xcovery.com
Xcovery | Targeted Therapy for ALK-Positive Lung CancerClinical-stage company developing next-generation targeted therapeutics for cancer. We've developed oncology therapy pipelines for advanced tumors.
http://www.xcovery.com/
Clinical-stage company developing next-generation targeted therapeutics for cancer. We've developed oncology therapy pipelines for advanced tumors.
http://www.xcovery.com/
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Xcovery | Targeted Therapy for ALK-Positive Lung Cancer | xcovery.com Reviews
https://xcovery.com
Clinical-stage company developing next-generation targeted therapeutics for cancer. We've developed oncology therapy pipelines for advanced tumors.
xcovery.com
News & Events | XCOVERY
http://www.xcovery.com/news-events
Clinical Trials Now Recruiting. EXalt 2 Clinical Trial. EXalt 3 Clinical Trial. News & Events. See what we're up to. News & Events. Xcovery Announces Initiation of Phase 3 Trial of X-396 in ALK Non-Small Cell Lung Cancer. June 29, 2016. Xcovery Presents Results of Plasma Genotyping of Patients in the eXalt2 Study at the ASCO Annual Meeting 2016. June 5, 2016. Xcovery to Present at the ASCO Annual Meeting 2016. June 1, 2016. April 20, 2016. Xcovery to Present at the AACR Annual Meeting 2016. April 12, 2016.
Publications | XCOVERY
http://www.xcovery.com/our-science/data-and-publications
Clinical Trials Now Recruiting. EXalt 2 Clinical Trial. EXalt 3 Clinical Trial. News & Events. Increase potency and reduce toxicity. ALK Poster Presented at ASCO 2014. ALK Poster Presented at Thoracic Symposium 2014.
PI3K/mTor | XCOVERY
http://www.xcovery.com/our-science/pi3k-mtor
Clinical Trials Now Recruiting. EXalt 2 Clinical Trial. EXalt 3 Clinical Trial. News & Events. Increase potency and reduce toxicity. Dual mTOR and PI3K Inhibitor X-480. Able to induce tumor regression as a single agent. Similar potency against PI3K and mTOR.
ALK Inhibitor | XCOVERY
http://www.xcovery.com/our-science/alk-inhibitor
Clinical Trials Now Recruiting. EXalt 2 Clinical Trial. EXalt 3 Clinical Trial. News & Events. Improve Tolerability, Increase Potency. ALK is deregulated by multiple mechanisms including translocation to form a constitutively active fusion protein, activating mutations in the kinase and gene amplification. The EML4-ALK fusion protein is found in a subpopulation of non-smokers that develop NSCLC. Multiple fusion proteins other than EML4-ALK have been identified in patients with ALCL. Similarly...Is a pote...
MET | XCOVERY
http://www.xcovery.com/our-science/met
Clinical Trials Now Recruiting. EXalt 2 Clinical Trial. EXalt 3 Clinical Trial. News & Events. Increase potency and reduce toxicity. X-379 Selective MET Inhibitor. Our Chinese partner AnewPharma has filed an investigational new drug (IND) application in China. Potent against all 8 clinically relevant mutants. Safety window allows for complete inhibition of c-Met.
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Xcovery blog - kinase industry knowledge collected and sometimes analyzed: Tarceva: running in place?
http://xcovery.blogspot.com/2007/01/tarceva-running-in-place.html
Xcovery blog - kinase industry knowledge collected and sometimes analyzed. Wednesday, January 24, 2007. Tarceva: running in place? One other note from the DNA earnings numbers: Tarceva sales grew 27% year over year and 7% sequentially (total: $107M). Very bad news for OSI. DNA is more motivated to push Avastin for solid tumors, so Tarceva is probably undermarketed by something between $500M and $1B. Subscribe to: Post Comments (Atom). Kinase Industry Biz News. Guide to biotech IP. IHOP - great protein db.
News & Events | Lung Cancer Research Council
http://lungcancerresearchcouncil.org/events
NEWS & EVENTS. RUN / WALK EVENTS. SUPPORT & RESOURCES. Patients & Caregivers. Celebrate Life Summer Social Honors Cancer Survivorship, Raises Nearly $8,500 for Lung Cancer Research Council. Thomas Cappiello, Yoko Cappiello, Jennifer Sexton, Christopher Sexton, Lynda Platt, Abby Ellner and Kim McCarren. Cancer survivors, supporters, friends and families recently came together at the Celebrate Life Summer Social in Punta Gorda to enjoy an evening . Lung Cancer Hope Month Survival Story.
Xcovery blog - kinase industry knowledge collected and sometimes analyzed: A couple of extra thoughts from 2006
http://xcovery.blogspot.com/2007/02/couple-of-extra-thoughts-from-2006.html
Xcovery blog - kinase industry knowledge collected and sometimes analyzed. Thursday, February 22, 2007. A couple of extra thoughts from 2006. Anybody else surprised that Iressa racked up nearly a quarter billion in revenue? I thought AZ was just maintaining Iressa in the hopes that biomarker/personalized medicine research would fully characterize responders with significant sales to come only after conclusive studies, but Iressa is still achieving good levels of revenue. And actual sales (? Welcome to ou...
