The Marasco Laboratory at Dana-Farber Cancer Institute constructs and validates various Human-Mouse chimeric models. These ‘humanized’ mouse models are excellent platforms to perform translational and preclinical research.
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Dana-Farber Cancer Institute
Dave Rothfarb
450 Br●●●●●●ne Ave
Bo●●on , MA, 02215
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View this contact
Dana-Farber Cancer Institute
Dave Rothfarb
450 Br●●●●●●ne Ave
Bo●●on , MA, 02215
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View this contact
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Humanized Mouse Program - Home | humouse.org Reviews
https://humouse.org
The Marasco Laboratory at Dana-Farber Cancer Institute constructs and validates various Human-Mouse chimeric models. These ‘humanized’ mouse models are excellent platforms to perform translational and preclinical research.
humouse.org
Humanized Mouse Program - Opportunities
http://www.humouse.org/index.php/opportunities
Applicants should have a strong interest in human translational research. Job openings are posted with Human Resources. Interested applicants should send their CV and cover letter to:. Wayne A. Marasco, M.D., Ph.D. Department of Cancer Immunology and AIDS. Boston, MA 02215. Please check for current opportunities at DFCI HR. Click on logos for links to our other sites. Site developed by DF/HCC Health Communication Core.
Humanized Mouse Program - Human infectious disease
http://www.humouse.org/index.php/relevant-literature/human-infectious-disease
Human immune system development. Generation of a humanized mouse model with both human immune system and liver cells to model hepatitis C virus infection and liver immunopathogenesis. Bility MT, Zhang L, Washburn ML, Curtis TA, Kovalev GI, Su L. Nat Protoc. 2012 Sep;7(9):1608-17. doi: 10.1038/nprot.2012.083. Epub 2012 Aug 9. PMID: 22899330. An Epstein-Barr virus (EBV) mutant with enhanced BZLF1 expression causes lymphomas with abortive lytic EBV infection in a humanized mouse model. Ma SD, Yu X, Mert...
Humanized Mouse Program - FAQ
http://www.humouse.org/index.php/mouse-model/faq
1 What is the extent of human immune-reconstitution in the different humanized mice models? 2 Do these mice develop characteristic lymphoid follicles in secondary lymphoid tissues? 3 Is the reconstructed human immune system functional in these mice? Click on logos for links to our other sites. Site developed by DF/HCC Health Communication Core.
Humanized Mouse Program - Hematopoiesis
http://www.humouse.org/index.php/relevant-literature/hematopoiesis
Human immune system development. Comparison of hematopoietic stem cells derived from fresh and cryopreserved whole cord blood in the generation of humanized mice. Scholbach J, Schulz A, Westphal F, Egger D, Wege AK, Patties I, Köberle M, Sack U, Lange F. PLoS One. 2012;7(10):e46772. doi: 10.1371/journal.pone.0046772. Epub 2012 Oct 11. PMID: 23071634. Antibody Repertoires in Humanized NOD-scid-IL2R? Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo. Rongvaux A, Willinge...
Humanized Mouse Program - Our Published Studies
http://www.humouse.org/index.php/mouse-model/marasco-studies
Studies in the Marasco Laboratory with these mouse models include:. Hong Chang, Subhabrata Biswas, Aimee St. Clair Tallarico, Phuong Thi Nguyen Sarkis, Shusheng Geng, Madhura M. Panditrao, Quan Zhu and Wayne A. Marasco. Human B-cell ontogeny in humanized NOD/SCID gcnull mice generates a diverse yet auto/poly- and HIV-1 reactive antibody repertoire. Genes and Immunity. 13, 399-410 (July/August 2012) doi:10.1038/gene.2012.16. PMID:22592523. Genes were amplified, cognate V. Abstract of talk by Hong Chang.
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Scientific Advisory Board | BioRestorative Therapies
http://www.biorestorative.com/content/scientific-advisory-board-0
Skip to main content. BioRestorative Therapies' combined Management Team, Board of Directors and Scientific Advisory Board members have extensive experience in the healthcare industry. Together we have expert experience in the stem cell science, medical-related services, life science services marketing, public company business management and financing, IP development and licensing, business acquisitions, and strategic partnering. Chief Medical Advisor for Spine Medicine. Gregory Lutz, M.D. Dr Cavagnaro’s...
Scientific focus and achievements
http://www.marascolab.com/index.php/about/scientific-focus-and-achievments
Core technologies and resources. Core technologies and resources. Scientific focus and achievements. Our National Foundation of Cancer Research (NFCR) Center for Therapeutic Antibody Engineering (CTAE). At Dana-Farber Cancer Institute is working in a broad range of discovery and translational research in cancer. We have the tools, know-how and expertise to advance our novel immunotherapy discoveries from bench to bedside. We have a major effort in constructing and improving humanized mice. Site developed...
