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Xenobe Research InstituteNo description found
http://www.xenobe.org/
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Xenobe Research Institute
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Xenobe Research Institute | xenobe.org Reviews
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Xenobe Research Institute
http://www.xenobe.org/phorboxazole.html
In 1995, Searle and Molinski reported the isolation and heroic structure elucidation of phorboxazole A and B from the marine sponge. Subsequent isolation efforts by Capon validated that observation ( read it now. Over a decade after its isolation, synthetic efforts from the laboratories of Burke ( read it now. Evans ( read it now. Forsyth (read it now. Smith ( read it now. Pattenden ( read it now. Panek ( read it now. Rychnovsky ( read it now. Williams ( read it now. And White ( read it now.
Xenobe Research Institute
http://www.xenobe.org/bielschowskysin.html
Bielschowskysin is a naturally occurring diterpene isolated from the Caribbean gorgonian octocoral. By a team led by Rodríguez and Capson ( read it now. Collaborative studies with the Rodríguez (University of Puerto Rico). And Lear (National University of Singapore). Laboratories are now underway to probe its modes of action in tumor cells. We are also exploring how this unique natural product inhibits the growth of the malaria parasite.
Xenobe Research Institute
http://www.xenobe.org/laetirobin.html
Isolation efforts launched in 2006 have identified a novel natural product from specimens of. Our studies were appeared in late 2009 in the Journal of Natural Products ( read it now. These materials are now being used to probe the mechanism(s) in which ( /-)-laetirobin alters cell division and blocks tumor cell growth.
Xenobe Research Institute
http://www.xenobe.org/trichodermamides.html
Trichodermamides, are a family of modified dipeptides, isolated from cultures of the marine-derived fungus. Reported in 2003 by Clardy, Fenical and Jensen. The trichodermamides possess a rare cyclic O-alkyl-oxime functionality incorporated into a six-membered ring. Synthesis of the more active, trichodermamide B, was recently completed in the Zakarian laboraory ( read it here. And Joullie laboratory (read it here.
Xenobe Research Institute
http://www.xenobe.org/ammosamides.html
We have completed studies on a new family of pyrroloquinolines, the ammosamides A and B, in collaboration with the Fenical laboratory at the Scripps Insitution of Oceanography ( structures published here. Using an immunofluorescence affinity (IAF) strategy, Chambers Hughes in the Fenical laboratory prepared an analog of ammosamide B that was used for both cellular microscopy and protein target indentification studies at XRI to identify myosin as a target of the ammosamides ( read it here.
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NPAG - Natural Products Affinity Group
http://npag.ucsd.edu/mission.html
The past decade has witnessed a remarkable concentration of natural product research in the La Jolla and greater San Diego area. Our current participants include:. Burkart Laboratory at the Department of Chemistry and Biochemistry of UC San Diego. Dorrestein Laboratory at the Skaggs School of Pharmacy and Pharmaceutical Sciences of UC San Diego. Fenical Laboratory at Scripps Institution of Oceanography. Hughes Laboratory at Scripps Institution of Oceanography. Finally - NPAG would not be possible without...
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Xenobe Research Institute
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Xenobe Purvis - Novelist and writer based in London
Novelist and writer based in London.
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