Xcovery blog - kinase industry knowledge collected and sometimes analyzed: Why drugs fall short in late-stage trials
http://xcovery.blogspot.com/2007/01/why-drugs-fall-short-in-late-stage.html
Xcovery blog - kinase industry knowledge collected and sometimes analyzed. Wednesday, January 24, 2007. Why drugs fall short in late-stage trials. Kick-ass article from McKinsey reviewing why drugs fail in P3, based on 650 small molecule trials since 1990. Over all diseases, 42% of leads failed P3, slightly worse than most models anticipate. (The Milken Model. Anticipates a 33% failure rate at this stage for small molecules.). Quantitative endpoints (biomarkers) improve the likelihood of P3 success.
Xcovery blog - kinase industry knowledge collected and sometimes analyzed: Sutent now a first line therapy for RCC in Europe
http://xcovery.blogspot.com/2007/01/sutent-now-first-line-therapy-for-rcc.html
Xcovery blog - kinase industry knowledge collected and sometimes analyzed. Thursday, January 18, 2007. Sutent now a first line therapy for RCC in Europe. I found some information about SUTENT. Subscribe to: Post Comments (Atom). Kinase Industry Biz News. Guide to biotech IP. IHOP - great protein db. Seeking Alpha - solid biotech investment insight. Decent but dated summary of kinase therapeutics. Org Prep Daily (home of Milkshake). Whistling in the Wind. Kinase efforts you may not know of.
Xcovery blog - kinase industry knowledge collected and sometimes analyzed: Way cool kinase target popularity charts
http://xcovery.blogspot.com/2007/01/way-cool-kinase-target-popularity.html
Xcovery blog - kinase industry knowledge collected and sometimes analyzed. Wednesday, January 24, 2007. Way cool kinase target popularity charts. The Kinase Research Portal. Has a cool application (linked in the header to this post) that shows kinase publication history and allows you to see target-specific publication trend graphs. Here's an example showing p38 publication trends (with a surprisingly steep upward trajectory.). Subscribe to: Post Comments (Atom). Kinase Industry Biz News.
Xcovery blog - kinase industry knowledge collected and sometimes analyzed: Top 100 2006 Publications
http://xcovery.blogspot.com/2007/01/top-100-2006-publications.html
Xcovery blog - kinase industry knowledge collected and sometimes analyzed. Wednesday, January 24, 2007. Top 100 2006 Publications. The Kinase Research Portal. Has compiled what they consider the 100 best/most popular articles of the last year. The list (via the linked header for this post) is could be used as means of taking the pulse of kinase research. Gene target interest is very broad. I counted at least 25 different gene targets as article themes. Subscribe to: Post Comments (Atom). Interesting stor...
Xcovery blog - kinase industry knowledge collected and sometimes analyzed: 2006 kinase drug performance
http://xcovery.blogspot.com/2007/02/2006-kinase-drug-performance.html
Xcovery blog - kinase industry knowledge collected and sometimes analyzed. Wednesday, February 21, 2007. 2006 kinase drug performance. With the release of OSI's 4Q and year-end. Financial statements, the sales results for all 12 kinase-targeting drugs are finally available for the year 2006. And what a year it was. All told, we might see KDs contributing nearing $15B in annual sales in '07, with greater growth still to come. Nice table - thanks. Subscribe to: Post Comments (Atom). Kinase Industry Biz News.
Xcovery blog - kinase industry knowledge collected and sometimes analyzed: Miscellany
http://xcovery.blogspot.com/2007/02/miscellany.html
Xcovery blog - kinase industry knowledge collected and sometimes analyzed. Saturday, February 03, 2007. With an assist from In the Pipeline. Thinks BMS and Sanofi shouldn't pair up. I'm really surprised that more people haven't looked at the historical performance of pharma M and A - it's overwhelmingly not pretty. Somewhat related, Forbes. Subscribe to: Post Comments (Atom). Kinase Industry Biz News. Guide to biotech IP. IHOP - great protein db. Seeking Alpha - solid biotech investment insight.
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Xcovery blog - kinase industry knowledge collected and sometimes analyzed
Xcovery blog - kinase industry knowledge collected and sometimes analyzed. Tuesday, March 27, 2012. I've taken up blogging on bio-business over at Molecular Future. I continue some of my Xcovery-orginiated analysis and themes from 5 years ago. Protein kinases, drug development), and have expanded to include DNA sequencing, molecular diagnostics, economic development, PGX, and other fun topics. I can also be contacted through the new site tim -at- molecularfuture.com. Please stop by Molecular Future.
Xcovery | Targeted Therapy for ALK-Positive Lung Cancer
Clinical Trials Now Recruiting. News & Events. Targeted Therapy for ALK-Positive Lung Cancer Patients. NON-SMALL CELL LUNG CANCER. There are 9,000 new cases each year in the U.S. X-396 is being studied for patients with ALK-positive non-small-cell lung cancer. Suggested resources for patients with lung cancer and their families.
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