Chief
http://www.marascolab.org/index.php/labpersonnel/chief
Wayne A. Marasco, M.D., Ph.D., Chief. Professor, Dept of Cancer Immunology and AIDS. Professor of Medicine, Department of Medicine. Associate Physician, Division of Infectious Diseases, Dept of Medicine. Brigham and Women's Hospital. Board of Distinguished Advisors, The Antibody Society. Email: This e-mail address is being protected from spambots. You need JavaScript enabled to view it. For use in regenerative medicine and adult stem cell research. Which can be delivered to cells by gene transfer techniq...
Scientific focus and achievements
http://www.marascolab.org/index.php/about/scientific-focus-and-achievments
Core technologies and resources. Core technologies and resources. Scientific focus and achievements. Our National Foundation of Cancer Research (NFCR) Center for Therapeutic Antibody Engineering (CTAE). At Dana-Farber Cancer Institute is working in a broad range of discovery and translational research in cancer. We have the tools, know-how and expertise to advance our novel immunotherapy discoveries from bench to bedside. We have a major effort in constructing and improving humanized mice. Site developed...
Scientific Advisory Board | BioRestorative Therapies
http://www.biorestorative.com/content/scientific-advisory-board
Skip to main content. BioRestorative Therapies' combined Management Team, Board of Directors and Scientific Advisory Board members have extensive experience in the healthcare industry. Together we have expert experience in the stem cell science, medical-related services, life science services marketing, public company business management and financing, IP development and licensing, business acquisitions, and strategic partnering. Chief Medical Advisor for Spine Medicine. Gregory Lutz, M.D. Dr Cavagnaro’s...
Announcements
http://www.marascolab.com/index.php/news/announcements
August 4, 2016. Access to primary tissue for humanized mouse studies. The Marasco Lab has recently been approved to collect matched PBMCs and tumor tissues from renal cell carcinoma patients that are undergoing therapeutic nephrectomy! This is the second cancer, in addition to ovarian cancer, that we will have access to primary tissue for our. Humanized mouse studies that will examine monoclonal antibodies and CAR T cells. Feb 3, 2012. Humanized Mouse Program open to research community. June 6, 2011.
Opportunities
http://www.marascolab.com/index.php/opportunities
Working in Dr. Marasco's laboratory provides exposure to the most recent developments in the field of antibody engineering, humanized mouse models. And adult stem cell biology. We are always looking for highly motivated post-doctoral fellows and graduate students to join our research team, particularly those individuals with high intellect who are also creative thinkers. Wayne A. Marasco, M.D., Ph.D. Department of Cancer Immunology and AIDS. Boston, MA 02215. Excellent communication and teamwork skills.
Announcements
http://www.marascolab.org/index.php/news/announcements
August 4, 2016. Access to primary tissue for humanized mouse studies. The Marasco Lab has recently been approved to collect matched PBMCs and tumor tissues from renal cell carcinoma patients that are undergoing therapeutic nephrectomy! This is the second cancer, in addition to ovarian cancer, that we will have access to primary tissue for our. Humanized mouse studies that will examine monoclonal antibodies and CAR T cells. Feb 3, 2012. Humanized Mouse Program open to research community. June 6, 2011.
Opportunities
http://www.marascolab.org/index.php/opportunities
Working in Dr. Marasco's laboratory provides exposure to the most recent developments in the field of antibody engineering, humanized mouse models. And adult stem cell biology. We are always looking for highly motivated post-doctoral fellows and graduate students to join our research team, particularly those individuals with high intellect who are also creative thinkers. Wayne A. Marasco, M.D., Ph.D. Department of Cancer Immunology and AIDS. Boston, MA 02215. Excellent communication and teamwork skills.
Chief
http://www.marascolab.com/index.php/labpersonnel/chief
Wayne A. Marasco, M.D., Ph.D., Chief. Professor, Dept of Cancer Immunology and AIDS. Professor of Medicine, Department of Medicine. Associate Physician, Division of Infectious Diseases, Dept of Medicine. Brigham and Women's Hospital. Board of Distinguished Advisors, The Antibody Society. Email: This e-mail address is being protected from spambots. You need JavaScript enabled to view it. For use in regenerative medicine and adult stem cell research. Which can be delivered to cells by gene transfer techniq...
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Humanized Mouse Program - Home
Oct 2012 - Opening of the Humanized Neonatal Mouse Center (HNMC). Human antibody gene repertoire analysis in hNSG mice. Affiliated Faculty of Harvard Stem Cell Institute. Feb 2012 - Humanized Mouse Program open to research community. Humanized Neonatal Mouse Center (HNMC). National Foundation for Cancer Research - Center for Therapeutic Antibody Engineering. Hu-mouse splenic follicle with human T (green) and B (red) cells. Humanized mice program for vaccine development and human antibody therapy.
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