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KINASE.COM

Protein Kinases, Kinomes and Evolution, at Kinase.Com

A resource on protein kinases, a key class of regulatory proteins. Includes genomic and evolutionary analyses (kinomes), classification, disease associationa and an extensive database of protein kinase genes.

http://www.kinase.com/

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Evolutionary Bioinformatics

Geradr Manning

10564 Cor●●●●●●●●●n Del Mar

San●●●ego , California, 92130

United States

1.65●●●●2663
ma●●●●●@manninglab.org

View this contact

Evolutionary Bioinformatics

Geradr Manning

10564 Cor●●●●●●●●●n Del Mar

San●●●ego , California, 92130

United States

1.65●●●●2663
ma●●●●●@manninglab.org

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Protein Kinases, Kinomes and Evolution, at Kinase.Com | kinase.com Reviews
<META>
DESCRIPTION
A resource on protein kinases, a key class of regulatory proteins. Includes genomic and evolutionary analyses (kinomes), classification, disease associationa and an extensive database of protein kinase genes.
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1 kinase
2 protein kinase
3 kinome
4 signal transduction
5 phosphorylate
6 phosphorylation
7 kinases
8 protein kinases
9 receptor
10 cytoplasmic
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Protein Kinases, Kinomes and Evolution, at Kinase.Com | kinase.com Reviews

https://kinase.com

A resource on protein kinases, a key class of regulatory proteins. Includes genomic and evolutionary analyses (kinomes), classification, disease associationa and an extensive database of protein kinase genes.

INTERNAL PAGES

kinase.com kinase.com
1

HyperTree hyperbolic phylogenetic tree viewer

http://www.kinase.com/tools/HyperTree.html

Is a Java phylogenetic tree viewer, with a hyperbolic ('fish-eye') view and editing abilities that help in managing very large trees. June 2011): Hypertree v1.2.2 adds basic support for phyloXML and better newick format integration and a few bug fixes. Oct 2008): Hypertree v1.2 provides improved printing, import of distance matrices and simple heat map drawing. Mar 2008): Hypertree V1.1 includes numerous bug fixes and additional functionality. Mar 2008): Bug with license file now corrected. Protein kinas...

2

BLAST Search

http://www.kinase.com/blast/blast.html

Choose program to use and database to search:. Enter sequence below in FASTA. Or load it from disk. The query sequence is filtered. For low complexity regions by default. Mask for lookup table only. Query Genetic Codes (blastx only). Mold Mitochondrial; . (4). Ciliate Nuclear; . (6). Alternative Yeast Nuclear (12). Database Genetic Codes (tblast[nx] only). Mold Mitochondrial; . (4). Ciliate Nuclear; . (6). Alternative Yeast Nuclear (12). Flat master-slave with identities. Last modified: Jan 11, 2002.

3

Protein Kinase Evolution

http://www.kinase.com/evolution

The eukaryotic protein kinase family is one of the largest gene families in all eukaryotes, counting for 2-4% of all genes. By whole-kinome comparisons, we can relate kinases across highly divergent organisms and track the birth, spread, expansion, and even death of kinases. The data underlying this graph is available in Excel. Evolution of protein kinase signaling from yeast to man. G Manning, GD Plowman, T Hunter, S Sudarsanam (2002). Trends in Biochemical Sciences. 10): 514-520. ( PDF.

4

C. elegans Protein Kinases

http://www.kinase.com/celegans

The nematode C. elegans. Provides a powerful system for the study of protein kinases, as the first sequenced multicellular genome, with a wealth of genetics and genomics tools and data. Its evolutionary position provides important information on the evolution of kinases in multicellular animals, and the sequencing of additional nematode genomes promises additional sequence-function discoveries. Our latest revision and analysis of the kinases of C. elegans. And a preliminary analysis of the C. briggsae.

5

KinBase

http://www.kinase.com/kinbase/index.html

The kinase database at Sugen/Salk. F5 F8 type C. You can search by gene name and/or by kinase classification. Select the species to search using the check boxes. The search is case-insensitive, and you can use * as a wildcard character (e.g. ERK* or *-1), multiple queries must be separated by space. You can also search by class: group (e.g. TK), family (e.g. MAPK) or subfamily (e.g. ERK). To download all sequences from any kinome see the Sequence download. To Kinase.com home.

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qmgsc.org qmgsc.org

Expression Genomics Laboratory

http://www.qmgsc.org/links.html

Institute for Molecular Bioscience, Uni of QLD, Australia. Http:/ phosphoreg.imb.uq.edu.au/. Http:/ variant.imb.uq.edu.au/. Http:/ www.cellsignal.com/reference/kinase/kinome.html. Http:/ alpha.kinasenet.org/pkr/Welcome.do. The Vertebrate Secretome and CTT-ome Database. Http:/ www.secretomes.umn.edu/. Http:/ locate.imb.uq.edu.au/. Http:/ www.cbs.dtu.dk/services/. Http:/ spring.imb.uq.edu.au/. Http:/ fantom3.gsc.riken.jp/. Http:/ www.informatics.jax.org/. Http:/ genome.ucsc.edu/. Kidney SCGAP data website.

life.ccs.miami.edu life.ccs.miami.edu

Acknowledgement

http://life.ccs.miami.edu/life/acknowledgement

The University of Miami LINCS Center. Is a member of the LINCS Consortium. Supported by the NIH Common Fund. We gratefully acknowledge the following contributions:. The LINCS Data Production Centers (U54) and Technology Centers (U01) for taking the time to work with us and provide the data and metadata. Harvard Medical School (HMS) LINCS Center (U54). LINCS assays indexed in LIFEwrx: Apoptosis assay. Cell cycle state assay. Cell growth inhibition assay. Broad Institute LINCS Center (U54). Dr Shamu and te...

