wiki.toxbank.net

Main Page - ToxBank Gold Compounds and Biological Materials Wiki

The following wiki pages provide information on compounds and biological materials developed as part of the SEURAT-1. Cluster through the ToxBank. Project. The research leading to these results has received funding from Cosmetics Europe. And the European Community’s Seventh Framework Programme. Gold compounds wiki pages. Questions, inquiries, comments and feedback regarding the scientific content. On these pages may be directed to the Gold Compound Working Group (GCWG). Of the ToxBank project. This wiki ...

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The following wiki pages provide information on compounds and biological materials developed as part of the SEURAT-1. Cluster through the ToxBank. Project. The research leading to these results has received funding from Cosmetics Europe. And the European Community’s Seventh Framework Programme. Gold compounds wiki pages. Questions, inquiries, comments and feedback regarding the scientific content. On these pages may be directed to the Gold Compound Working Group (GCWG). Of the ToxBank project. This wiki ...

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Main Page - ToxBank Gold Compounds and Biological Materials Wiki | wiki.toxbank.net Reviews

https://wiki.toxbank.net

The following wiki pages provide information on compounds and biological materials developed as part of the SEURAT-1. Cluster through the ToxBank. Project. The research leading to these results has received funding from Cosmetics Europe. And the European Community’s Seventh Framework Programme. Gold compounds wiki pages. Questions, inquiries, comments and feedback regarding the scientific content. On these pages may be directed to the Gold Compound Working Group (GCWG). Of the ToxBank project. This wiki ...

INTERNAL PAGES

wiki.toxbank.net

1

CCl4 - ToxBank Gold Compounds and Biological Materials Wiki

http://www.wiki.toxbank.net/wiki/CCl4

Carbon tetrachloride is oxidized to the trichloromethyl free radical, from which ensues alkylation of proteins and DNA along with lipid peroxidation. Depletion of ATP precedes acute cytotoxicity. Carcinogenicity is observed on long-term, low dose exposure. Gold Compound Working Group (GCWG). MOA standard for free radical generation. Recommended Product and Source. Hepatic and renal toxicity are due to biotransformation of CCl4 to toxic metabolites. In acute lethal CCl4 exposures, autopsy reveals mark...

2

Acetaminophen - ToxBank Gold Compounds and Biological Materials Wiki

http://www.wiki.toxbank.net/wiki/Acetaminophen

Metabolic oxidation to the quinone imine NAPQI metabolite, which traps cellular thiols, both protein and GSH, by formation of covalent adducts. Studies of quinone imine analogues suggest additional depletion of thiols by redox cycling. Acetaminophen is selected based on its chemical mechanism, which is representative of quinones with a high reduction potential. Gold Compound Working Group (GCWG). Recommended Product and Source. Acetaminophen is thought to act primarily in the CNS, increasing the pain thr...

3

User:Dbower - ToxBank Gold Compounds and Biological Materials Wiki

http://www.wiki.toxbank.net/wiki/User:Dbower

Retrieved from " http:/ www.wiki.toxbank.net/wiki/User:Dbower. David Bower . ChiPSC 2 / DEF-ChiPSC3. ChiPSC 3 / DEF-ChiPSC2. ChiPSC 4 / DEF-ChiPSC4. GIBCO Plateable Cryopreserved human hepatocytes. Human Recombinant BMP4 (PHC9534). Human Recombinant EGF (E9644). Human Recombinant EGF (G5021). Human Recombinant FGF Basic (233-FB-025). Human Recombinant FGF Basic (G5071). Human Recombinant FGF4 (PHG0154). Human Recombinant HGF (PHG0254). Human Recombinant Oncostatin M (PHC5015). Aluminum potassium sulfate...

4

Amiodarone - ToxBank Gold Compounds and Biological Materials Wiki

http://www.wiki.toxbank.net/wiki/Amiodarone

Steatosis, phospholipidosis, cytotoxicity. Amiodarone inhibits mitochondrial fatty oxidation and oxidative phosphorylation. As a cationic, amphiphilic drug, it also induces phospholipidosis. Toxicity does not require metabolic activation and is observed in multiple organs and cell types. Amiodarone was selected as a standard for promiscuous activities associated with membrane disruption. Gold Compound Working Group (GCWG). Beta blocker, K channel blocker. Recommended Product and Source. Amiodarone’s toxi...

