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My laboratory seeks to understand the biology of blood development, with a special interest in understanding malignant and pre-malignant blood diseases such as Myelodysplastic Sydrome (MDS) and Acute Myelogenous Leukemia (AML). Our eventual goal is to develop novel therapeutic strategies against MDS and AML, or to therapeutically affect the biology of normal blood-forming stem cells. Of particular interest to my lab is a disease called Myelodysplastic Syndrome or MDS. MDS is a complex and heterogeneo...

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My laboratory seeks to understand the biology of blood development, with a special interest in understanding malignant and pre-malignant blood diseases such as Myelodysplastic Sydrome (MDS) and Acute Myelogenous Leukemia (AML). Our eventual goal is to develop novel therapeutic strategies against MDS and AML, or to therapeutically affect the biology of normal blood-forming stem cells. Of particular interest to my lab is a disease called Myelodysplastic Syndrome or MDS. MDS is a complex and heterogeneo...
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Untitled Document | mukherjeelab.com Reviews

https://mukherjeelab.com

My laboratory seeks to understand the biology of blood development, with a special interest in understanding malignant and pre-malignant blood diseases such as Myelodysplastic Sydrome (MDS) and Acute Myelogenous Leukemia (AML). Our eventual goal is to develop novel therapeutic strategies against MDS and AML, or to therapeutically affect the biology of normal blood-forming stem cells. Of particular interest to my lab is a disease called Myelodysplastic Syndrome or MDS. MDS is a complex and heterogeneo...

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http://www.mukherjeelab.com/Publications.html

1 Raaijmakers, Marc. ,. Siyi Zhang, Tatsuya Kobayashi, Jesse A. Schoonmaker, Benjamin L. Ebert, Fatima Al-Shahrour, Robert P. Hasserjian , Edward O. Scadden, Zinmar Aung, Marc Matza, Matthias Merkenschlager, Charles Lin, Johanna M. Rommens and Scadden, D. Bone dysfunction enables myeloid dysplasia and secondary leukemia in mice. Article), 852-857 (8 April 2010). Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11851-6. 4 Vallet S, Mukherjee S* (. Proc Natl Acad Sci U S A. The Emperor of all Maladies.

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http://www.mukherjeelab.com/Techniques.html

The underlying technique our lab is built upon is a hematopoetic/mesenchymal stem cell coculture. In this system we are able to acurately recreate the bone marrow niche in-vitro, manipulate the microenvironment, and investigate the effects of such manipulations on the niche using fluorescence imaging, flow cytometry, in situ immunohistochemistry, and serial transplants.

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http://www.mukherjeelab.com/people.html

Siddhartha Mukherjee is a physician-scientist with a long-standing clinical and scientific interest in acute myeloid leukemia, hematopoiesis, drug development and cancer biology. Dr Mukherjee graduated from Stanford University, University of Oxford (as a Rhodes scholar) and Harvard Medical School. He is an Assistant Professor of Medicine at Columbia University.

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Untitled Document

My laboratory seeks to understand the biology of blood development, with a special interest in understanding malignant and pre-malignant blood diseases such as Myelodysplastic Sydrome (MDS) and Acute Myelogenous Leukemia (AML). Our eventual goal is to develop novel therapeutic strategies against MDS and AML, or to therapeutically affect the biology of normal blood-forming stem cells. Of particular interest to my lab is a disease called Myelodysplastic Syndrome or MDS. MDS is a complex and heterogeneo...

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