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CANDOR simulation − Mathematical modelling matters!Consultancy and development based on extensive experience in computer simulation and mathematical model building of real-world problems
http://www.candorsim.dk/
Consultancy and development based on extensive experience in computer simulation and mathematical model building of real-world problems
http://www.candorsim.dk/
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CANDOR simulation − Mathematical modelling matters! | candorsim.dk Reviews
https://candorsim.dk
Consultancy and development based on extensive experience in computer simulation and mathematical model building of real-world problems
PKPDsim – Mathematical modelling of antibiotics PK/PD
As one of its core activities, CANDOR simulation. Offers expert consultancy in. Mathematical PK/PD modelling to support critical decisions in drug development. And usage with focus on antibiotics. We can support the client on a range of PK/PD-oriented tasks, such as:. Optimal design of experimental studies (. Noncompartmental analysis; check for nonlinear or time-dependent. Compartmental analysis: Semiphysiological modelling. Estimation of population model parameter distributions. PTA) and MIC breakpoints.
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Services | CANDOR simulation
http://www.candorsim.dk/service.html
Mathematical modelling and complex systems analysis. To bring the projects ahead. CANDOR simulation offers consultancy and problem. Solving based on extensive experience in building valid. Mathematical models of real-world problems; performing a thorough. Model analysis, − and finally using the gained insight on the original problem. The toolbox comprises a series of techniques, in particular for studying dynamical systems, including. Minus; nonlinear analysis of time series. Minus; Monte Carlo simulation.
CANDOR simulation − Matematisk modellering der nytter!
http://www.candorsim.dk/index-da.html
Matematisk modellering og analyse af komplekse systemer. Holdbare analyser . . .
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Ciprofloxacin PK/PD in experimental UTI
http://www.pkpdsim.candorsim.dk/p-ICAAC2012.html
MIC, AUC/MIC " /. Poster at ICAAC 2012:. L Jakobsen, K.S. Jensen, C.V. Lundberg, N. Frimodt-Møller. Ciprofloxacin (CIP) PK/PD in Experimental Urinary Tract Infection (UTI) Depends on Time MIC and not AUC24/MIC. Ciprofloxacin is widely used to treat UTI although resistance is increasing. The AUC/MIC ratio is considered the most important PK/PD index for effect, but whether this accounts for treatment of UTI has not been studied in detail.
Estimation of MIC breakpoints for mecillinam iv dosage
http://www.pkpdsim.candorsim.dk/p-ECCMID2009.html
Poster at ECCMID 2009:. K Skovbo Jensen, A. Santerre Henriksen, N. Frimodt-Møller. Estimation of MIC breakpoints for intravenous dosage regimens of mecillinam. Population PK model parameters, nonparametric distribution, probability of target attainment (PTA), PKPDsim.
Estimation of adequate pivmecillinam dosage for E. coli
http://www.pkpdsim.candorsim.dk/p-ECCMID2008.html
Poster at ECCMID 2008:. KS Jensen, A.S. Henriksen, N. Frimodt-Møller. Pivmecillinam: Estimation of adequate dosage for susceptible and ESBL-producing E. coli by Monte Carlo PK/PD simulation. Pharmacokinetic data for mecillinam concentrations after per oral dosing of 400 mg pivmecillinam: 11 measurements of serum concentration within 8 hours from intake were recorded in 17 healthy volunteers. Breakpoints, population PK model parameters, probability of target attainment.
Monte Carlo simulation of isoniazid PK/PD in patients
http://www.pkpdsim.candorsim.dk/p-ICAAC2013.html
Poster at ICAAC 2013:. JB Prahl, K.S. Jensen, N. Seersholm, T. Wilcke, Å.B. Andersen, N. Frimodt-Møller. PK/PD with Monte Carlo simulation of isoniazid in tuberculosis patients. The present study reports the results of a Monte Carlo simulation based PK/PD analysis of INH in TB patients receiving standard TB treatment of INH, rifampicin, ethambutol and pyrazinamide once daily. The PK/PD analysis was performed to determine probability of target attainment for AUC24/MIC = 500 h. Population model, PTA.
Software | PKPDsim
http://www.pkpdsim.candorsim.dk/software.html
The PKPDsim software package. The software covers a broad range of topics related to pharmacokinetics and. Pharmacodynamics (PK/PD) of antibiotics in particular; from estimation of drug. Concentrations from zone diameters in a bio assay to simulation assisted design. Of experimental studies, e.g. optimum selection of dosage regimens for. The PKPDsim package consists of a number of programs:. Estimates drug concentrations from measured zone. The results can be used as input for the initESTIM program.
Comparison of pivampicillin dosage regimens
http://www.pkpdsim.candorsim.dk/p-ECCMID2007.html
Poster at ECCMID 2007:. K Skovbo Jensen and N. Frimodt-Møller. Comparison of oral dosage regimens for pivampicillin by Monte Carlo PK/PD simulation. The simulations indicate that for streptococcal infections (MIC≤0.063 mg/L), the total daily dose can be reduced to less than 40% if the intake is distributed on three instead of two occations per day. Streptococcus pneumoniae, S. pyogenes, population PK model parameters, probability of target attainment (PTA), oral dosage.
PK/PD of dicloxacillin and linezolid against S. aureus in vivo
http://www.pkpdsim.candorsim.dk/p-ICAAC2007.html
Poster at ICAAC 2007:. A Sandberg, K.S. Jensen, R.L. Skov, N. Frimodt-Møller. PK/PD of Dicloxacillin (D) and Linezolid (L) against S. aureus Intra (IC)- and Extracellularly (EC) in vivo: Early drug exposure (Time MIC for 1. dose) is crucial for effect. Compartment model, T MIC, population PK-parameters, Monte Carlo simulation.
Probability of target attainment for cefuroxime dosage
http://www.pkpdsim.candorsim.dk/p-ICAAC2011.html
Poster at ICAAC 2011:. KS Jensen, N.B. Nielsen, M. Skjønnemand, D.S. Hansen, K.H.W. Lange, N. Frimodt-Møller. Probability of Target Attainment for Cefuroxime (CXM) Dosage Against Some Common Bacteria. S aureus, E. coli, Klebsiella pneumoniae, Streptococcus pneumoniae, population modeling, Monte Carlo simulation, MIC distributions.
PK/PD of mecillinam in a murine UTI model
http://www.pkpdsim.candorsim.dk/p-ICAAC2009.html
MIC, urine, bladder, kidney, E. coli, ESBL " /. Poster at ICAAC 2009:. C Vingsbo Lundberg, P. Kvist, K. Kemp, K.S. Jensen, N. Frimodt-Møller. In vivo PK/PD of mecillinam in a murine urinary tract infection (UTI) model. Mecillinam is a promising drug for treatment of urinary tract infection (UTI) caused by ESBL-producing E. coli. We used a UTI model in mice to identify the PK/PD index that best correlates with efficacy of mecillinam. Predictive PK/PD index, T MIC, PKPDsim, urine, bladder, kidney.
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CANDOR simulation − Mathematical modelling matters!
Mathematical modelling and complex systems analysis. Reliable analyses . . .
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