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IRX-2 & IRX-2 REGIMENS. IMMUNE SYSTEM IN HNSCC. HUMORAL VS CELLULAR IMMUNITY. TO THE INSPIRE STUDY SITE.

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IRX-2 & IRX-2 REGIMENS. IMMUNE SYSTEM IN HNSCC. HUMORAL VS CELLULAR IMMUNITY. TO THE INSPIRE STUDY SITE.
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Home - IRX Inspire HNSCC | hcp.inspirehnc.com Reviews

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IRX-2 & IRX-2 REGIMENS. IMMUNE SYSTEM IN HNSCC. HUMORAL VS CELLULAR IMMUNITY. TO THE INSPIRE STUDY SITE.

INTERNAL PAGES

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1

Immunity in HNSCC - IRX Inspire HNSCC

http://hcp.inspirehnc.com/immunity-in-hnscc

IRX-2 & IRX-2 REGIMENS. IMMUNE SYSTEM IN HNSCC. HUMORAL VS CELLULAR IMMUNITY. HUMORAL VS CELLULAR IMMUNITY. IN HEAD and NECK SQUAMOUS CELL CARCINOMA. Subjects with head and neck cancer are consistently immunocompromised. At the time of presentation. Hadden JW et al.

2

Administration - IRX Inspire HNSCC

http://hcp.inspirehnc.com/administration

IRX-2 & IRX-2 REGIMENS. IMMUNE SYSTEM IN HNSCC. HUMORAL VS CELLULAR IMMUNITY. ADMINISTRATION OF IRX-2 AS PART OF THE NEOADJUVANT REGIMEN. In head and neck squamous cell carcinoma, the IRX-2 biologic is injected into the mastoid region and drains into the lymphatic vessels, where physiologic quantities of IRX-2 restore the lymph node microenvironment and enable dendritic cells (DCs) to activate T cells against endogenous tumor peptides that have drained to the lymph node.

3

Cellular Immunity - IRX Inspire HNSCC

http://hcp.inspirehnc.com/cellular-immunity

IRX-2 & IRX-2 REGIMENS. IMMUNE SYSTEM IN HNSCC. HUMORAL VS CELLULAR IMMUNITY. HUMORAL VS CELLULAR IMMUNITY. In a healthy immune system, the cellular immune response works to clear foreign pathogens every day. Immature dendritic cells (DCs) ingest disease antigens, then migrate to lymph nodes where they mature. The mature DCs activate naïve T cells and create cytotoxic T cells. The cytotoxic T cells proliferate, enter the circulation, search out, and kill the antigenic target.

4

Humoral vs Cellular Immunity - IRX Inspire HNSCC

http://hcp.inspirehnc.com/humoral-v-cellular

IRX-2 & IRX-2 REGIMENS. IMMUNE SYSTEM IN HNSCC. HUMORAL VS CELLULAR IMMUNITY. HUMORAL VS CELLULAR IMMUNITY. The immune system can be broadly divided into a cellular and a humoral response. The cellular immune response relies on T cells, whereas the humoral immune response involves antibodies. Most cancer vaccines are directed at achieving a cellular immune response.

5

MOA - IRX Inspire HNSCC

http://hcp.inspirehnc.com/moa

IRX-2 & IRX-2 REGIMENS. IMMUNE SYSTEM IN HNSCC. HUMORAL VS CELLULAR IMMUNITY. THE NEED FOR MULTIPLE MECHANISMS OF ACTION IN CANCER IMMUNOTHERAPY. Given the numerous cellular defects present in cancer, IRX believes that any single receptor cannot restore all cellular immune responses. Therefore:. Must be enlisted for an effective cellular immune response. There may be a benefit to a biologic with multiple active components versus a single cytokine. IRX-2 MECHANISMS OF ACTION. IRX-2 MECHANISMS OF ACTION.

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Need for New Treatments - IRX Inspire HNSCC

http://patient.inspirehnc.com/need-for-new-treatments

For Health Care Professionals. NEED FOR NEW TREATMENTS. IRX-2, THE IMMUNE SYSTEM, AND CANCER. IRX-2, THE IMMUNE SYSTEM, AND CANCER. THE IMMUNE SYSTEM FIGHTS CANCER. IRX-2 MAY STRENGTHEN THE IMMUNE SYSTEM. HOW IRX-2 IS GIVEN. What is Oral Cancer? Need for New Treatments. NEW TREATMENTS FOR ORAL CANCER. Standard treatments help many people with oral cancer feel better and live longer. However, in many cases, they are not able to kill all the cancer or to prevent it from coming back.

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Treatments - IRX Inspire HNSCC

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For Health Care Professionals. NEED FOR NEW TREATMENTS. IRX-2, THE IMMUNE SYSTEM, AND CANCER. IRX-2, THE IMMUNE SYSTEM, AND CANCER. THE IMMUNE SYSTEM FIGHTS CANCER. IRX-2 MAY STRENGTHEN THE IMMUNE SYSTEM. HOW IRX-2 IS GIVEN. What is Oral Cancer? Need for New Treatments. Before starting treatment, your doctor will probably perform many tests. These tests will help your doctor understand your cancer. Your doctor will perform a careful examination of your mouth, throat, and the surrounding areas. Immunother...

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What is Oral Cancer? - IRX Inspire HNSCC

http://patient.inspirehnc.com/oral-cancer

For Health Care Professionals. NEED FOR NEW TREATMENTS. IRX-2, THE IMMUNE SYSTEM, AND CANCER. IRX-2, THE IMMUNE SYSTEM, AND CANCER. THE IMMUNE SYSTEM FIGHTS CANCER. IRX-2 MAY STRENGTHEN THE IMMUNE SYSTEM. HOW IRX-2 IS GIVEN. What is Oral Cancer? Need for New Treatments. Oral cancer is part of a group of cancers that affect the head and neck. Cancer is called oral cancer if it starts in:. The inside lining of the lips and cheeks. The front two-thirds of the tongue. The floor of the mouth below the tongue.

