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niaIDEAlist's Report

Microbiome and research reproducibility. June 11, 2016. This week journal Nature published a long overdue perspective where the authors argued that one of the critical, but frequently unaccounted reasons for pre-clinical research irreproducibility, was role of microbiome in shaping physiology and phenotype of laboratory animals. I am going to highlight some of the important messages from this article. Another important recommendation, the authors say, would be to conduct key experiments “in multipl...

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niaIDEAlist's Report | davidusharauli.wordpress.com Reviews

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Microbiome and research reproducibility. June 11, 2016. This week journal Nature published a long overdue perspective where the authors argued that one of the critical, but frequently unaccounted reasons for pre-clinical research irreproducibility, was role of microbiome in shaping physiology and phenotype of laboratory animals. I am going to highlight some of the important messages from this article. Another important recommendation, the authors say, would be to conduct key experiments “in multipl...

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niaIDEAlist's Report | davidusharauli.wordpress.com Reviews

https://davidusharauli.wordpress.com

Microbiome and research reproducibility. June 11, 2016. This week journal Nature published a long overdue perspective where the authors argued that one of the critical, but frequently unaccounted reasons for pre-clinical research irreproducibility, was role of microbiome in shaping physiology and phenotype of laboratory animals. I am going to highlight some of the important messages from this article. Another important recommendation, the authors say, would be to conduct key experiments “in multipl...

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davidusharauli.wordpress.com

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How I stumbled upon selfies back in 2004 | niaIDEAlist's Report

https://davidusharauli.wordpress.com/2015/11/01/how-i-have-stumbled-upon-my-selfies-back-in-2004

How I stumbled upon selfies back in 2004. November 1, 2015. Sometimes social culture changes and something becomes acceptable so rapidly that it’s just remarkable. I experienced at least one such event in 2004. But there was one problem. I wanted to send my photos to my family back in Georgia, showing my “life” at the workplace or at home. But how could I do it? However, within a few years the selfie concept became so mainstream that no one would now question a photo where someone is pictured alone. ...

2

My path to vegetarianism | niaIDEAlist's Report

https://davidusharauli.wordpress.com/2015/12/12/my-path-to-vegetarianism

My path to vegetarianism. December 12, 2015. It is now almost 8 months since I became a vegetarian 🍅 🍆🍴. This transformation did not happen overnight or even in 1 year. In fact, it took me 11 years to convert this idea of being a vegetarian into practice. From my point of view, there are few criteria (that should be met) that would allow for one’s transition from eating meat 🍗 to mostly plant diet [and some animal-derived diet, such as unfertilized eggs]. Out of these 3 criteria, #3. Unfertilized egg...

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Me on Twitter 1 year later | niaIDEAlist's Report

https://davidusharauli.wordpress.com/2016/02/15/me-on-twitter-1-year-later

Me on Twitter 1 year later. February 15, 2016. I joined Twitter a little over 1 year ago. Prior to this I was only on Blogger where I used to write my analysis of new research articles, specifically in immunology. Two reasons why I choose Twitter as my primary social site:. B) I have a quick mind and it is quite easy for me to come up with quick and short titles (at least I believe such things about me). So I thought Twitter can be a good venue to express my thoughts as “idea bursts”. Basically it was a ...

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dusharauli | niaIDEAlist's Report

https://davidusharauli.wordpress.com/author/dusharauli

Microbiome and research reproducibility. June 11, 2016. This week journal Nature published a long overdue perspective where the authors argued that one of the critical, but frequently unaccounted reasons for pre-clinical research irreproducibility, was role of microbiome in shaping physiology and phenotype of laboratory animals. I am going to highlight some of the important messages from this article. Another important recommendation, the authors say, would be to conduct key experiments “in multipl...

5

My view on “An incentive-based approach for improving data reproducibility” | niaIDEAlist's Report

https://davidusharauli.wordpress.com/2016/05/01/my-view-on-an-incentive-based-approach-for-improving-data-reproducibility

My view on “An incentive-based approach for improving data reproducibility”. May 1, 2016. This week Science Translational Medicine published the commentary by Michael Rosenblatt, Chief Medical Officer at the big Pharma company Merck & Co., addressing the problem of research data reproducibility. The main starting point for this proposal is the fact that currently “industry expends and universities collect funding, even when the original data cannot be reproduced.”. “Compensation...By accepting such arran...

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tirumalaikamala.wordpress.com

Tirumalai Kamala | TK Talk

https://tirumalaikamala.wordpress.com/author/tirumalaikamala

Demystify science, Kant not cant. How do SSRIs affect the microbiome? Posted by Tirumalai Kamala. Asymp; Leave a comment. Major depressive disorder (MDD). Selective serotonin reuptake inhibitor (SSRI). 90% of serotonin goes to the gut. Could this be a possible mechanism why SSRIs cause weight gain in some people? 5-hydroxytryptamine, 5-HT) refers to where. It’s made. 90% of the body’s 5-HT is apparently made by the gastrointestinal Enterochromaffin cell. Selective serotonin reuptake inhibitor. Of three p...

tirumalaikamala.wordpress.com

Why is meldonium considered a performance enhancing drug? | TK Talk

https://tirumalaikamala.wordpress.com/2017/01/04/why-is-meldonium-considered-a-performance-enhancing-drug

Demystify science, Kant not cant. Why is meldonium considered a performance enhancing drug? Posted by Tirumalai Kamala. Asymp; Leave a comment. WADA (the World Anti-Doping Agency). The Latvian Institute of Organic Synthesis developed Meldonium. Mildronate; 3-(2,2,2-trimethylhydrazinium proprionate) in the late 1970s to promote growth in animals ( 1. According to Sjakste and Kalvinsh ( 3. As both potently inhibit beta-oxidation of free fatty acids, and thus strongly influence cardiac metabolism. States &#...

