www1.jcsg.org

The Joint Center for Structural Genomics (JCSG) Homepage

The JCSG Production Center for the Protein Structure Initiative. The JCSG has developed and integrated new technologies, covering the gene-to-structure process, that facilitate high-throughput structural biology. The JCSG has determined high- resolution structures of more than 1000 proteins; many are first structural representatives of uncharacterized protein families. TOPSAN, Wiki-based information and annotation portal - learn about protein structures solved by structural genomics centers.

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The Joint Center for Structural Genomics (JCSG) Homepage | www1.jcsg.org Reviews

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The JCSG Production Center for the Protein Structure Initiative. The JCSG has developed and integrated new technologies, covering the gene-to-structure process, that facilitate high-throughput structural biology. The JCSG has determined high- resolution structures of more than 1000 proteins; many are first structural representatives of uncharacterized protein families. TOPSAN, Wiki-based information and annotation portal - learn about protein structures solved by structural genomics centers.

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The Joint Center for Structural Genomics (JCSG) Homepage | www1.jcsg.org Reviews

https://www1.jcsg.org

The JCSG Production Center for the Protein Structure Initiative. The JCSG has developed and integrated new technologies, covering the gene-to-structure process, that facilitate high-throughput structural biology. The JCSG has determined high- resolution structures of more than 1000 proteins; many are first structural representatives of uncharacterized protein families. TOPSAN, Wiki-based information and annotation portal - learn about protein structures solved by structural genomics centers.

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www1.jcsg.org

1

JCSG Data Archives

http://www1.jcsg.org/datasets-info.shtml

JCSG Repository of Crystallographic Datasets. The Joint Center for Structural Genomics has created a unique repository of X-ray crystallographic datasets for the structures that it has solved and deposited in the Protein Data Bank. This archive contains the experimental data and analyses from the data collection, data reduction, phasing, density modification, model building and refinement of JCSG structures. It also. In most cases, phasing was carried out either by SeMet, MAD or Molecular Replacement.

2

JCSG Publications

http://www1.jcsg.org/prod/newscripts/publications.cgi

Methodological and Other Publications. Dlx5 homedomain/DNA complex; structure, binding and effect of mutations related to split-hand and foot malformation syndrome. Proudfoot A, Axelrod HL, Geralt M, Fletterick RJ, Yumoto F, Deacon AM, Elsliger MA, Wilson IA, Wthrich K, Serrano P. Journal of Molecular Biology. DOI: 10.1016/j.jmb.2016.01.023). NMR reveals structural rearrangements associated to substrate insertion in nucleotide-adding enzymes. Mohanty B, Geralt M, Wthrich K, Serrano P. DOI: 10.1128/mB...

3

Target List Selection

http://www1.jcsg.org/prod/newscripts/public_targets/structure.html

Click anywhere on bar below to display a new range. Report Date: Thu 23-Apr-2015 11:45:48. Predicted HD superfamily hydrolase. A zinc-binding protein from cupin superfamily involved in tetracenomycin polyketide synthesis. Putative General Stress Protein 26 with a PNP-Oxidase like fold. Haloacid delahogenase-like family hydrolase. Serine hydrolase (alpha/beta hydrolase) [DPP6 catalytic domain-like] with a conserved catalytic triad (S108/D186/H217). Protein of unknown function with cystatin-like fold.

4

Target List Selection

http://www1.jcsg.org/prod/newscripts/public_targets/pdb.html

Click anywhere on bar below to display a new range. Report Date: Thu 23-Apr-2015 11:45:52. Predicted HD superfamily hydrolase. A zinc-binding protein from cupin superfamily involved in tetracenomycin polyketide synthesis. Putative General Stress Protein 26 with a PNP-Oxidase like fold. Haloacid delahogenase-like family hydrolase. Serine hydrolase (alpha/beta hydrolase) [DPP6 catalytic domain-like] with a conserved catalytic triad (S108/D186/H217). Protein of unknown function with cystatin-like fold.

5

JCSG Target Search

http://www1.jcsg.org//prod/newscripts/jcsgblast/find_target.cgi

This service searches the homologs of protein sequences against JCSG Targets. The protein sequences must be in FASTA format (uncompressed or compressed). The number of sequences must be less than or equal to 50. The JCSG is supported by the NIGMS, Protein Structure Initiative.

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The Joint Center for Structural Genomics (JCSG) Homepage

The JCSG Production Center for the Protein Structure Initiative. The JCSG has developed and integrated new technologies, covering the gene-to-structure process, that facilitate high-throughput structural biology. The JCSG has determined high- resolution structures of more than 1000 proteins; many are first structural representatives of uncharacterized protein families. TOPSAN, Wiki-based information and annotation portal - learn about protein structures solved by structural genomics centers.

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