specialists, LLC. Here for all of your neuropathology, neurohistology and stereology needs.

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1

Tox Path Specialists

http://www.toxpathspecialists.com/about.html

The TPS lab provides the following services:. Specialized necropsy support, providing services that include intravascular perfusion, study design, fixative choice, and harvest of difficult to identify/obtain tissues. Specialized trimming of nervous system components including the brain, spinal cord, spinal nerve roots and associated ganglia, peripheral nerves and components of the autonomic nervous system. Specialized histochemical staining procedures. H&E for basic morphology. Luxol Fast Blue for myelin.

2

Tox Path Specialists | Resin Embedding

http://www.toxpathspecialists.com/resin_embedding.html

Standard paraffin embedded, H&E stained sections of nerves simply do not provide adequate detail to allow for a complete examination. This is well illustrated in the images on this page. The upper left image is a standard paraffin embedded, H&E stained cross-section of nerve; detail is lacking. The lower left image is a cross-section of nerve embedded in soft plastic (in this case, GMA). Without osmium fixation there is little, if any, advantage of this technique over standard paraffin. See our page on.

3

Tox Path Specialists

http://www.toxpathspecialists.com/paraffin.html

Paraffin embedding is the most commonly used histology technique in preclinical studies. TPS is capable of processing regular- and over-size (2x3) sections sections. Over-size sections are commonly used for full coronal/transverse brain sections of large laboratory animal species. Common tissues: almost any. Common stains: cytochemical stains, immunohistochemical stains.

4

Tox Path Specialists

http://www.toxpathspecialists.com/frozen_free_floating.html

Sliding microtome sections (typically used for some immunohistochemistry staining and also for stereologic investigations). Because of the flexibility of frozen sections (you can collect anything and keep the sections in a freezer for later use), investigations not possible in paraffin are a reality. Common stains: immunohistochemical stains.

5

Tox Path Specialists | Special Staining and Immunohistochemistry

http://www.toxpathspecialists.com/special_stains.html

Choline Acetyl Transferase (ChAT). Specific marker for cholinergic neurons in the brain and central nervous system. At TPS, this stain can be used for. In the brain (such as investigations of cholinergic neurons in the basal forebrain). Calcitonin Gene Related Peptide (CGRP). Glial Fibrillary Acidic Protein (GFAP). Ionized calcium Binding Adaptor molecule 1 (IBA-1). Neuronal Nuclear antigen (NeuN). Glial Fibrillary Acidic Protein (GFAP). Choline Acetyl Transferase (ChAT). Neuronal Nuclear antigen (NeuN).

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8th Toxicologic Pathology Workshop. IFSTP, IATP and STP-I webinar on Pathology Techniques in Rat Neurotoxicity Studies on May 11, 2015. Proceedings of third Toxicologic Pathology workshop. Proceedings of 4th conference, 1-3 November 2012. Proceeding of 5th Toxicologic Pathology workshop held at Vadodara on 14-15 September, 2013. Welcome to Society of Toxicologic Pathology-India (STPI). Society of Toxicologic Pathology - India is a registered society (Registration number:757/04-05).

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Tox Path Specialists, LLC

Welcome to Tox Path Specialists, LLC. Tox Path Specialists, LLC (TPS) is a fully GLP compliant provider of neuropathology evaluations and consultations. Company President and Founder, Dr. Mark T. Butt, consults with numerous global pharmaceutical and pathology companies. He is co-author/co-editor of. Fundamental Neuropathology for Pathologists and Toxicologists: Principles and Techniques. Dr Butt has over 20 years experience. The laboratory at TPS provides a wide range of. Embedded sections, numerous.

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160;    ToxPharm Consulting, LLC. 160;               Toxicology and Pharmacokinetics. Welcome to ToxPharm Consulting, LLC,. An independent consulting company providing scientific and. Regulatory guidance in the areas of:. 160;           . 160;           . 160;          . Regulatory Strategy and Safety Assessment. 183;            . Regulatory Submissions and Negotiations. 183;            . Study Design, Monitoring, Compliance, Reporting. 160;         .