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HOMEApplication of structural biology and biophysical methods to develop novel reagents for basic and translational research.
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Application of structural biology and biophysical methods to develop novel reagents for basic and translational research.
http://www.williamslab.org/
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HOME | williamslab.org Reviews
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Application of structural biology and biophysical methods to develop novel reagents for basic and translational research.
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Publications
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Design and development of masked therapeutic antibodies to limit off-target effects: Application to anti-EGFR antibodies. Rodeck U and WIlliams JC (2009). Nature's design: A blueprint for engineered therapeutic antibodies. Enhanced EGFR inhibition and distinct epitope recognition by EGFR antagonistic mAbs C225 and 425. Development and application of in vivo molecular traps reveals that dynein light chain occupancy differentially affects dynein-mediated processes. Tan G et al (2007).
Lab Members
http://www.williamslab.org/page3/page3.html
Christine Lightcap (Fox Chase Cancer Center). Amrita Dawn (Thomas Jefferson Univ.).
Structures
http://www.williamslab.org/page1/page1.html
Dynein IC bound to LC8 and TcTex1. Pak1 peptide bound to LC8.
Projects
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Williams lab
The Williams lab is in the Department of Biological Statistics and Computational Biology. We are broadly interested in developing computational methods that leverage large scale genetic data and in applying existing methods to study human genetic history, evolution, and the genetic basis of human disease. See Research. For details on ongoing work in the lab. Apr 27, 2015 - Non-crossover gene conversion manuscript published. Feb 23, 2015 - Sloan Foundation Fellowship announced. Proudly powered by WordPress.
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Application of structural biology and biophysical methods to develop novel reagents for basic and translational research.
Williams Laboratory Homepage - Bart Williams - Williams Laboratory
Van Andel Research Institute. Van Andel Research Institute. Van Andel Education Institute. Please sign in first. Please simply create an account before buying/booking any courses. Create an account for free! Cell Signaling and Carcinogenesis. The Williams Laboratory is interested in understanding how alterations in the Wnt signaling pathway cause human disease. Wnt signaling is an evolutionarily conserved process that functions in the differentiation of most tissues within the body. J Bone Miner Res.
The Williams Laboratory - Home
2013 The Williams Laboratory. Boston Children's Hospital 300 Longwood Avenue, Karp Research Building, Room 08125 Boston, MA 02115.
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