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PKPDsim   –   Mathematical modelling of antibiotics PK/PD

CANDOR simulation offers expert consultancy on mathematical modelling and analyses of antibiotics pharmacometrics using the PKPDsim software

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PKPDsim   –   Mathematical modelling of antibiotics PK/PD | pkpdsim.candorsim.dk Reviews
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CANDOR simulation offers expert consultancy on mathematical modelling and analyses of antibiotics pharmacometrics using the PKPDsim software
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6 pharmacokinetics
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PKPDsim   –   Mathematical modelling of antibiotics PK/PD | pkpdsim.candorsim.dk Reviews

https://pkpdsim.candorsim.dk

CANDOR simulation offers expert consultancy on mathematical modelling and analyses of antibiotics pharmacometrics using the PKPDsim software

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1

Ciprofloxacin PK/PD in experimental UTI

http://www.pkpdsim.candorsim.dk/p-ICAAC2012.html

MIC, AUC/MIC " /. Poster at ICAAC 2012:. L Jakobsen, K.S. Jensen, C.V. Lundberg, N. Frimodt-Møller. Ciprofloxacin (CIP) PK/PD in Experimental Urinary Tract Infection (UTI) Depends on Time MIC and not AUC24/MIC. Ciprofloxacin is widely used to treat UTI although resistance is increasing. The AUC/MIC ratio is considered the most important PK/PD index for effect, but whether this accounts for treatment of UTI has not been studied in detail.

2

Estimation of MIC breakpoints for mecillinam iv dosage

http://www.pkpdsim.candorsim.dk/p-ECCMID2009.html

Poster at ECCMID 2009:. K Skovbo Jensen, A. Santerre Henriksen, N. Frimodt-Møller. Estimation of MIC breakpoints for intravenous dosage regimens of mecillinam. Population PK model parameters, nonparametric distribution, probability of target attainment (PTA), PKPDsim.

3

Estimation of adequate pivmecillinam dosage for E. coli

http://www.pkpdsim.candorsim.dk/p-ECCMID2008.html

Poster at ECCMID 2008:. KS Jensen, A.S. Henriksen, N. Frimodt-Møller. Pivmecillinam: Estimation of adequate dosage for susceptible and ESBL-producing E. coli by Monte Carlo PK/PD simulation. Pharmacokinetic data for mecillinam concentrations after per oral dosing of 400 mg pivmecillinam: 11 measurements of serum concentration within 8 hours from intake were recorded in 17 healthy volunteers. Breakpoints, population PK model parameters, probability of target attainment.

4

Monte Carlo simulation of isoniazid PK/PD in patients

http://www.pkpdsim.candorsim.dk/p-ICAAC2013.html

Poster at ICAAC 2013:. JB Prahl, K.S. Jensen, N. Seersholm, T. Wilcke, Å.B. Andersen, N. Frimodt-Møller. PK/PD with Monte Carlo simulation of isoniazid in tuberculosis patients. The present study reports the results of a Monte Carlo simulation based PK/PD analysis of INH in TB patients receiving standard TB treatment of INH, rifampicin, ethambutol and pyrazinamide once daily. The PK/PD analysis was performed to determine probability of target attainment for AUC24/MIC = 500 h. Population model, PTA.

5

Software | PKPDsim

http://www.pkpdsim.candorsim.dk/software.html

The PKPDsim software package. The software covers a broad range of topics related to pharmacokinetics and. Pharmacodynamics (PK/PD) of antibiotics in particular; from estimation of drug. Concentrations from zone diameters in a bio assay to simulation assisted design. Of experimental studies, e.g. optimum selection of dosage regimens for. The PKPDsim package consists of a number of programs:. Estimates drug concentrations from measured zone. The results can be used as input for the initESTIM program.

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Services | CANDOR simulation

http://www.candorsim.dk/service.html

Mathematical modelling and complex systems analysis. To bring the projects ahead. CANDOR simulation offers consultancy and problem. Solving based on extensive experience in building valid. Mathematical models of real-world problems; performing a thorough. Model analysis, − and finally using the gained insight on the original problem. The toolbox comprises a series of techniques, in particular for studying dynamical systems, including. Minus; nonlinear analysis of time series. Minus; Monte Carlo simulation.

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CANDOR simulation   −   Matematisk modellering der nytter!

http://www.candorsim.dk/index-da.html

Matematisk modellering og analyse af komplekse systemer. Holdbare analyser . . .

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PKPDsim   –   Mathematical modelling of antibiotics PK/PD

As one of its core activities, CANDOR simulation. Offers expert consultancy in. Mathematical PK/PD modelling to support critical decisions in drug development. And usage with focus on antibiotics. We can support the client on a range of PK/PD-oriented tasks, such as:. Optimal design of experimental studies (. Noncompartmental analysis; check for nonlinear or time-dependent. Compartmental analysis: Semiphysiological modelling. Estimation of population model parameter distributions. PTA) and MIC breakpoints.

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