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The Great Tragedy of Science

The Great Tragedy of Science. The slaying of a beautiful hypothesis by a single, ugly, fact. Tuesday, April 21, 2009. 3D architecture of the virological synapse and structural mechanisms of HIV entry - Sriram Subramaniam - National Institutes of Health. Sriram Subramaniam is head of the Biophysics Section of the Laboratory of Cell Biology and Senior Investigator at the NCI. Ion abrasion scanning electron microscopy to view 3D EM images of HIV-infected cells. Resolution of about 20nm! Ive cell imaging tha...

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The Great Tragedy of Science | tragicscience.blogspot.com Reviews

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The Great Tragedy of Science. The slaying of a beautiful hypothesis by a single, ugly, fact. Tuesday, April 21, 2009. 3D architecture of the virological synapse and structural mechanisms of HIV entry - Sriram Subramaniam - National Institutes of Health. Sriram Subramaniam is head of the Biophysics Section of the Laboratory of Cell Biology and Senior Investigator at the NCI. Ion abrasion scanning electron microscopy to view 3D EM images of HIV-infected cells. Resolution of about 20nm! Ive cell imaging tha...

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The Great Tragedy of Science | tragicscience.blogspot.com Reviews

https://tragicscience.blogspot.com

The Great Tragedy of Science. The slaying of a beautiful hypothesis by a single, ugly, fact. Tuesday, April 21, 2009. 3D architecture of the virological synapse and structural mechanisms of HIV entry - Sriram Subramaniam - National Institutes of Health. Sriram Subramaniam is head of the Biophysics Section of the Laboratory of Cell Biology and Senior Investigator at the NCI. Ion abrasion scanning electron microscopy to view 3D EM images of HIV-infected cells. Resolution of about 20nm! Ive cell imaging tha...

INTERNAL PAGES

tragicscience.blogspot.com

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The Great Tragedy of Science: Inhibition of retroviral infection by TRIMcyp and tetherin reveals a delicate balance between viral countermeasures and host restriction - Greg Towers - University College London

http://tragicscience.blogspot.com/2009/04/inhibition-of-retroviral-infection-by.html

The Great Tragedy of Science. The slaying of a beautiful hypothesis by a single, ugly, fact. Tuesday, April 21, 2009. Inhibition of retroviral infection by TRIMcyp and tetherin reveals a delicate balance between viral countermeasures and host restriction - Greg Towers - University College London. Greg Towers is professor of medical virology at the University College London and his research theme focuses on HIV tropism and antiviral innate immunity. How does Trim5 works? How did CypA get in the genome?

2

The Great Tragedy of Science: Dendritic cell factors required for HIV-1 infection - Allison Simmons - Weatherall Institute of Molecular Medicine

http://tragicscience.blogspot.com/2009/04/dendritic-cell-factors-required-for-hiv.html

The Great Tragedy of Science. The slaying of a beautiful hypothesis by a single, ugly, fact. Tuesday, April 21, 2009. Dendritic cell factors required for HIV-1 infection - Allison Simmons - Weatherall Institute of Molecular Medicine. DC-SIGN in the GALT. In the peyer's patch, DC-SIGN DCs are CXCR1 and CCR6 . Stimulation of DC-SIGN leads to signaling in DCs that does not require MyD88. HIV-1 binding leads to a similar signal transduction cascade compared to Ab. DC-SIGN stimulation overrides TLR4 signals.

3

The Great Tragedy of Science: Mechanisms of impaired gut mucosal defenses during HIV and SIV infections - Satya Dandekar - University of California at Davis

http://tragicscience.blogspot.com/2009/04/mechanisms-of-impaired-gut-mucosal.html

The Great Tragedy of Science. The slaying of a beautiful hypothesis by a single, ugly, fact. Tuesday, April 21, 2009. Mechanisms of impaired gut mucosal defenses during HIV and SIV infections - Satya Dandekar - University of California at Davis. Satya Dandekar is director of the developmental core of the Northern California Center for AIDS research of the University of California at Davis. SIV-induced loss of Th17 in GALT causes dissemination of S. typhimurium in SIV-infected rhesus macaques. 3D architec...

4

The Great Tragedy of Science: Mechanisms of Direct HIV Lymphocyte-to-Lymphocyte Transfer: role of "Polysynapses" - Olivier Schwartz - Institut Pasteur

http://tragicscience.blogspot.com/2009/04/mechanisms-of-direct-hiv-lymphocyte-to.html

The Great Tragedy of Science. The slaying of a beautiful hypothesis by a single, ugly, fact. Tuesday, April 21, 2009. Mechanisms of Direct HIV Lymphocyte-to-Lymphocyte Transfer: role of Polysynapses - Olivier Schwartz - Institut Pasteur. Polysynapses are representative of the diverse modes of HIV cell to cell transfer. Virological synapse with multiple contacts. Protrusions, filopodia, nanotube-like structures. HIV wt induce single, multiple and filopodia transfer. They also show that, not surprisingly, ...

5

The Great Tragedy of Science: Identification of HIV-specific IgG that inhibit infection of mucosal HIV target cells - Vincent Holl - Institute of Virology, France

http://tragicscience.blogspot.com/2009/04/identification-of-hiv-specific-igg-that_14.html

The Great Tragedy of Science. The slaying of a beautiful hypothesis by a single, ugly, fact. Tuesday, April 14, 2009. Identification of HIV-specific IgG that inhibit infection of mucosal HIV target cells - Vincent Holl - Institute of Virology, France. What antibody inhibit HIV infection of interstitial DCs and langherans cells as well as trans infection. Is HIV binding and capture different between interstitial DCs and LC? If you remove Fc portion, you get similar inhibition for LCs and intDC as PBMC.

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The Great Tragedy of Science

The Great Tragedy of Science. The slaying of a beautiful hypothesis by a single, ugly, fact. Tuesday, April 21, 2009. 3D architecture of the virological synapse and structural mechanisms of HIV entry - Sriram Subramaniam - National Institutes of Health. Sriram Subramaniam is head of the Biophysics Section of the Laboratory of Cell Biology and Senior Investigator at the NCI. Ion abrasion scanning electron microscopy to view 3D EM images of HIV-infected cells. Resolution of about 20nm! Ive cell imaging tha...

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