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Junying Yuan was inspired by a face-to-face encounter with a patient of Huntington’s disease as a young graduate student in early 1980s to explore the mechanism of neurodegeneration at a time when very few would contemplate the idea that cells might commit suicide. Although she was a Ph.D. student at the Harvard Medical School at that time, she convinced the program director to allow her to work in the laboratory of H. Robert Horvitz. As a part of her Ph.D. thesis work, Yuan demonstrated that.

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Junying Yuan was inspired by a face-to-face encounter with a patient of Huntington’s disease as a young graduate student in early 1980s to explore the mechanism of neurodegeneration at a time when very few would contemplate the idea that cells might commit suicide. Although she was a Ph.D. student at the Harvard Medical School at that time, she convinced the program director to allow her to work in the laboratory of H. Robert Horvitz. As a part of her Ph.D. thesis work, Yuan demonstrated that.

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Home | Yuan Lab | yuan.med.harvard.edu Reviews

https://yuan.med.harvard.edu

Junying Yuan was inspired by a face-to-face encounter with a patient of Huntington’s disease as a young graduate student in early 1980s to explore the mechanism of neurodegeneration at a time when very few would contemplate the idea that cells might commit suicide. Although she was a Ph.D. student at the Harvard Medical School at that time, she convinced the program director to allow her to work in the laboratory of H. Robert Horvitz. As a part of her Ph.D. thesis work, Yuan demonstrated that.

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yuan.med.harvard.edu

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Reagent Requests | Yuan Lab

https://yuan.med.harvard.edu/reagent_requests

Thank you very much for your interest in our research. We make all of our published reagents available for your research. Here is some information to help you to locate specific reagents that might be of interest to you:. Many of our published plasmids have been provided to Addgene. Please search this website to see if you can find what you want ( http:/ www.addgene.org. Many of our published antibodies are commercially available. The cyclophilin A antibody used in Christofferson et al.

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Home | Yuan Lab

https://yuan.med.harvard.edu/home

Junying Yuan made critical contributions to our understanding of apoptosis and necroptosis, two fundamental mechanisms that regulate the survival and death of mammalian cells. Her Ph.D. work, as a student at the Harvard Medical School and conducted in the laboratory of H. Robert Horvitz. At the Massachusetts Institute of Technology, provided the first insight into the mechanism of programmed cell death in the nematode. Cell death gene product Ced-3 ( Miura et al. 1993. Degterev et al. 2008. This discover...

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CV | Yuan Lab

https://yuan.med.harvard.edu/cv

Department of Cell Biology. Boston, MA 02115. 1982 BS in Biochemistry. Fudan University, Shanghai, China. 1989 Ph.D. in Neuroscience. Harvard University (Neuroscience). Advisor: H. Robert Horvitz. 1990-1993 Instructor of Medicine, Harvard Medical School. 1990-1996 Assistant Geneticist, Massachusetts General Hospital, Cardiovascular Research Center. 1993-1996 Assistant Professor of Medicine, Harvard Medical School. 1996-1997 Assistant Professor of Cell Biology, Harvard Medical School. 1999-present Member ...

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Research in Yuan Lab | Yuan Lab

https://yuan.med.harvard.edu/discoveries

Research in Yuan Lab. The research of Professor Yuan focuses on the molecular mechanisms that regulate cell death. Regulation of cell death is critical for human health. Defects in the cell death mechanisms play critical roles in the etiology of major human diseases such as cancer. Over the past two decades, the research in Yuan lab has provided major insights into the molecular mechanisms that control multiple forms of regulated cell death, including apoptosis. As a critical signal.

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Publications | Yuan Lab

https://yuan.med.harvard.edu/selected_publications

All publications from Yuan Lab ( Google Scholar link. Phosphorylation and activation of ubiquitin-specific protease-14 by Akt regulates the ubiquitin-proteasome system. Xu D, Shan B, Lee BH, Zhu K, Zhang T, Sun H, Liu M, Shi L, Liang W, Qian L, Xiao J, Wang L, Pan L, Finley D, Yuan J. Elife. Pharmacologic agents targeting autophagy. Vakifahmetoglu-Norberg H, Xia HG, Yuan J. J Clin Invest. Activation of necroptosis in multiple sclerosis. 2015 Mar 24;10(11):1836-49. 2015 Aug 31;210(5):705-16. Xiao J, Zhang...

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Home | Yuan Lab

Junying Yuan was inspired by a face-to-face encounter with a patient of Huntington’s disease as a young graduate student in early 1980s to explore the mechanism of neurodegeneration at a time when very few would contemplate the idea that cells might commit suicide. Although she was a Ph.D. student at the Harvard Medical School at that time, she convinced the program director to allow her to work in the laboratory of H. Robert Horvitz. As a part of her Ph.D. thesis work, Yuan demonstrated that.

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