davidusharauli.blogspot.com

Carbon-derived environmental pollutants induce atopic dermatitis-associated skin itch via Artemin | NIHilist's Immunology

http://davidusharauli.blogspot.com/2016/11/carbon-derived-environmental-pollutants.html

How Immune System works. Saturday, November 26, 2016. Carbon-derived environmental pollutants induce atopic dermatitis-associated skin itch via Artemin. It has been recognized that various organic [ carbon-derived. Pollutants activate the transcription factor AhR ( aryl hydrocarbon receptor. AD), a chronic, itchy skin inflammation. New study in Nature Immunology. Showed that AhR signaling in response to organic pollutants initiates skin itch by producing neurotrophic factor, Artemin. Approximately 70% ef...

tirumalaikamala.wordpress.com

Is immunotherapy the closest thing we have to a cure for cancer? | TK Talk

https://tirumalaikamala.wordpress.com/2017/01/08/is-immunotherapy-the-closest-thing-we-have-to-a-cure-for-cancer

Demystify science, Kant not cant. Is immunotherapy the closest thing we have to a cure for cancer? Posted by Tirumalai Kamala. Asymp; Leave a comment. CAR-T (Chimeric antigen receptor). TILs (tumor infiltrating leukocytes). Refers to: http:/ www.popsci.com/why-are-scientists-shocked-by-results-this-cancer-treatment-trial. Yes, impressive results but no more impressive than the original CAR-T ( Chimeric antigen receptor. Results that Carl June. Got back in 2013 ( 1. Other important unanswered questions.

davidusharauli.blogspot.com

Lactobacillus reuteri extends lifespan of FOXP3-deficient scurfy mouse via microbiota–inosine–A2A receptor axis | NIHilist's Immunology

http://davidusharauli.blogspot.com/2016/12/lactobacillus-reuteri-extends-lifespan.html

How Immune System works. Tuesday, December 20, 2016. Lactobacillus reuteri extends lifespan of FOXP3-deficient scurfy mouse via microbiota–inosine–A2A receptor axis. Scurfy mice harbor natural mutation in FOXP3 gene that clinically resembles FOXP3 deficiency. In this regard, a new paper in Journal of Experimental Medicine. Is of great interest. It showed that a member of gut microflora, Lactobacillus reuteri. Morphologically, oral Lactobacillus reuteri. Effect on scurfy mice. In summary, this study revea...

tirumalaikamala.wordpress.com

How big of a healthcare problem is vision impairment? | TK Talk

https://tirumalaikamala.wordpress.com/2017/01/11/how-big-of-a-healthcare-problem-is-vision-impairment

Demystify science, Kant not cant. How big of a healthcare problem is vision impairment? Posted by Tirumalai Kamala. Asymp; Leave a comment. Refers to: https:/ www.sciencedaily.com/releases/2016/02/160217113308.htm. Myopia is becoming a bigger issue but situation’s nowhere as alarmist as these headlines suggest.Too bad, Science Daily sensationally highlighted these projected numbers without critically examining how. The article refers to a prevalence study ( 1. Done by the Brien Holden Vision Institute.

davidusharauli.blogspot.com

Protozoa-enabled non-genetic colitis after T cell transfer in immune-deficient mice | NIHilist's Immunology

http://davidusharauli.blogspot.com/2016/12/protozoa-enabled-non-genetic-colitis.html

How Immune System works. Tuesday, December 13, 2016. Protozoa-enabled non-genetic colitis after T cell transfer in immune-deficient mice. Adoptive transfer of naive T cells. Into T-cell deficient host mice has been used as a colitis (gut inflammation) model that led to discovery of FOXP3 T regulatory cells which when co-transferred with naive T cells prevented gut immunopathology. A new study in Journal of Experimental Medicine. Enabled dominant colitis that could not be prevented by FOXP3 T regs. In Rip...

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Para que possam partilhar um bocadinho da minha nova vida. Ora cá fica a foto final de curso ("hero shot" como eles chamam) do quase Piloto David Coito. Na sexta feira dia 30 de Junho irei finalmente receber as tão desejadas asas de Piloto Aviador, mas para já vai ser só a versão Americana (Silver Wings), vou ter que esperar até chegar a Portugal para ser uma questão de dias (ou meses) para ser brevetado com as asas Portuguesas. Posted by davidcoito at 6:15:00 PM. Cá fica uma foto do brinquedo novo!

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How Immune System works. Tuesday, December 20, 2016. Lactobacillus reuteri extends lifespan of FOXP3-deficient scurfy mouse via microbiota–inosine–A2A receptor axis. Scurfy mice harbor natural mutation in FOXP3 gene that clinically resembles FOXP3 deficiency. In this regard, a new paper in Journal of Experimental Medicine. Is of great interest. It showed that a member of gut microflora, Lactobacillus reuteri. Morphologically, oral Lactobacillus reuteri. Effect on scurfy mice. In summary, this study revea...

davidusharauli.wordpress.com

niaIDEAlist's Report

Microbiome and research reproducibility. June 11, 2016. This week journal Nature published a long overdue perspective where the authors argued that one of the critical, but frequently unaccounted reasons for pre-clinical research irreproducibility, was role of microbiome in shaping physiology and phenotype of laboratory animals. I am going to highlight some of the important messages from this article. Another important recommendation, the authors say, would be to conduct key experiments “in multipl...

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