crt.biomol.uci.edu crt.biomol.uci.edu

Cahalan Lab - Lab Links

http://crt.biomol.uci.edu/links/index.html

Cover Photos and Snapshots. Department of Physiology and Biophysics, UCI. Http:/ www.physiology.uci.edu/faculty/index.htm. School of Biological Sciences seminars and events calendar. Http:/ www.bio.uci.edu/events/index.cfm. Department of Physiology and Biophysics graduate student handbook: academic student policies, procedures, and guidelines. Http:/ www.physiology.uci.edu/training/Physiology%20Handbook%206 22 10.pdf. Ian Parker’s lab:. Http:/ parkerlab.bio.uci.edu/. UCI Institute for Immunology. Http:/ ...

grimmond.imb.uq.edu.au grimmond.imb.uq.edu.au

Expression Genomics Laboratory

http://grimmond.imb.uq.edu.au/links.html

Institute for Molecular Bioscience, Uni of QLD, Australia. Http:/ phosphoreg.imb.uq.edu.au/. Http:/ variant.imb.uq.edu.au/. Http:/ www.cellsignal.com/reference/kinase/kinome.html. Http:/ alpha.kinasenet.org/pkr/Welcome.do. The Vertebrate Secretome and CTT-ome Database. Http:/ www.secretomes.umn.edu/. Http:/ locate.imb.uq.edu.au/. Http:/ www.cbs.dtu.dk/services/. Http:/ spring.imb.uq.edu.au/. Http:/ fantom3.gsc.riken.jp/. Http:/ www.informatics.jax.org/. Http:/ genome.ucsc.edu/. Kidney SCGAP data website.

pkr.genomics.purdue.edu pkr.genomics.purdue.edu

Protein Kinase Resource

http://pkr.genomics.purdue.edu/pkr/static.do?p=/content/links.shtml

Suppliers of Phosphorylation-specific Antibodies. Other Suppliers for Phosphorylation Research. Other Protein Family Resources. Cell Signaling at Los Alamos National Lab. Alliance for Cellular Signaling. Signal Transduction Knowledge Environment. Protein Kinases at Cell Signaling Technology. Kinase Sequence Database - KSD. Scansite - Scans for protein sequence motifs and phosphorylation sites. DISPHOS: Disorder-Enhanced Phosphorylation Sites Predictor. Protein Kinase Substrate Prediction. 800) 645-6264 (...

phospho3d.org phospho3d.org

Phospho3D

http://www.phospho3d.org/links.py

Links Contacts and Download. Links to related resources. RCSB PDB - Protein Data Bank. Phosphorylation sites prediction tools.

igps.biocuckoo.org igps.biocuckoo.org

iGPS - Prediction of site-specific kinase-substrate relations from phosphoproteomic data

http://igps.biocuckoo.org/index.php

Last update: Feb. 10th, 2014. Catalyzed by protein kinases. PKs) is one of the most important and ubiquitous post-translational modifications. PTMs) of proteins. It temporally and spatially modifies approximately 30% of all cellular proteins, and plays a crucial role in regulating a variety of biological processes, such as signal transduction and the cell cycle ( Kobe,. Ptacek and Snyder, 2006. Ubersax and Ferrell, 2007. The human genome encodes 518 PK genes. Ptacek and Snyder, 2006. Tan and Linding, 2009.

ekpd.biocuckoo.org ekpd.biocuckoo.org

EKPD - Eukaryotic Protein Kinase & Protein Phosphatase Database

http://www.ekpd.biocuckoo.org/index.php

Last update: Jna. 28th, 2015. The reversible phosphorylation of proteins is one of the most important post-translational modifications, which is involved in varieties of cellular processes and plays a critical role in activation, inactivation and regulation of proteins. Two types of enzymes, known as protein kinase. Are responsible for this reversible reaction and almost constitute about 2 4% of the genes in a typical eukaryotic genome ( Moorhead. Transcription, cell cycle progression ( Moniz. As the cri...

ekpd.biocuckoo.org ekpd.biocuckoo.org

EKPD - Eukaryotic Protein Kinase & Protein Phosphatase Database

http://ekpd.biocuckoo.org/link.php

Last update: Jna. 28th, 2015. 8251; Computational Resources for Kinase and Phosphatase:. 1) Protein kinase databases. 2) Phosphorylation Sites Database. 3) Prediction of kinase-specific phosphorylation sites. 4) Prediction of non-specific or organism-specific phosphorylation sites. 5) Protein kinases associated with diseases. 1 Protein kinase databases. 2) Kinomer v. 1.0. Is a comprehensive collection of serine/threonine/tyrosine-specific kinases and their homologues identified in various completed genom...

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All information about Kinase Inhibitors. This study investigated the role of cancer/testis antigen DDX53 in regulating. Histological studies or snap-frozen for protein analysis by Western blot. Also tumor fragments were exposed to isolate CD133 and CD133? Cells using MACs system as explained previously. Remoteness of CD133 and CD133? Cells CD133 and CD133? Cells using MACs system as explained above. The ensuing cells were used as 1CM133 and 1CM133 (? 2CM133 and 2CM133 (? EZH2, a core member of the Poly...

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International Centre for Kinase Profiling | International Centre for Kinase Profiling

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Protein Kinases, Kinomes and Evolution, at Kinase.Com

Genomics, evolution and function of protein kinases. Explores the functions, evolution and diversity of protein kinases, the key controllers of cell behavior. We focus on the kinome, the full complement of protein kinases in any sequenced genome. This includes our extensive KinBase database, and papers and supporting material for our published kinase work from Sugen. And the Salk Institute. April 11, 2017. Our analysis of the phosphatome now published in Science Signaling. And our Phosphatase Wiki. Both ...

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