5

Bosentan - ToxBank Gold Compounds and Biological Materials Wiki

http://www.wiki.toxbank.net/wiki/Bosentan

Competitive inhibition of the BSEP bile salt export pump. Toxicity is attributed to the parent drug, and there is no evidence for formation of reactive metabolites. Bosentan is selected to exemplify induction of cholestasis without accompanying chemical reactivity or other promiscuous activity. Gold Compound Working Group (GCWG). Recommended Product and Source. Tracleer (bosentan) full prescribing information. Actelion Pharmaceuticals US, Inc. February 2011. Bosentan-induced liver injury can be explained...

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toxbank.net

Biomaterials | ToxBank

http://www.toxbank.net/biomaterials

TODAY IS Monday, 05. September, 2016, 2:11 AM. REQUEST ACCESS TO DATA WAREHOUSE. Biological materials wiki pages. The ToxBank wiki pages. Provide information on compounds and biological materials developed as part of the SEURAT-1. Cluster through the ToxBank project. This wiki contains information on cells and reagents relevant to the SEURAT-1 cluster. The following documents provides guidance for the banking and supply of human embryonic stem cells:. Map of European suppliers. At the UK Stem Cell Bank.

toxbank.net

Compound and Biological Materials Wiki | ToxBank

http://www.toxbank.net/compound-wiki

TODAY IS Monday, 05. September, 2016, 2:11 AM. REQUEST ACCESS TO DATA WAREHOUSE. Compound and Biological Materials Wiki. Gold compounds wiki pages. The ToxBank wiki pages. Provide information on compounds and biological materials developed as part of the SEURAT-1. Cluster through the ToxBank project. Information on ToxBank wiki. Questions, inquiries, comments and feedback regarding the scientific content on these pages may be directed to the Gold Compound Working Group (GCWG).

toxbank.net

Biological Materials Wiki | ToxBank

http://www.toxbank.net/bio-wiki

TODAY IS Monday, 05. September, 2016, 2:11 AM. REQUEST ACCESS TO DATA WAREHOUSE. Biological materials wiki pages. The ToxBank wiki pages. Provide information on compounds and biological materials developed as part of the SEURAT-1. Cluster through the ToxBank project. This wiki contains information on cells and reagents relevant to the SEURAT-1 cluster. The following documents provide guidance for the banking and supply of human embryonic stem cells:. Map of European suppliers.

opentox.net

ToxBank Project | OpenTox

http://www.opentox.net/toxbank-project

TODAY IS Wednesday, August 31, 2016, 12:48 PM. Supporting integrated data analysis and servicing. Of alternative testing methods in toxicology. Establishes a dedicated web-based warehouse for toxicity data management and modelling, a "gold standards" compound database and repository of selected test compounds, and a reference resource for cells, cell lines and tissues of relevance for. Systemic toxicity research carried out across the FP7 HEALTH.2010.4.2.9. Alternative Testing Strategies SEURAT-1.

toxbank.net

ToxBank demo for WC9, Prague | ToxBank

http://www.toxbank.net/video/toxbank-demo-wc9

TODAY IS Monday, 05. September, 2016, 2:10 AM. REQUEST ACCESS TO DATA WAREHOUSE. The basics on Toxicogenomics. The Gold Compound methods. ToxBank Data Warehouse Overview. Search the Data Warehouse. Access to Biomaterial information. Upload an existing Investigation. Upload unformatted data (large). Upload unformatted data (small). Upload report or publication. Upload a methods summary. Creating a Transcriptomics Assay. Links and help resources. Downloading ISA tab data. Using data in other applications.

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wiki.toxbank.net

Main Page - ToxBank Gold Compounds and Biological Materials Wiki

The following wiki pages provide information on compounds and biological materials developed as part of the SEURAT-1. Cluster through the ToxBank. Project. The research leading to these results has received funding from Cosmetics Europe. And the European Community’s Seventh Framework Programme. Gold compounds wiki pages. Questions, inquiries, comments and feedback regarding the scientific content. On these pages may be directed to the Gold Compound Working Group (GCWG). Of the ToxBank project. This wiki ...

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