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Blog - Latest News. October 22, 2014. Cynomolgus Monkey as Host for the Prediction of Drug Transporter Interactions. Written by Marton Jani, SOLVO Biotechnology. The following monkey drug transporter proteins have been cloned and characterized. As of mid 2014: OAT1, OAT3, OATP1B1, OATP1B3, OATP2B1, MRP1, MRP2, P-gp. 2-3 fold) between human and monkey when applying verapamil and quinidine as inhibitors, digoxin and cyclosporine A as probes. (Takeuchi et al 2006, Suzuyama et al 2007). Primary hepatocytes h...

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Blog - Latest News. October 22, 2014. Cynomolgus Monkey as Host for the Prediction of Drug Transporter Interactions. Written by Marton Jani, SOLVO Biotechnology. The following monkey drug transporter proteins have been cloned and characterized. As of mid 2014: OAT1, OAT3, OATP1B1, OATP1B3, OATP2B1, MRP1, MRP2, P-gp. 2-3 fold) between human and monkey when applying verapamil and quinidine as inhibitors, digoxin and cyclosporine A as probes. (Takeuchi et al 2006, Suzuyama et al 2007). Primary hepatocytes h...
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Drug Transporter Forum | | drugtransporterforum.org Reviews

https://drugtransporterforum.org

Blog - Latest News. October 22, 2014. Cynomolgus Monkey as Host for the Prediction of Drug Transporter Interactions. Written by Marton Jani, SOLVO Biotechnology. The following monkey drug transporter proteins have been cloned and characterized. As of mid 2014: OAT1, OAT3, OATP1B1, OATP1B3, OATP2B1, MRP1, MRP2, P-gp. 2-3 fold) between human and monkey when applying verapamil and quinidine as inhibitors, digoxin and cyclosporine A as probes. (Takeuchi et al 2006, Suzuyama et al 2007). Primary hepatocytes h...

INTERNAL PAGES

drugtransporterforum.org drugtransporterforum.org
1

Drug Transporter Forum | TAKE INTO CONSIDERATION CLINICALLY RELEVANT TRANSPORTER POLYMORPHISMS

http://www.drugtransporterforum.org/take-home-messages-form-the-itc-papers-part-6

Blog - Latest News. TAKE INTO CONSIDERATION CLINICALLY RELEVANT TRANSPORTER POLYMORPHISMS. August 31, 2013. TAKE INTO CONSIDERATION CLINICALLY RELEVANT TRANSPORTER POLYMORPHISMS. TAKE HOME MESSAGES FORM THE ITC PAPERS part 6. Giacomini, K.M., et al., International transporter consortium commentary on clinically important transporter polymorphisms. Pharmacol Ther, 2013. 94. 1THERE ARE A NUMBER OF ADDITIONAL TRANSPORTERS. CHOOSE YOUR METHODS WISELY. ARE WE LOST IN TRANSLATION…? Want to join the discussion?

2

Drug Transporter Forum | UWRAPT

http://www.drugtransporterforum.org/uwrapt

Blog - Latest News. September 13, 2013. Bhagwat Prasad, Ph.D. The University of Washington Research Affiliate program on Transporters. For more information about UWRAPT membership (including how to join UWRAPT), collaboration opportunities and UWRAPT publications/abstracts please visit http:/ sop.washington.edu/uwrapt. Interindividual Variability in Hepatic Oatps and P-Glycoprotein (ABCB1) Protein Expression: Quantification by LC-MS/MS and Influence of Genotype, Age and Sex. CHOOSE YOUR METHODS WISELY.

3

Drug Transporter Forum | EFFLUX TRANSPORTER MEDIATED DDIs AT THE BBB ARE UNLIKELY

http://www.drugtransporterforum.org/take-home-messages-from-the-itc-papers-part-7

Blog - Latest News. EFFLUX TRANSPORTER MEDIATED DDIs AT THE BBB ARE UNLIKELY. September 5, 2013. EFFLUX TRANSPORTER MEDIATED DDIs AT THE BBB ARE UNLIKELY. TAKE HOME MESSAGES FORM THE ITC WHITE PAPERS part 7. The authors demonstrate that only in cases of near complete inhibition (I/K. Of the transporters involved in efflux at the BBB is the fold increase in CNS exposure for a drug significant. The authors also review a number of in vitro. Models, in vivo. Clin Pharmacol Ther, 2013. 94. Feel free to contri...

4

Drug Transporter Forum | CHOOSE YOUR METHODS WISELY

http://www.drugtransporterforum.org/take-home-messages-from-the-itc-white-papers-part-3

Blog - Latest News. CHOOSE YOUR METHODS WISELY. August 16, 2013. CHOOSE YOUR METHODS WISELY. TAKE HOME MESSAGES FROM THE ITC PAPERS part 3. Although a variety of in vitro. Methods to study ABC and SLC transporters are available, Brouwer et al. focus on 5 methods, as these are currently the most widely used:. Uptake assays in transfected cell lines. Bidirectional transport assays in polarized (transfected) cell lines. Uptake assays in plated hepatocytes or hepatocytes in suspension. Possible to investigat...

5

Drug Transporter Forum | Cynomolgus Monkey as Host for the Prediction of Drug Transporter Interactions

http://www.drugtransporterforum.org/cynomolgus-monkey-as-host-for-the-prediction-of-drug-transporter-interactions

Blog - Latest News. Cynomolgus Monkey as Host for the Prediction of Drug Transporter Inter. August 1, 2014. Cynomolgus Monkey as Host for the Prediction of Drug Transporter Interactions. Written by Marton Jani, SOLVO Biotechnology. The cynomolgus monkey (Macaca fascicularis) is an important non-human primate species that is widely applied in preclinical studies during drug discovery and development. Both physiology and sequential homology are comparable to that of the two closest relative species (ch...

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Drug Transporter Forum |

Blog - Latest News. October 22, 2014. Cynomolgus Monkey as Host for the Prediction of Drug Transporter Interactions. Written by Marton Jani, SOLVO Biotechnology. The following monkey drug transporter proteins have been cloned and characterized. As of mid 2014: OAT1, OAT3, OATP1B1, OATP1B3, OATP2B1, MRP1, MRP2, P-gp. 2-3 fold) between human and monkey when applying verapamil and quinidine as inhibitors, digoxin and cyclosporine A as probes. (Takeuchi et al 2006, Suzuyama et al 2007). Primary hepatocytes h...

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