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IRX-2, THE IMMUNE SYSTEM, AND CANCER - IRX Inspire HNSCC

http://patient.inspirehnc.com/immune-system

For Health Care Professionals. NEED FOR NEW TREATMENTS. IRX-2, THE IMMUNE SYSTEM, AND CANCER. IRX-2, THE IMMUNE SYSTEM, AND CANCER. THE IMMUNE SYSTEM FIGHTS CANCER. IRX-2 MAY STRENGTHEN THE IMMUNE SYSTEM. HOW IRX-2 IS GIVEN. IRX-2, THE IMMUNE SYSTEM, AND CANCER. The Immune System Fights Cancer. IRX-2 May Strengthen the Immune System. How IRX-2 is Given. Messengers, which send messages between different types of cells. Fighters, which kill other cells. Regulators, which turn other cells on or off.

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Find Support - IRX Inspire HNSCC

http://patient.inspirehnc.com/support

For Health Care Professionals. NEED FOR NEW TREATMENTS. IRX-2, THE IMMUNE SYSTEM, AND CANCER. IRX-2, THE IMMUNE SYSTEM, AND CANCER. THE IMMUNE SYSTEM FIGHTS CANCER. IRX-2 MAY STRENGTHEN THE IMMUNE SYSTEM. HOW IRX-2 IS GIVEN. INFORMATION AND SUPPORT TO FIGHT ORAL CANCER. Here are some sources of information and support for people with oral cancer:. AMERICAN CANCER SOCIETY (US). Web: http:/ www.cancer.org/cancer/oralcavityandoropharyngealcancer/index. ORAL CANCER FOUNDATION (US). Web: www.spohnc.org.

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How to Participate - IRX Inspire HNSCC

http://patient.inspirehnc.com/how-to-participate

For Health Care Professionals. NEED FOR NEW TREATMENTS. IRX-2, THE IMMUNE SYSTEM, AND CANCER. IRX-2, THE IMMUNE SYSTEM, AND CANCER. THE IMMUNE SYSTEM FIGHTS CANCER. IRX-2 MAY STRENGTHEN THE IMMUNE SYSTEM. HOW IRX-2 IS GIVEN. IN THE INSPIRE STUDY. If you think you may want to participate in the INSPIRE study, you or your doctor can e-mail us at: INSPIRE@irxtherapeutics.com.

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Who is Eligible - IRX Inspire HNSCC

http://patient.inspirehnc.com/who-is-eligible

For Health Care Professionals. NEED FOR NEW TREATMENTS. IRX-2, THE IMMUNE SYSTEM, AND CANCER. IRX-2, THE IMMUNE SYSTEM, AND CANCER. THE IMMUNE SYSTEM FIGHTS CANCER. IRX-2 MAY STRENGTHEN THE IMMUNE SYSTEM. HOW IRX-2 IS GIVEN. FOR THE INSPIRE STUDY. You may be eligible if you:. Have oral cancer that has spread from the site where it started, but not throughout your body. Are scheduled to undergo surgery to remove the cancer. Are of reasonable general health and have lab test values within specific limits.

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How IRX-2 Works - IRX Inspire HNSCC

http://patient.inspirehnc.com/how-irx-2-works

For Health Care Professionals. NEED FOR NEW TREATMENTS. IRX-2, THE IMMUNE SYSTEM, AND CANCER. IRX-2, THE IMMUNE SYSTEM, AND CANCER. THE IMMUNE SYSTEM FIGHTS CANCER. IRX-2 MAY STRENGTHEN THE IMMUNE SYSTEM. HOW IRX-2 IS GIVEN. IRX-2, THE IMMUNE SYSTEM, AND CANCER. The Immune System Fights Cancer. IRX-2 May Strengthen the Immune System. How IRX-2 is Given. IRX-2 TURNS ON CANCER FIGHTERS.

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Home - IRX Inspire HNSCC

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For Health Care Professionals. NEED FOR NEW TREATMENTS. IRX-2, THE IMMUNE SYSTEM, AND CANCER. IRX-2, THE IMMUNE SYSTEM, AND CANCER. THE IMMUNE SYSTEM FIGHTS CANCER. IRX-2 MAY STRENGTHEN THE IMMUNE SYSTEM. HOW IRX-2 IS GIVEN. TO THE INSPIRE PATIENT SITE. IRX-2, THE IMMUNE SYSTEM, AND CANCER.

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How IRX-2 is Given - IRX Inspire HNSCC

http://patient.inspirehnc.com/how-irx-2-is-given

For Health Care Professionals. NEED FOR NEW TREATMENTS. IRX-2, THE IMMUNE SYSTEM, AND CANCER. IRX-2, THE IMMUNE SYSTEM, AND CANCER. THE IMMUNE SYSTEM FIGHTS CANCER. IRX-2 MAY STRENGTHEN THE IMMUNE SYSTEM. HOW IRX-2 IS GIVEN. IRX-2, THE IMMUNE SYSTEM, AND CANCER. The Immune System Fights Cancer. IRX-2 May Strengthen the Immune System. How IRX-2 is Given. Most of these other drugs are pills that you can take orally. One drug, however, is given just once by a tube into one of your veins. These drugs...After...

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Home - IRX Inspire HNSCC

IRX-2 & IRX-2 REGIMENS. IMMUNE SYSTEM IN HNSCC. HUMORAL VS CELLULAR IMMUNITY. TO THE INSPIRE STUDY SITE.

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