variationontology.org variationontology.org

variationontology.org

VariO

Variation Ontology, VariO. Is an ontology for standardized, systematic description of effects, consequences and mechanisms of variations. VariO. Allows unambiguous description of variation effects as well as computerized analyses over databases utilizing the ontology for annotation. VariO. Is a position specific ontology that can be used to describe effects of variations on DNA, RNA and/or protein level, whatever is appropriate. Annotation of variation effects. Comparison of variations and datasets.

http://www.variationontology.org/

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CONTACTS AT VARIATIONONTOLOGY.ORG

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Mauno Vihinen

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VariO | variationontology.org Reviews
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Variation Ontology, VariO. Is an ontology for standardized, systematic description of effects, consequences and mechanisms of variations. VariO. Allows unambiguous description of variation effects as well as computerized analyses over databases utilizing the ontology for annotation. VariO. Is a position specific ontology that can be used to describe effects of variations on DNA, RNA and/or protein level, whatever is appropriate. Annotation of variation effects. Comparison of variations and datasets.
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2 suggest a term
3 principles
4 annotation
5 variotator
6 amivario
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VariO | variationontology.org Reviews

https://variationontology.org

Variation Ontology, VariO. Is an ontology for standardized, systematic description of effects, consequences and mechanisms of variations. VariO. Allows unambiguous description of variation effects as well as computerized analyses over databases utilizing the ontology for annotation. VariO. Is a position specific ontology that can be used to describe effects of variations on DNA, RNA and/or protein level, whatever is appropriate. Annotation of variation effects. Comparison of variations and datasets.

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variationontology.org variationontology.org
1

VariO protein annotation examples

http://www.variationontology.org/annotation/protein_examples

VariO protein annotation examples. Examples of annotation of protein variation on type, function, structure and property level using the Variation Ontology VariO. All these examples are discussed in Vihinen, M., in press. Types and effects of protein variations. Protein Variation type annotation examples. Protein Variation function annotation examples. Protein Variation structure annotation examples.

2

AmiVariO: Tree Browser

http://www.variationontology.org/cgi-bin/amivario/browse.cgi

Last action: Reset the tree. VariO:0128 : variation affecting DNA. VariO:0002 : variation affecting protein. VariO:0297 : variation affecting RNA. VariO:0232 : variation attribute. AmiVariO version: 1.04. VariO database release 20:08:2015 09:01.

3

VariO

http://www.variationontology.org/VariOtator.php

VariO annotation tool VariOtator. Annotations from provided information. This page will help you to choose terms for annotating variation affecting type, function, structure and property. When generating VariO. You will also be asked to choose attribute terms and terms from the Evidence Ontology ECO. You can find a batch version of the tool (variation type annotation only) here. Is available for generation of client programs in many languages. New annotation will be added to previously annotation).

4

VariO - Instructions

http://www.variationontology.org/instructions.shtml

Suggest a term to VariO. Is intended to be a community wide standard for variation effect description and annotation. We welcome feedback and suggestions from the community to make improvements. We will constantly develop the ontology, and we are happy to receive suggestion on how to improve it. Like any ontology, VariO. Ontology can be viewed using an ontology editor, such as OBO-Edit. And downloaded in OBO, OWL and GO RDF-XML format. Please send feedback by e-mail. Like all biological ontologies, can n...

5

VariO - principles

http://www.variationontology.org/principles.shtml

VariO can be used for description of variations. Of whatever type (natural/engineered). With experimentally verified or predicted effect(s). Does not describe actual variation on nucleotide/protein level. Does not contain any clinical information. Is position specific. It can be used to explain whatever size of variation ranging from single nucleotide to entire genome. Explains the change caused by the variation, not the normal/wild type property, function etc.

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structure.bmc.lu.se structure.bmc.lu.se

Protein Structure and Bioinformatics Group

http://structure.bmc.lu.se/index.php

Protein Structure and Bioinformatics Group. The Protein Structure and Bioinformatics (LU PSB) develops methods and performs analyses to understand biological and medical phenomena at genetic, functional, mechanical and systems level. The group has two major research areas. One is related to collection, interpretation and distribution of information related to variations and their effects in multiple levels. The major development areas are. Studies of structural bases of diseases. Large scale data analysis.

gen2phen.org gen2phen.org

GEN2PHEN Resources | G2P Knowledge Centre

http://www.gen2phen.org/resources

Skip to main content. GEN2PHEN-sponsored software development projects. A central data 'clearinghouse' for streamlining the flow of single-locus variation data from clinical diagnostic laboratories to LSDBs. Can be redeployed to support the safe advertising of many types of data. http:/ www.cafevariome.org. Integration of genetic and medical information for health applications. http:/ www.diseasecard.org. Human Genome Mutation Database (HGMD). Human Splicing Finder (HSF). Systematic description of conseq...

structure.bmc.lu.se structure.bmc.lu.se

Protein Structure and Bioinformatics Group

http://structure.bmc.lu.se/services.php

Web site for proteomics studies of B cell differentiation. Http:/ structure.bmc.lu.se/BcellProteome/. Benchmark datasets available in bioinformatics. Collected by Lund University Protein Structure and Bioinformatics Group (LU PSB). Http:/ structure.bmc.lu.se/benchmark datasets/index.php. Http:/ structure.bmc.lu.se/ MultiDisp/index.html. Systematic classification of primary immunodeficiencies based on clinical, pathological and laboratory parameters. Http:/ structure.bmc.lu.se/PON-BTK/. Is a multifactoria...

structure.bmc.lu.se structure.bmc.lu.se

Protein Structure and Bioinformatics Group

http://structure.bmc.lu.se/databases.php

Are locus-specific databases for immunodeficiency-causing variations, which contain in addition to variation information also some clinical data. Http:/ structure.bmc.lu.se/idbase/. Is a comprehensive database of disease-causing variations in protein kinase domains. Http:/ structure.bmc.lu.se/idbase/KinMutBase/. Is a database for disease-causing variants in Src holology 2 (SH2) domains. Http:/ structure.bmc.lu.se/idbase/SH2base/. Http:/ structure.bmc.lu.se/idbase/IDRefSeq/idr/index.shtml. Guidelines for ...

varioml.org varioml.org

VarioML About

http://www.varioml.org/about.htm

Digging Deeper into Life:. How do I use VarioML? Nomenclature for Genomic Variation. UPDATE: The VarioML paper. Has been published - read it here. Standardising access to LSDB data helps researchers provide up-to-date information on sequence variation between individuals. This increases our understanding of the relationship between DNA variations and disease. VarioML is not 'Yet Another Data Standard', but instead a way to make sense of the different formats already used in the lab and clinic. There ...

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variationontology.org variationontology.org

VariO

Variation Ontology, VariO. Is an ontology for standardized, systematic description of effects, consequences and mechanisms of variations. VariO. Allows unambiguous description of variation effects as well as computerized analyses over databases utilizing the ontology for annotation. VariO. Is a position specific ontology that can be used to describe effects of variations on DNA, RNA and/or protein level, whatever is appropriate. Annotation of variation effects. Comparison of variations and datasets.

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